<?xml version='1.0' encoding='UTF-8'?>
<graphml xmlns="http://graphml.graphdrawing.org/xmlns" xmlns:java="http://www.yworks.com/xml/yfiles-common/1.0/java" xmlns:sys="http://www.yworks.com/xml/yfiles-common/markup/primitives/2.0" xmlns:x="http://www.yworks.com/xml/yfiles-common/markup/2.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:y="http://www.yworks.com/xml/graphml" xmlns:yed="http://www.yworks.com/xml/yed/3" xsi:schemaLocation="http://graphml.graphdrawing.org/xmlns http://www.yworks.com/xml/schema/graphml/1.1/ygraphml.xsd">
  <!--Created by yEd 3.25.1-->
  <key attr.name="Description" attr.type="string" for="graph" id="d0"/>
  <key for="port" id="d1" yfiles.type="portgraphics"/>
  <key for="port" id="d2" yfiles.type="portgeometry"/>
  <key for="port" id="d3" yfiles.type="portuserdata"/>
  <key attr.name="HGNC" attr.type="string" for="node" id="d11"/>
  <key attr.name="HGNC symbol" attr.type="string" for="node" id="d12"/>
  <key attr.name="UniProt" attr.type="string" for="node" id="d17"/>
  <key attr.name="ChEBI" attr.type="string" for="node" id="d18"/>
  <key attr.name="Family" attr.type="string" for="node" id="d24"/>
  <key attr.name="Members" attr.type="string" for="node" id="d25"/>
  <key attr.name="Member annotation" attr.type="string" for="node" id="d26"/>
  <key attr.name="url" attr.type="string" for="node" id="d27"/>
  <key attr.name="description" attr.type="string" for="node" id="d28"/>
  <key for="node" id="d29" yfiles.type="nodegraphics"/>
  <key for="graphml" id="d30" yfiles.type="resources"/>
  <key attr.name="url" attr.type="string" for="edge" id="d31"/>
  <key attr.name="description" attr.type="string" for="edge" id="d32"/>
  <key for="edge" id="d33" yfiles.type="edgegraphics"/>
  <key attr.name="PTM" attr.type="string" for="node" id="d102"/>
  <graph edgedefault="directed" id="G">
    <data key="d0" xml:space="preserve"/>
    <node id="n0">
      <data key="d11" xml:space="preserve"/>
      <data key="d12" xml:space="preserve"/>
      <data key="d17" xml:space="preserve"/>
      <data key="d18" xml:space="preserve"/>
      <data key="d24" xml:space="preserve"/>
      <data key="d25" xml:space="preserve"/>
      <data key="d26" xml:space="preserve"/>
      <data key="d29">
        <y:GenericNode configuration="com.yworks.sbgn.Process">
          <y:Geometry height="18.0" width="18.0" x="1124.4769827474213" y="351.24870971138773"/>
          <y:Fill color="#FFFFFF" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" bottomInset="0" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="0.0" horizontalTextPosition="center" iconTextGap="4" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="0.0" x="9.0" y="9.0">
            <y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
        </y:GenericNode>
      </data>
    </node>
    <node id="n1">
      <data key="d11" xml:space="preserve"/>
      <data key="d12" xml:space="preserve"/>
      <data key="d17" xml:space="preserve"/>
      <data key="d18" xml:space="preserve"/>
      <data key="d24" xml:space="preserve"/>
      <data key="d25" xml:space="preserve">PIK3CA; PIK3CB; PIK3R1; PIK3R2; PIK3R3</data>
      <data key="d26" xml:space="preserve">[{"symbol": "PIK3CA", "props": [["HGNC", "HGNC:8975"], ["HGNC symbol", "PIK3CA"], ["UniProt", "P42336"]]}, {"symbol": "PIK3CB", "props": [["HGNC", "HGNC:8976"], ["HGNC symbol", "PIK3CB"], ["UniProt", "P42338"]]}, {"symbol": "PIK3R1", "props": [["HGNC", "HGNC:8979"], ["HGNC symbol", "PIK3R1"], ["UniProt", "P27986"]]}, {"symbol": "PIK3R2", "props": [["HGNC", "HGNC:8980"], ["HGNC symbol", "PIK3R2"], ["UniProt", "O00459"]]}, {"symbol": "PIK3R3", "props": [["HGNC", "HGNC:8981"], ["HGNC symbol", "PIK3R3"], ["UniProt", "Q92569"]]}]</data>
      <data key="d29">
        <y:GenericNode configuration="com.yworks.sbgn.Macromolecule">
          <y:Geometry height="40.0" width="80.0" x="710.6553244595167" y="172.38766333024626"/>
          <y:Fill color="#C8D8EB" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="33.763671875" x="23.1181640625" xml:space="preserve" y="9.755859375">PI3K<y:LabelModel><y:SmartNodeLabelModel distance="4.0"/></y:LabelModel><y:ModelParameter><y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/></y:ModelParameter></y:NodeLabel>
          <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="0.0" bottomInset="0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="18.0" horizontalTextPosition="center" iconData="1" iconTextGap="0" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="45.0" x="17.5" y="-9.0">
            <y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="-0.5" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
