LABEL Sec23 Sec24 Endoplasmic Reticulum LABEL Sterol INSIG1/2 LABEL SCAP INSIG1/2 Sterol SREBP2 LABEL SCAP SREBP2 LABEL SCAP Sec23 Sec24 Sar1 SREBP2 Sar1 LABEL Sec23 Sec24 Sar1 COPII-coated vesicle LABEL LABEL SCAP Sec23 Sec24 Sar1 SREBP2 Golgi LABEL SREBP2 SREBP2 S1P S2P LABEL SCAP SREBP2 SCAP Nucleus LABEL SREBP2 Transcription of target genes Importin-β Cholesterol biosynthesis precursor processed form mature form mature form