1,2-diacyl-sn-glycero-3-phosphocholine 1,2-diacyl-sn-glycero-3-phosphocholine betaine; 1,2-diacyl-sn-glycero-3-phosphocholines; 3-sn-phosphatidylcholine; 3-sn-phosphatidylcholines; Diacyl PC; PC; Phosphatidylcholine; a 1,2-diacyl-sn-glycero-3-phosphocholine; lecithin The conjugate base of a 1,2-diacyl-sn-glycero-3-phosphocholine compound formed by deprotonation of the phosphate OH group. C10H18NO8PR2 CHEBI:57643 https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:57643 phosphatidylcholine Cytosolic phospholipase A2 Phospholipase A2 group IVA Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response. Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production. Cytoplasm, Golgi apparatus membrane, Nucleus envelope HGNC:9035 PLA2G4A cPLA2-alpha, PLA2G4 5321 ENSG00000116711 NM_024420 P47712 cPLA2α, main eicosanoid-producing isoform https://www.uniprot.org/uniprotkb/P47712 cPLA2 arachidonate (20:4n6); (5Z,8Z,11Z,14Z)-eicosatetraenoate; (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate; 5Z,8Z,11Z,14Z-eicosatetraenoate A long-chain fatty acid anion resulting from the removal of a proton from the carboxy group of arachidonic acid. C20H31O2 CHEBI:32395 InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- YZXBAPSDXZZRGB-DOFZRALJSA-M https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:32395 arachidonate prostaglandin G2(1-) (5Z)-7-{(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroperoxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl}hept-5-enoate; (5Z,9S,11R,13E,15S)-15-hydroperoxy-9,11-epidioxyprosta-5,13-dien-1-oate; prostaglandin G2 A prostaglandin carboxylic acid anion that is the conjugate base of prostaglandin G2, obtained by deprotonation of the carboxy group; major species at pH 7.3. C20H31O6 CHEBI:82629 InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 SGUKUZOVHSFKPH-YNNPMVKQSA-M https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:82629 PGG2 PTGS1; PTGS2 [{"symbol": "PTGS1", "props": [["Full name", "Prostaglandin G/H synthase 1"], ["Alternative names", "Cyclooxygenase-1; Prostaglandin H2 synthase 1; Prostaglandin-endoperoxide synthase 1"], ["Function", "Dual cyclooxygenase and peroxidase that plays an important role in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates AA to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide prostaglandin H2 (PGH2), the precursor of all 2-series prostaglandins and thromboxanes."], ["Location", "Microsome membrane, Endoplasmic reticulum membrane"], ["HGNC", "HGNC:9604"], ["HGNC symbol", "PTGS1"], ["HGNC aliases", "COX1, PGHS-1, PTGHS"], ["Entrez", "5742"], ["Ensembl", "ENSG00000095303"], ["RefSeq", "NM_000962"], ["UniProt", "P23219"], ["Note", "Constitutive cyclooxygenase"]]}, {"symbol": "PTGS2", "props": [["Full name", "Prostaglandin G/H synthase 2"], ["Alternative names", "Cyclooxygenase-2; PHS II; Prostaglandin H2 synthase 2; Prostaglandin-endoperoxide synthase 2"], ["Function", "Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates AA to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide prostaglandin H2 (PGH2), the precursor of all 2-series prostaglandins and thromboxanes."], ["Location", "Microsome membrane, Endoplasmic reticulum membrane, Nucleus inner membrane, Nucleus outer membrane"], ["HGNC", "HGNC:9605"], ["HGNC symbol", "PTGS2"], ["HGNC aliases", "COX2"], ["Entrez", "5743"], ["Ensembl", "ENSG00000073756"], ["RefSeq", "NM_000963"], ["UniProt", "P35354"], ["Note", "Inducible cyclooxygenase"]]}] COX-1/2 Cytosolic phospholipase A2 Phospholipase A2 group IVA Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response. Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production. Cytoplasm, Golgi apparatus membrane, Nucleus envelope HGNC:9035 PLA2G4A cPLA2-alpha, PLA2G4 5321 ENSG00000116711 NM_024420 P47712 cPLA2α, main eicosanoid-producing isoform https://www.uniprot.org/uniprotkb/P47712 cPLA2 MAPK3; MAPK1 [{"symbol": "MAPK3", "props": [["Full name", "Mitogen-activated protein kinase 3"], ["Alternative names", "ERT2; Extracellular signal-regulated kinase 1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; Microtubule-associated protein 2 kinase; p44-ERK1"], ["Function", "Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade."], ["Location", "Cytoplasm, Nucleus, Membrane, caveola, Cell junction, focal adhesion"], ["HGNC", "HGNC:6877"], ["HGNC symbol", "MAPK3"], ["HGNC aliases", "ERK1, p44mapk, p44erk1, ERK-1, PRKM3"], ["Entrez", "5595"], ["Ensembl", "ENSG00000102882"], ["RefSeq", "NM_001040056"], ["UniProt", "P27361"], ["Note", "Phosphorylates cPLA2α"]]}, {"symbol": "MAPK1", "props": [["Full name", "Mitogen-activated protein kinase 1"], ["Alternative names", "ERT1; Extracellular signal-regulated kinase 2; MAP kinase isoform p42; Mitogen-activated protein kinase 