          <y:StyleProperties>
            <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radius" value="10"/>
          </y:StyleProperties>
        </y:GenericNode>
      </data>
    </node>
    <node id="n2">
      <data key="d11" xml:space="preserve"/>
      <data key="d12" xml:space="preserve"/>
      <data key="d17" xml:space="preserve"/>
      <data key="d18" xml:space="preserve"/>
      <data key="d24" xml:space="preserve"/>
      <data key="d25" xml:space="preserve">PIK3CA; PIK3CB; PIK3R1; PIK3R2; PIK3R3</data>
      <data key="d26" xml:space="preserve">[{"symbol": "PIK3CA", "props": [["HGNC", "HGNC:8975"], ["HGNC symbol", "PIK3CA"], ["UniProt", "P42336"]]}, {"symbol": "PIK3CB", "props": [["HGNC", "HGNC:8976"], ["HGNC symbol", "PIK3CB"], ["UniProt", "P42338"]]}, {"symbol": "PIK3R1", "props": [["HGNC", "HGNC:8979"], ["HGNC symbol", "PIK3R1"], ["UniProt", "P27986"]]}, {"symbol": "PIK3R2", "props": [["HGNC", "HGNC:8980"], ["HGNC symbol", "PIK3R2"], ["UniProt", "O00459"]]}, {"symbol": "PIK3R3", "props": [["HGNC", "HGNC:8981"], ["HGNC symbol", "PIK3R3"], ["UniProt", "Q92569"]]}]</data>
      <data key="d29">
        <y:GenericNode configuration="com.yworks.sbgn.Macromolecule">
          <y:Geometry height="40.0" width="80.0" x="710.6553244595167" y="38.572589188549046"/>
          <y:Fill color="#C8D8EB" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="33.763671875" x="23.1181640625" xml:space="preserve" y="9.755859375">PI3K<y:LabelModel><y:SmartNodeLabelModel distance="4.0"/></y:LabelModel><y:ModelParameter><y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/></y:ModelParameter></y:NodeLabel>
          <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="0.0" bottomInset="0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="18.0" horizontalTextPosition="center" iconData="2" iconTextGap="0" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="45.0" x="17.5" y="-9.111328125">
            <y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.00618489583333337" nodeRatioX="0.0" nodeRatioY="-0.5" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
          <y:StyleProperties>
            <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radius" value="10"/>
          </y:StyleProperties>
        </y:GenericNode>
      </data>
    </node>
    <node id="n3">
      <data key="d11" xml:space="preserve"/>
      <data key="d12" xml:space="preserve"/>
      <data key="d17" xml:space="preserve"/>
      <data key="d18" xml:space="preserve"/>
      <data key="d24" xml:space="preserve"/>
      <data key="d25" xml:space="preserve"/>
      <data key="d26" xml:space="preserve"/>
      <data key="d29">
        <y:GenericNode configuration="com.yworks.sbgn.Process">
          <y:Geometry height="18.0" width="18.0" x="741.6553244595167" y="108.57258918854905"/>
          <y:Fill color="#FFFFFF" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" bottomInset="0" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="0.0" horizontalTextPosition="center" iconTextGap="4" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="0.0" x="9.0" y="9.0">
            <y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
        </y:GenericNode>
      </data>
    </node>
    <node id="n4">
      <data key="d11" xml:space="preserve"/>
      <data key="d12" xml:space="preserve"/>
      <data key="d17" xml:space="preserve"/>
      <data key="d18" xml:space="preserve">CHEBI:58456</data>
      <data key="d24" xml:space="preserve"/>
      <data key="d25" xml:space="preserve"/>
      <data key="d26" xml:space="preserve"/>
      <data key="d29">
        <y:GenericNode configuration="com.yworks.sbgn.SimpleChemical">
          <y:Geometry height="32.0" width="110.0" x="593.7235862674671" y="265.14652261703964"/>
          <y:Fill color="#DBEBDB" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="68.0322265625" x="20.98388671875" xml:space="preserve" y="5.755859375">PI(4,5)P2 <y:LabelModel><y:SmartNodeLabelModel distance="4.0"/></y:LabelModel><y:ModelParameter><y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/></y:ModelParameter></y:NodeLabel>
        </y:GenericNode>
      </data>
    </node>
    <node id="n5">
      <data key="d11" xml:space="preserve"/>
      <data key="d12" xml:space="preserve"/>
      <data key="d17" xml:space="preserve"/>
      <data key="d18" xml:space="preserve">CHEBI:57836</data>
      <data key="d24" xml:space="preserve"/>
      <data key="d25" xml:space="preserve"/>
      <data key="d26" xml:space="preserve"/>
      <data key="d29">
