1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-) 2,3-bis(alkanoyloxy)propyl (1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonatooxy)cyclohexyl phosphate; a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) The pentaanion of a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. C11H14O19P3R2 CHEBI:58456 Phosphatidylinositol 4,5-bisphosphate horizontal https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:58456 PI(4,5)P2 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-) 2,3-bis(alkanoyloxy)propyl (1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonatooxy)cyclohexyl phosphate; a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) The heptaanion of a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate; major species at pH 7.3. C11H13O22P4R2 CHEBI:57836 Phosphatidylinositol 3,4,5-trisphosphate horizontal https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:57836 PI(3,4,5)P3 INPP5D; INPPL1 [{"symbol": "INPP5D", "props": [["Full name", "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1"], ["Alternative names", "Inositol polyphosphate-5-phosphatase D; Inositol polyphosphate-5-phosphatase of 145 kDa; Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; SH2 domain-containing inositol 5'-phosphatase 1; p150Ship"], ["Function", "Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Also, is able to hydrolyze the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3), 1D-myo-inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate."], ["Location", "Cytoplasm, Cell membrane, Membrane raft, Cytoplasm, cytoskeleton, Membrane"], ["HGNC", "HGNC:6079"], ["HGNC symbol", "INPP5D"], ["HGNC aliases", "SHIP, hp51CN, SHIP1"], ["Entrez", "3635"], ["Ensembl", "ENSG00000168918"], ["RefSeq", "NM_001017915"], ["UniProt", "Q92835"], ["Note", "PI(3,4,5)P3 5-phosphatase, haematopoietic cells"]]}, {"symbol": "INPPL1", "props": [["Full name", "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2"], ["Alternative names", "Inositol polyphosphate phosphatase-like protein 1; Protein 51C; SH2 domain-containing inositol 5'-phosphatase 2"], ["Function", "Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Required for correct mitotic spindle orientation and therefore progression of mitosis."], ["Location", "Cytoplasm, cytosol, Cytoplasm, cytoskeleton, Membrane, Cell projection, filopodium, Cell projection, lamellipodium, Basal cell membrane, Nucleus, Nucleus speckle, Cytoplasm, cytoskeleton, spindle pole"], ["HGNC", "HGNC:6080"], ["HGNC symbol", "INPPL1"], ["HGNC aliases", "SHIP2"], ["Entrez", "3636"], ["Ensembl", "ENSG00000165458"], ["RefSeq", "NM_001567"], ["UniProt", "O15357"], ["Note", "PI(3,4,5)P3 5-phosphatase, ubiquitous"]]}] horizontal SHIP1/2 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-) 2,3-bis(alkanoxy)propyl (1S,2R,3S,4S,5R,6R)-2,3,4,6-tetrahydroxy-5-(phosphonatooxy)cyclohexyl phosphate; a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) The trianion of a 1-phosphatidyl-1D-myo-inositol 3-phosphate; major species at pH 7.3. C11H15O16P2R2 CHEBI:58088 horizontal https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:58088 PI3P 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-) (2R)-2,3-bis(alkanoyloxy)propyl (1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate; 1-(3-sn-phosphatidyl)-1D-myo-inositol 4-phosphate; 1-phosphatidyl-1D-myo-inositol-4-phosphate trianion; 1-phosphatidyl-1D-myo-inositol-4-phosphate; a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate); phosphatidylinositol-4-phosphate trianion; phosphatidylinositol-4-phosphate; phosphatidylinositol-4-phosphate(3-) An organophosphate oxoanion arising from deprotonation of the phosphate OH groups of 1-phosphatidyl-1D-myo-inositol-4-phosphate; major species at pH 7.3. C11H15O16P2R2 CHEBI:58178 