2"], ["Function", "Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade."], ["Location", "Cytoplasm, cytoskeleton, spindle, Nucleus, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm, Membrane, caveola, Cell junction, focal adhesion"], ["HGNC", "HGNC:6871"], ["HGNC symbol", "MAPK1"], ["HGNC aliases", "ERK, ERK2, p41mapk, MAPK2, PRKM2, PRKM1"], ["Entrez", "5594"], ["Ensembl", "ENSG00000100030"], ["RefSeq", "NM_002745"], ["UniProt", "P28482"], ["Note", "Phosphorylates cPLA2α"]]}] ERK1/2 MAP2K1; MAP2K2 [{"symbol": "MAP2K1", "props": [["Full name", "Dual specificity mitogen-activated protein kinase kinase 1"], ["Alternative names", "ERK activator kinase 1; MAPK/ERK kinase 1"], ["Function", "Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation."], ["Location", "Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body, Cytoplasm, Nucleus, Membrane"], ["HGNC", "HGNC:6840"], ["HGNC symbol", "MAP2K1"], ["HGNC aliases", "MEK1, MAPKK1, MKK1, PRKMK1"], ["Entrez", "5604"], ["Ensembl", "ENSG00000169032"], ["RefSeq", "NM_001411065"], ["UniProt", "Q02750"], ["Note", "Activates ERK1/2"]]}, {"symbol": "MAP2K2", "props": [["Full name", "Dual specificity mitogen-activated protein kinase kinase 2"], ["Alternative names", "ERK activator kinase 2; MAPK/ERK kinase 2"], ["Function", "Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases."], ["Location", "Cytoplasm, Membrane"], ["HGNC", "HGNC:6842"], ["HGNC symbol", "MAP2K2"], ["HGNC aliases", "MEK2, MKK2, PRKMK2"], ["Entrez", "5605"], ["Ensembl", "ENSG00000126934"], ["RefSeq", "NM_030662"], ["UniProt", "P36507"], ["Note", "Activates ERK1/2"]]}] MEK1/2 MAP2K1; MAP2K2 [{"symbol": "MAP2K1", "props": [["Full name", "Dual specificity mitogen-activated protein kinase kinase 1"], ["Alternative names", "ERK activator kinase 1; MAPK/ERK kinase 1"], ["Function", "Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation."], ["Location", "Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body, Cytoplasm, Nucleus, Membrane"], ["HGNC", "HGNC:6840"], ["HGNC symbol", "MAP2K1"], ["HGNC aliases", "MEK1, MAPKK1, MKK1, PRKMK1"], ["Entrez", "5604"], ["Ensembl", "ENSG00000169032"], ["RefSeq", "NM_001411065"], ["UniProt", "Q02750"], ["Note", "Activates ERK1/2"]]}, {"symbol": "MAP2K2", "props": [["Full name", "Dual specificity mitogen-activated protein kinase kinase 2"], ["Alternative names", "ERK activator kinase 2; MAPK/ERK kinase 2"], ["Function", "Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases."], ["Location", "Cytoplasm, Membrane"], ["HGNC", "HGNC:6842"], ["HGNC symbol", "MAP2K2"], ["HGNC aliases", "MEK2, MKK2, PRKMK2"], ["Entrez", "5605"], ["Ensembl", "ENSG00000126934"], ["RefSeq", "NM_030662"], ["UniProt", "P36507"], ["Note", "Activates ERK1/2"]]}] MEK1/2 MAPK3; MAPK1 [{"symbol": "MAPK3", "props": [["Full name", "Mitogen-activated protein kinase 3"], ["Alternative names", "ERT2; Extracellular signal-regulated kinase 1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; Microtubule-associated protein 2 kinase; p44-ERK1"], ["Function", "Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade."], ["Location", "Cytoplasm, Nucleus, Membrane, caveola, Cell junction, focal adhesion"], ["HGNC", "HGNC:6877"], ["HGNC symbol", "MAPK3"], ["HGNC aliases", "ERK1, p44mapk, p44erk1, ERK-1, PRKM3"], ["Entrez", "5595"], ["Ensembl", "ENSG00000102882"], ["RefSeq", "NM_001040056"], ["UniProt", "P27361"], ["Note", "Phosphorylates cPLA2α"]]}, {"symbol": "MAPK1", "props": [["Full name", "Mitogen-activated protein kinase 1"], ["Alternative names", "ERT1; Extracellular signal-regulated kinase 2; MAP kinase isoform p42; Mitogen-activated protein kinase 2"], ["Function", "Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade."], ["Location", "Cytoplasm, cytoskeleton, spindle, Nucleus, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm, Membrane, caveola, Cell junction, focal adhesion"], ["HGNC", "HGNC:6871"], ["HGNC symbol", "MAPK1"], ["HGNC aliases", "ERK, ERK2, p41mapk, MAPK2, PRKM2, PRKM1"], ["Entrez", "5594"], ["Ensembl", "ENSG00000100030"], ["RefSeq", "NM_002745"], ["UniProt", "P28482"], ["Note", "Phosphorylates cPLA2α"]]}] ERK1/2 RAF proto-oncogene serine/threonine-protein kinase Proto-oncogene c-RAF; Raf-1 Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). Cytoplasm, Cell membrane, Mitochondrion, Nucleus HGNC:9829 RAF1 Raf-1, c-Raf, CRAF 5894 ENSG00000132155 NM_002880 P04049 Activates MEK1/2 https://www.uniprot.org/uniprotkb/P04049 RAF1 RAF proto-oncogene serine/threonine-protein kinase Proto-oncogene c-RAF; Raf-1 Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). Cytoplasm, Cell membrane, Mitochondrion, Nucleus HGNC:9829 RAF1 Raf-1, c-Raf, CRAF 5894 ENSG00000132155 NM_002880 P04049 Activates MEK1/2 https://www.uniprot.org/uniprotkb/P04049 RAF1 P P P P P P P