        <y:GenericNode configuration="com.yworks.sbgn.SimpleChemical">
          <y:Geometry height="32.0" width="110.0" x="805.6553244595167" y="265.37252261703964"/>
          <y:Fill color="#DBEBDB" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="81.314453125" x="14.3427734375" xml:space="preserve" y="5.755859375">PI(3,4,5)P3 <y:LabelModel><y:SmartNodeLabelModel distance="4.0"/></y:LabelModel><y:ModelParameter><y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/></y:ModelParameter></y:NodeLabel>
        </y:GenericNode>
      </data>
    </node>
    <node id="n6">
      <data key="d11" xml:space="preserve"/>
      <data key="d12" xml:space="preserve"/>
      <data key="d17" xml:space="preserve"/>
      <data key="d18" xml:space="preserve"/>
      <data key="d24" xml:space="preserve"/>
      <data key="d25" xml:space="preserve"/>
      <data key="d26" xml:space="preserve"/>
      <data key="d29">
        <y:GenericNode configuration="com.yworks.sbgn.Process">
          <y:Geometry height="18.0" width="18.0" x="741.6553244595167" y="271.63452261703964"/>
          <y:Fill color="#FFFFFF" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" bottomInset="0" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="0.0" horizontalTextPosition="center" iconTextGap="4" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="0.0" x="9.0" y="9.0">
            <y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
        </y:GenericNode>
      </data>
    </node>
    <node id="n7">
      <data key="d11" xml:space="preserve"/>
      <data key="d12" xml:space="preserve"/>
      <data key="d17" xml:space="preserve"/>
      <data key="d18" xml:space="preserve"/>
      <data key="d24" xml:space="preserve"/>
      <data key="d25" xml:space="preserve"/>
      <data key="d26" xml:space="preserve"/>
      <data key="d29">
        <y:GenericNode configuration="com.yworks.sbgn.Process">
          <y:Geometry height="18.0" width="18.0" x="911.3552092932096" y="352.2271535724756"/>
          <y:Fill color="#FFFFFF" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" bottomInset="0" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="0.0" horizontalTextPosition="center" iconTextGap="4" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="0.0" x="9.0" y="9.0">
            <y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
        </y:GenericNode>
      </data>
    </node>
    <node id="n8" yfiles.foldertype="group">
      <data key="d11" xml:space="preserve"/>
      <data key="d12" xml:space="preserve"/>
      <data key="d17" xml:space="preserve"/>
      <data key="d18" xml:space="preserve"/>
      <data key="d24" xml:space="preserve"/>
      <data key="d25" xml:space="preserve"/>
      <data key="d26" xml:space="preserve"/>
      <data key="d29">
        <y:ProxyAutoBoundsNode>
          <y:Realizers active="0">
            <y:GenericGroupNode configuration="com.yworks.sbgn.Complex">
              <y:Geometry height="124.0" width="134.0" x="962.1206192770292" y="297.49870971138773"/>
              <y:Fill color="#FFFFFF" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="8.0" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="4.0" horizontalTextPosition="center" iconTextGap="4" modelName="internal" modelPosition="t" textColor="#000000" verticalTextPosition="bottom" visible="true" width="4.0" x="65.0" y="8.0"/>
              <y:StyleProperties>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusY" value="12"/>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusX" value="12"/>
              </y:StyleProperties>
              <y:State autoResize="true" closed="false" closedHeight="80.0" closedWidth="80.0"/>
              <y:Insets bottom="14" bottomF="14.0" left="10" leftF="10.0" right="10" rightF="10.0" top="10" topF="10.0"/>
              <y:BorderInsets bottom="7" bottomF="7.0" left="2" leftF="2.0" right="2" rightF="2.0" top="0" topF="0.0"/>
            </y:GenericGroupNode>
            <y:GenericGroupNode configuration="com.yworks.sbgn.Complex">
              <y:Geometry height="80.0" width="80.0" x="-111.40504926124055" y="-332.78377057205614"/>
              <y:Fill color="#FFFFFF" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="8.0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="18.1328125" horizontalTextPosition="center" iconTextGap="4" modelName="internal" modelPosition="t" textColor="#000000" verticalTextPosition="bottom" visible="true" width="38.482421875" x="20.7587890625" xml:space="preserve" y="8.0">LABEL</y:NodeLabel>
