CYTOSOL CYTOSOL IRF1 fumarate aspartate citrulline O2 arginine NO iNOS IRF1 arginino-succcinate STAT1α STAT1α STAT1α iNOS CaM 1.14.13.39 CaM iNOS ASL N:4 ASS NUCLEUS NUCLEUS STAT1α IRF1 IRF1 iNOS iNOS IRF1 PLASMA MEMBRANE PLASMA MEMBRANE JAK1 JAK2 IFNγR2 IFNγR1 IFNγ IFNγR2 JAK1 JAK2 IFNγR1 IFNγ IFNγR1 IFNγR2 JAK1 JAK2 EXTRACELLULAR SPACE EXTRACELLULAR SPACE IFNγ arginine NO AND AND 2 2 2 ct:mRNA ct:mRNA P@Y701 P@S727 @Y701 @S727 N:2 N:2 N:2 N:2 ct:gene ct:mRNA ct:mRNA ct:gene N:2 N:2 @Y457 N:2 N:2 N:2 @Y457 N:2 N:2 P@Y457 N:2 N:2