horizontal https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:58178 PI4P horizontal horizontal 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-) 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate pentaanion; 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate; a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) An organophosphate oxoanion obtained via global deprotonation of the phosphate OH groups of 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate. C11H14O19P3R2 CHEBI:57658 horizontal https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:57658 PI(3,4)P2 horizontal horizontal SYNJ1; SYNJ2 [{"symbol": "SYNJ1", "props": [["Full name", "Polyphosphatidylinositol phosphatase SYNJ1"], ["Alternative names", "Synaptojanin-1"], ["Function", "Phosphatase that hydrolyzes phosphate groups from the inositol ring of phosphoinositides and inositol phosphates, in a domain-specific manner. The 5-PPase domain catalyzes removal of the 5-phosphate from substrates such as phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol-1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4)."], ["Location", "Cytoplasm, perinuclear region, Presynapse, Membrane"], ["HGNC", "HGNC:11503"], ["HGNC symbol", "SYNJ1"], ["HGNC aliases", "INPP5G, PARK20"], ["Entrez", "8867"], ["Ensembl", "ENSG00000159082"], ["RefSeq", "NM_003895"], ["UniProt", "O43426"], ["Note", "Phosphoinositide phosphatase, neurons"]]}, {"symbol": "SYNJ2", "props": [["Full name", "Polyphosphatidylinositol phosphatase SYNJ2"], ["Alternative names", "Synaptojanin-2"], ["Function", "Phosphatase that hydrolyzes phosphate groups from the inositol ring of phosphoinositides and inositol phosphates, in a domain-specific manner. The 5-PPase domain catalyzes removal of the 5-phosphate from substrates such as phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol-1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4)."], ["Location", "Cytoplasm, Cell membrane, Cell projection, ruffle membrane, Presynapse, Cytoplasm, cytoskeleton"], ["HGNC", "HGNC:11504"], ["HGNC symbol", "SYNJ2"], ["HGNC aliases", "INPP5H"], ["Entrez", "8871"], ["Ensembl", "ENSG00000078269"], ["RefSeq", "NM_003898"], ["UniProt", "O15056"], ["Note", "Phosphoinositide phosphatase"]]}] horizontal SYNJ1/2 Type II inositol 1,4,5-trisphosphate 5-phosphatase 75 kDa inositol polyphosphate-5-phosphatase; Phosphoinositide 5-phosphatase Regulates phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) cellular levels by cleaving the phosphate at the 5-position producing PtdIns(4)P. Also hydrolyzes the 5-position phosphate from inositol 1,4,5-trisphosphate (Ins(1,4,5)P3), thereby modulating cellular signaling events Cytoplasm, cytosol, Endoplasmic reticulum-Golgi intermediate compartment, Early endosome membrane, Membrane, Cytoplasmic vesicle, phagosome membrane, Golgi apparatus HGNC:6077 INPP5B 3633 ENSG00000204084 NM_005540 P32019 horizontal https://www.uniprot.org/uniprotkb/P32019 INPP5B Phosphatidylinositide 4-phosphatase SAC2 Inositol polyphosphate 5-phosphatase F; Sac domain-containing inositol phosphatase 2; Sac domain-containing phosphoinositide 4-phosphatase 2 Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PtdIns(4)P). May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to PtdIns, for a sequential dephosphorylation of (PtdIns(4,5)P2) at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling. Membrane, clathrin-coated pit, Early endosome, Recycling endosome HGNC:17054 INPP5F SAC2, KIAA0966, hSac2 22876 ENSG00000198825 NM_014937 Q9Y2H2 Phosphoinositide phosphatase horizontal https://www.uniprot.org/uniprotkb/Q9Y2H2 INPP5F horizontal OR Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Inositol polyphosphate 