3',5'-cyclic AMP(1-) 3',5'-cyclic AMP anion; 3',5'-cyclic AMP; adenosine 3',5'-cyclic monophosphate anion; adenosine 3',5'-cyclic monophosphate; adenosine 3',5'-cyclic monophosphate(1-); adenosine 3',5'-phosphate An organophosphate oxoanion that is the conjugate base of 3',5'-cyclic AMP arising from deprotonation of the free phosphate OH group; major species at pH 7.3. C10H11N5O6P CHEBI:58165 InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 IVOMOUWHDPKRLL-KQYNXXCUSA-M https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:58165 cAMP cAMP-dependent protein kinase type II-alpha regulatory subunit Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase Cytoplasm, Cell membrane HGNC:9391 PRKAR2A PRKAR2 5576 ENSG00000114302 NM_001321982 P13861 https://www.uniprot.org/uniprotkb/P13861 PRKAR2A LABEL cAMP-dependent protein kinase type II-alpha regulatory subunit Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase Cytoplasm, Cell membrane HGNC:9391 PRKAR2A PRKAR2 5576 ENSG00000114302 NM_001321982 P13861 https://www.uniprot.org/uniprotkb/P13861 PRKAR2A cAMP-dependent protein kinase catalytic subunit alpha Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, histone H1.4 (H1-4), PSMC5/RPT6, PJA2, RYR2, RORA, SLC6A6, SOX9, UHRF1 and VASP. Cytoplasm, Cell membrane, Membrane, Nucleus, Mitochondrion, Cell projection, cilium, flagellum, Cytoplasmic vesicle, secretory vesicle, acrosome HGNC:9380 PRKACA PKACa 5566 ENSG00000072062 NM_002730 P17612 https://www.uniprot.org/uniprotkb/P17612 PRKACA LABEL cAMP-dependent protein kinase type II-alpha regulatory subunit Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase Cytoplasm, Cell membrane HGNC:9391 PRKAR2A PRKAR2 5576 ENSG00000114302 NM_001321982 P13861 https://www.uniprot.org/uniprotkb/P13861 PRKAR2A cAMP-dependent protein kinase catalytic subunit alpha Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, histone H1.4 (H1-4), PSMC5/RPT6, PJA2, RYR2, RORA, SLC6A6, SOX9, UHRF1 and VASP. Cytoplasm, Cell membrane, Membrane, Nucleus, Mitochondrion, Cell projection, cilium, flagellum, Cytoplasmic vesicle, secretory vesicle, acrosome HGNC:9380 PRKACA PKACa 5566 ENSG00000072062 NM_002730 P17612 https://www.uniprot.org/uniprotkb/P17612 PRKACA cAMP-dependent protein kinase catalytic subunit alpha Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, histone H1.4 (H1-4), PSMC5/RPT6, PJA2, RYR2, RORA, SLC6A6, SOX9, UHRF1 and VASP. Cytoplasm, Cell membrane, Membrane, Nucleus, Mitochondrion, Cell projection, cilium, flagellum, Cytoplasmic vesicle, secretory vesicle, acrosome HGNC:9380 PRKACA PKACa 5566 ENSG00000072062 NM_002730 P17612 https://www.uniprot.org/uniprotkb/P17612 PRKACA alpha-D-glucose 6-phosphate(2-) 6-O-phosphonato-alpha-D-glucopyranose; alpha-D-glucopyranose 6-phosphate; alpha-D-glucose 6-phosphate dianion; alpha-D-glucose 6-phosphate A D-glucopyranose 6-phosphate(2−) obtaned by deprotonation of the phosphate OH groups of α-D-glucose 6-phosphate; major species at pH 7.3. C6H11O9P CHEBI:58225 InChI=1S/C6H13O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-,6+/m1/s1 NBSCHQHZLSJFNQ-DVKNGEFBSA-L https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:58225 α-D-glucose-6P beta-D-fructofuranose 6-phosphate(2-) 6-O-phosphonato-beta-D-fructofuranose; beta-D-fructofuranose 6-phosphate dianion; beta-D-fructofuranose 6-phosphate; beta-D-fructose 6-phosphate An organophosphate oxoanion that is the dianion of β-D-fructofuranose 6-phosphate arising from deprotonation of the phosphate OH groups. C6H11O9P CHEBI:57634 InChI=1S/C6H13O9P/c7-2-6(10)5(9)4(8)3(15-6)1-14-16(11,12)13/h3-5,7-10H,1-2H2,(H2,11,12,13)/p-2/t3-,4-,5+,6-/m1/s1 BGWGXPAPYGQALX-ARQDHWQXSA-L https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:57634 β-D-fructose-6P Glucose-6-phosphate isomerase Autocrine motility factor; D-hexose-6-phosphate anomerase; Glucose-6-phosphate C2-epimerase; Neuroleukin; Phosphoglucose isomerase; Phosphohexose isomerase; Sperm antigen 36 Isomerase that catalyzes the conversion of alpha-D-glucose-6-phosphate to beta-D-fructose-6-phosphate, the