PI(4,5)P2 PI(3,4,5)P3 SHIP1/2 PI3P PI4P PI(3,4)P2 SYNJ1/2 INPP5B INPP5F OR PTEN INPP4A/B PI3KIα PI3KIα EGF LABEL EGF EGFR GRB2 LABEL GRB2 GAB1 N:2 LABEL N:2 EGF EGFR N:2 LABEL N:2 EGF EGFR EGFR GAB1 LABEL GRB2 GAB1 2 active inactive @Y P@Y P@Y @Y