3-phosphatase; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3. Cytoplasm, Nucleus, Nucleus, PML body, Cell projection, dendritic spine, Postsynaptic density, Secreted HGNC:9588 PTEN MMAC1, TEP1, PTEN1, BZS, MHAM 5728 ENSG00000171862 NM_000314 P60484 PI(3,4,5)P3 3-phosphatase horizontal https://www.uniprot.org/uniprotkb/P60484 PTEN INPP4A; INPP4B [{"symbol": "INPP4A", "props": [["Full name", "Inositol polyphosphate-4-phosphatase type I A"], ["Alternative names", "Inositol polyphosphate 4-phosphatase type I; Type I inositol 3,4-bisphosphate 4-phosphatase"], ["Function", "Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). Also catalyzes inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate."], ["Location", "Early endosome membrane, Recycling endosome membrane, Cell membrane, Nucleus, Cytoplasm, Postsynaptic density"], ["HGNC", "HGNC:6074"], ["HGNC symbol", "INPP4A"], ["HGNC aliases", "INPP4"], ["Entrez", "3631"], ["Ensembl", "ENSG00000040933"], ["RefSeq", "NM_001566"], ["UniProt", "Q96PE3"], ["Note", "PI(3,4)P2 4-phosphatase"]]}, {"symbol": "INPP4B", "props": [["Full name", "Inositol polyphosphate 4-phosphatase type II"], ["Alternative names", "Type II inositol 3,4-bisphosphate 4-phosphatase"], ["Function", "Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate. Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles."], ["HGNC", "HGNC:6075"], ["HGNC symbol", "INPP4B"], ["Entrez", "8821"], ["Ensembl", "ENSG00000109452"], ["RefSeq", "NM_003866"], ["UniProt", "O15327"], ["Note", "PI(3,4)P2 4-phosphatase"]]}] horizontal INPP4A/B PIK3CA; PIK3R1; PIK3R2; PIK3R3 [{"symbol": "PIK3CA", "props": [["Full name", "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform"], ["Alternative names", "Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; Phosphoinositide 3-kinase alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; Serine/threonine protein kinase PIK3CA"], ["Function", "Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3)."], ["HGNC", "HGNC:8975"], ["HGNC symbol", "PIK3CA"], ["HGNC aliases", "PI3K"], ["Entrez", "5290"], ["Ensembl", "ENSG00000121879"], ["RefSeq", "NM_006218"], ["UniProt", "P42336"], ["Note", "p110α catalytic subunit"]]}, {"symbol": "PIK3R1", "props": [["Full name", "Phosphatidylinositol 3-kinase regulatory subunit alpha"], ["Alternative names", "Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha"], ["Function", "Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues."], ["Location", "Cytoplasm"], ["HGNC", "HGNC:8979"], ["HGNC symbol", "PIK3R1"], ["HGNC aliases", "GRB1, p85-ALPHA, p85, p85alpha"], ["Entrez", "5295"], ["Ensembl", "ENSG00000145675"], ["RefSeq", "NM_181504"], ["UniProt", "P27986"], ["Note", "p85α regulatory, most abundant"]]}, {"symbol": "PIK3R2", "props": [["Full name", "Phosphatidylinositol 3-kinase regulatory subunit beta"], ["Alternative names", "Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta"], ["Function", "Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology."], ["HGNC", "HGNC:8980"], ["HGNC symbol", "PIK3R2"], ["HGNC aliases", "P85B, p85, p85beta, p85-BETA"], ["Entrez", "5296"], ["Ensembl", "ENSG00000105647"], ["RefSeq", "NM_005027"], ["UniProt", "O00459"], ["Note", "p85β regulatory, broad expression"]]}, {"symbol": "PIK3R3", "props": [["Full name", "Phosphatidylinositol 3-kinase regulatory subunit gamma"], ["Alternative names", "Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; p55PIK"], ["Function", "Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1"], ["HGNC", "HGNC:8981"], ["HGNC symbol", "PIK3R3"], ["HGNC aliases", "p55"], ["Entrez", "8503"], ["Ensembl", "ENSG00000117461"], ["RefSeq", "NM_003629"], ["UniProt", "Q92569"], ["Note", "p55γ regulatory, brain and testis"]]}] horizontal PI3Kα PIK3CA; PIK3R1; PIK3R2; PIK3R3 [{"symbol": "PIK3CA", "props": [["Full