second step in glycolysis, and the reverse reaction in gluconeogenesis, within the cytoplasm. Also shows C2-epimerase activity, interconverting D-glucose-6-phosphate (G6P) and D-mannose-6-phosphate (M6P). Cytoplasm, Secreted HGNC:4458 GPI AMF, NLK 2821 ENSG00000105220 NM_000175 P06744 https://www.uniprot.org/uniprotkb/P06744 GPI beta-D-fructofuranose 1,6-bisphosphate(4-) 1,6-di-O-phosphonato-beta-D-fructofuranose; beta-D-fructofuranose 1,6-bisphosphate; beta-D-fructose 1,6-bisphosphate A D-fructofuranose 1,6-bisphosphate(4−) that is the conjugate base of β-D-fructofuranose 1,6-bisphosphate. C6H10O12P2 CHEBI:32966 InChI=1S/C6H14O12P2/c7-4-3(1-16-19(10,11)12)18-6(9,5(4)8)2-17-20(13,14)15/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4-,5+,6-/m1/s1 RNBGYGVWRKECFJ-ARQDHWQXSA-J https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:32966 β-D-fructose-1,6P2 Fructose-1,6-bisphosphatase isozyme 2 D-fructose-1,6-bisphosphate 1-phosphohydrolase 2; Muscle FBPase Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate Cell junction, Cytoplasm, Nucleus, Cytoplasm, myofibril, sarcomere, Z line HGNC:3607 FBP2 8789 ENSG00000130957 NM_003837 O00757 https://www.uniprot.org/uniprotkb/O00757 FBP2 ATP-dependent 6-phosphofructokinase, muscle type 6-phosphofructokinase type A; Phosphofructo-1-kinase isozyme A; Phosphohexokinase Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis Cytoplasm HGNC:8877 PFKM PFK-1, PPP1R122, PFKX 5213 ENSG00000152556 NM_000289 P08237 https://www.uniprot.org/uniprotkb/P08237 PFKM beta-D-fructofuranose 2,6-bisphosphate(4-) 2,6-di-O-phosphonato-beta-D-fructofuranose; beta-D-fructofuranose 2,6-bisphosphate; beta-D-fructose 2,6-bisphosphate An organophosphate oxoanion that is the tetraanion of β-D-fructofuranose 2,6-bisphosphate. C6H10O12P2 CHEBI:58579 InChI=1S/C6H14O12P2/c7-2-6(18-20(13,14)15)5(9)4(8)3(17-6)1-16-19(10,11)12/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4-,5+,6+/m1/s1 YXWOAJXNVLXPMU-ZXXMMSQZSA-J https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:58579 β-D-fructose-2,6P2 ATP(4-) ATP; adenosine 5'-triphosphate(4-) A nucleoside triphosphate(4−) obtained by global deprotonation of the triphosphate OH groups of ATP; major species present at pH 7.3. C10H12N5O13P3 CHEBI:30616 InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-4/t4-,6-,7-,10-/m1/s1 ZKHQWZAMYRWXGA-KQYNXXCUSA-J https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:30616 ATP Adenylate cyclase type 5 ATP pyrophosphate-lyase 5; Adenylate cyclase type V; Adenylyl cyclase 5 Catalyzes the formation of the signaling molecule cAMP in response to G protein signaling. Mediates signaling downstream of ADRB1. Cell membrane, Cell projection, cilium HGNC:236 ADCY5 AC5 111 ENSG00000173175 NM_183357 O95622 https://www.uniprot.org/uniprotkb/O95622 ADCY5 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 6PF-2-K/Fru-2,6-P2ase heart-type isozyme Synthesis and degradation of fructose 2,6-bisphosphate HGNC:8873 PFKFB2 5208 ENSG00000123836 NM_001018053 O60825 https://www.uniprot.org/uniprotkb/O60825 PFKFB2 N:2 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 6PF-2-K/Fru-2,6-P2ase heart-type isozyme Synthesis and degradation of fructose 2,6-bisphosphate HGNC:8873 PFKFB2 5208 ENSG00000123836 NM_001018053 O60825 https://www.uniprot.org/uniprotkb/O60825 PFKFB2 N:2 Adenylate cyclase type 6 ATP pyrophosphate-lyase 6; Adenylate cyclase type VI; Adenylyl cyclase 6; Ca(2+)-inhibitable adenylyl cyclase Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells. Cell membrane, Cell projection, cilium, Cell projection, stereocilium HGNC:237 ADCY6 AC6 112 ENSG00000174233 NM_020983 O43306 https://www.uniprot.org/uniprotkb/O43306 ADCY6 diphosphate(3-) HP2O7(3-); diphosphate; hydrogen diphosphate A trivalent inorganic anion obtained by removal of all three protons from diphosphoric acid. HO7P2 CHEBI:33019 InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 XPPKVPWEQAFLFU-UHFFFAOYSA-K https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:33019 PPi cAMP cAMP N:2 N:2 N:2 cAMP cAMP N:2 N:2 P