LABEL
Sec23
Sec24
Endoplasmic Reticulum
LABEL
Sterol
INSIG1/2
LABEL
SCAP
INSIG1/2
Sterol
SREBP2
LABEL
SCAP
SREBP2
LABEL
SCAP
Sec23
Sec24
Sar1
SREBP2
Sar1
LABEL
Sec23
Sec24
Sar1
COPII-coated vesicle
LABEL
LABEL
SCAP
Sec23
Sec24
Sar1
SREBP2
Golgi
LABEL
SREBP2
SREBP2
S1P
S2P
LABEL
SCAP
SREBP2
SCAP
Nucleus
LABEL
SREBP2
Transcription
of target genes
Importin-β
Cholesterol
biosynthesis
precursor
processed form
mature form
mature form