name", "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform"], ["Alternative names", "Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; Phosphoinositide 3-kinase alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; Serine/threonine protein kinase PIK3CA"], ["Function", "Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3)."], ["HGNC", "HGNC:8975"], ["HGNC symbol", "PIK3CA"], ["HGNC aliases", "PI3K"], ["Entrez", "5290"], ["Ensembl", "ENSG00000121879"], ["RefSeq", "NM_006218"], ["UniProt", "P42336"], ["Note", "p110α catalytic subunit"]]}, {"symbol": "PIK3R1", "props": [["Full name", "Phosphatidylinositol 3-kinase regulatory subunit alpha"], ["Alternative names", "Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha"], ["Function", "Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues."], ["Location", "Cytoplasm"], ["HGNC", "HGNC:8979"], ["HGNC symbol", "PIK3R1"], ["HGNC aliases", "GRB1, p85-ALPHA, p85, p85alpha"], ["Entrez", "5295"], ["Ensembl", "ENSG00000145675"], ["RefSeq", "NM_181504"], ["UniProt", "P27986"], ["Note", "p85α regulatory, most abundant"]]}, {"symbol": "PIK3R2", "props": [["Full name", "Phosphatidylinositol 3-kinase regulatory subunit beta"], ["Alternative names", "Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta"], ["Function", "Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology."], ["HGNC", "HGNC:8980"], ["HGNC symbol", "PIK3R2"], ["HGNC aliases", "P85B, p85, p85beta, p85-BETA"], ["Entrez", "5296"], ["Ensembl", "ENSG00000105647"], ["RefSeq", "NM_005027"], ["UniProt", "O00459"], ["Note", "p85β regulatory, broad expression"]]}, {"symbol": "PIK3R3", "props": [["Full name", "Phosphatidylinositol 3-kinase regulatory subunit gamma"], ["Alternative names", "Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; p55PIK"], ["Function", "Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1"], ["HGNC", "HGNC:8981"], ["HGNC symbol", "PIK3R3"], ["HGNC aliases", "p55"], ["Entrez", "8503"], ["Ensembl", "ENSG00000117461"], ["RefSeq", "NM_003629"], ["UniProt", "Q92569"], ["Note", "p55γ regulatory, brain and testis"]]}] horizontal PI3Kα horizontal horizontal Pro-epidermal growth factor EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Membrane HGNC:3229 EGF 1950 ENSG00000138798 NM_001178130 P01133 Epidermal growth factor https://www.uniprot.org/uniprotkb/P01133 EGF LABEL Pro-epidermal growth factor EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Membrane HGNC:3229 EGF 1950 ENSG00000138798 NM_001178130 P01133 Epidermal growth factor horizontal https://www.uniprot.org/uniprotkb/P01133 EGF Epidermal growth factor receptor Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1 Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Cell membrane, Endoplasmic reticulum membrane, Golgi apparatus membrane, Nucleus membrane, Endosome, Endosome membrane, Nucleus, Secreted HGNC:3236 EGFR ERBB1, ERRP, ERBB 1956 ENSG00000146648 NM_005228 P00533 EGF receptor horizontal https://www.uniprot.org/uniprotkb/P00533 EGFR Growth factor receptor-bound protein 2 Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2 Non-enzymatic adapter protein that plays a pivotal role in precisely regulated signaling cascades from cell surface receptors to cellular responses, including signaling transduction and gene expression. Thus, participates in many biological processes including regulation of innate and adaptive immunity, autophagy, DNA repair or necroptosis. Nucleus, Cytoplasm, Endosome, Golgi apparatus HGNC:4566 GRB2 NCKAP2 2885 ENSG00000177885 NM_002086 P62993 Adaptor protein horizontal https://www.uniprot.org/uniprotkb/P62993 GRB2 LABEL Growth factor receptor-bound protein 2 Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2 Non-enzymatic adapter protein that plays a pivotal role in precisely regulated signaling cascades from cell surface receptors to cellular responses, including signaling transduction and gene expression. Thus, participates in many biological processes including regulation of innate and adaptive immunity, autophagy, DNA repair or necroptosis. Nucleus, Cytoplasm, Endosome, Golgi apparatus HGNC:4566 GRB2 NCKAP2 2885 ENSG00000177885 NM_002086 P62993 Adaptor protein horizontal https://www.uniprot.org/uniprotkb/P62993 GRB2 GRB2-associated-binding protein 1 GRB2-associated binder 1; Growth factor receptor bound protein 2-associated protein 1 Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. HGNC:4066 GAB1 DFNB26 2549 ENSG00000109458 NM_002039 Q13480 Adaptor recruiting PI3K https://www.uniprot.org/uniprotkb/Q13480 GAB1 N:2 LABEL N:2 Pro-epidermal growth factor EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Membrane HGNC:3229 EGF 1950 ENSG00000138798 NM_001178130 P01133 Epidermal growth factor horizontal https://www.uniprot.org/uniprotkb/P01133 EGF Epidermal growth factor receptor Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1 Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Cell membrane, Endoplasmic reticulum membrane, Golgi apparatus membrane, Nucleus membrane, Endosome, Endosome membrane, Nucleus, Secreted HGNC:3236 EGFR ERBB1, ERRP, ERBB 1956 ENSG00000146648 NM_005228 P00533 EGF receptor horizontal https://www.uniprot.org/uniprotkb/P00533 EGFR N:2 LABEL N:2 Pro-epidermal growth factor EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Membrane HGNC:3229 EGF 1950 ENSG00000138798 NM_001178130 P01133 Epidermal growth factor horizontal https://www.uniprot.org/uniprotkb/P01133 EGF Epidermal growth factor receptor Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1 Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Cell membrane, Endoplasmic reticulum membrane, Golgi apparatus membrane, Nucleus membrane, Endosome, Endosome membrane, Nucleus, Secreted HGNC:3236 EGFR ERBB1, ERRP, ERBB 1956 ENSG00000146648 NM_005228 P00533 EGF receptor horizontal https://www.uniprot.org/uniprotkb/P00533 EGFR Epidermal growth factor receptor Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1 Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Cell membrane, Endoplasmic reticulum membrane, Golgi apparatus membrane, Nucleus membrane, Endosome, Endosome membrane, Nucleus, Secreted HGNC:3236 EGFR ERBB1, ERRP, ERBB 1956 ENSG00000146648 NM_005228 P00533 EGF receptor horizontal https://www.uniprot.org/uniprotkb/P00533 EGFR GRB2-associated-binding protein 1 GRB2-associated binder 1; Growth factor receptor bound protein 2-associated protein 1 Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. HGNC:4066 GAB1 DFNB26 2549 ENSG00000109458 NM_002039 Q13480 Adaptor recruiting PI3K https://www.uniprot.org/uniprotkb/Q13480 GAB1 LABEL Growth factor receptor-bound protein 2 Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2 Non-enzymatic adapter protein that plays a pivotal role in precisely regulated signaling cascades from cell surface receptors to cellular responses, including signaling transduction and gene expression. Thus, participates in many biological processes including regulation of innate and adaptive immunity, autophagy, DNA repair or necroptosis. Nucleus, Cytoplasm, Endosome, Golgi apparatus HGNC:4566 GRB2 NCKAP2 2885 ENSG00000177885 NM_002086 P62993 Adaptor protein horizontal https://www.uniprot.org/uniprotkb/P62993 GRB2 GRB2-associated-binding protein 1 GRB2-associated binder 1; Growth factor receptor bound protein 2-associated protein 1 Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. HGNC:4066 GAB1 DFNB26 2549 ENSG00000109458 NM_002039 Q13480 Adaptor recruiting PI3K https://www.uniprot.org/uniprotkb/Q13480 GAB1 2 active inactive @Y P@Y P@Y @Y