              <y:StyleProperties>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusY" value="12"/>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusX" value="12"/>
              </y:StyleProperties>
              <y:State autoResize="true" closed="true" closedHeight="80.0" closedWidth="80.0"/>
              <y:Insets bottom="14" bottomF="14.0" left="10" leftF="10.0" right="10" rightF="10.0" top="10" topF="10.0"/>
              <y:BorderInsets bottom="7" bottomF="7.0" left="2" leftF="2.0" right="2" rightF="2.0" top="0" topF="0.0"/>
            </y:GenericGroupNode>
          </y:Realizers>
        </y:ProxyAutoBoundsNode>
      </data>
      <graph edgedefault="directed" id="n8:">
        <node id="n8::n0">
          <data key="d11" xml:space="preserve"/>
          <data key="d12" xml:space="preserve"/>
          <data key="d17" xml:space="preserve"/>
          <data key="d18" xml:space="preserve">CHEBI:57836</data>
          <data key="d24" xml:space="preserve"/>
          <data key="d25" xml:space="preserve"/>
          <data key="d26" xml:space="preserve"/>
          <data key="d29">
            <y:GenericNode configuration="com.yworks.sbgn.SimpleChemical">
              <y:Geometry height="32.0" width="110.0" x="974.1206192770292" y="311.49870971138773"/>
              <y:Fill color="#DBEBDB" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="81.314453125" x="14.3427734375" xml:space="preserve" y="5.755859375">PI(3,4,5)P3 <y:LabelModel><y:SmartNodeLabelModel distance="4.0"/></y:LabelModel><y:ModelParameter><y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/></y:ModelParameter></y:NodeLabel>
            </y:GenericNode>
          </data>
        </node>
        <node id="n8::n1">
          <data key="d11" xml:space="preserve"/>
          <data key="d12" xml:space="preserve"/>
          <data key="d17" xml:space="preserve"/>
          <data key="d18" xml:space="preserve"/>
          <data key="d24" xml:space="preserve"/>
          <data key="d25" xml:space="preserve">AKT1; AKT2; AKT3</data>
          <data key="d26" xml:space="preserve">[{"symbol": "AKT1", "props": [["HGNC", "HGNC:391"], ["HGNC symbol", "AKT1"], ["UniProt", "P31749"]]}, {"symbol": "AKT2", "props": [["HGNC", "HGNC:392"], ["HGNC symbol", "AKT2"], ["UniProt", "P31751"]]}, {"symbol": "AKT3", "props": [["HGNC", "HGNC:393"], ["HGNC symbol", "AKT3"], ["UniProt", "Q9Y243"]]}]</data>
          <data key="d29">
            <y:GenericNode configuration="com.yworks.sbgn.Macromolecule">
              <y:Geometry height="40.0" width="80.0" x="989.1206192770292" y="351.49870971138773"/>
              <y:Fill color="#C8D8EB" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="31.6513671875" x="24.17431640625" xml:space="preserve" y="9.755859375">AKT<y:LabelModel><y:SmartNodeLabelModel distance="4.0"/></y:LabelModel><y:ModelParameter><y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/></y:ModelParameter></y:NodeLabel>
              <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="0.0" bottomInset="0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="18.0" horizontalTextPosition="center" iconData="3" iconTextGap="0" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="18.0" x="11.0" y="31.0">
                <y:LabelModel>
                  <y:SmartNodeLabelModel distance="4.0"/>
                </y:LabelModel>
                <y:ModelParameter>
                  <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="-0.25" nodeRatioY="0.5" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
                </y:ModelParameter>
              </y:NodeLabel>
              <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="0.0" bottomInset="0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="18.0" horizontalTextPosition="center" iconData="3" iconTextGap="0" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="18.0" x="51.0" y="31.0">
                <y:LabelModel>
                  <y:SmartNodeLabelModel distance="4.0"/>
                </y:LabelModel>
                <y:ModelParameter>
                  <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.25" nodeRatioY="0.5" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
                </y:ModelParameter>
              </y:NodeLabel>
              <y:StyleProperties>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radius" value="10"/>
              </y:StyleProperties>
            </y:GenericNode>
          </data>
        </node>
      </graph>
    </node>
    <node id="n9">
      <data key="d11" xml:space="preserve">HGNC:8816</data>
      <data key="d12" xml:space="preserve">PDPK1</data>
      <data key="d17" xml:space="preserve">O15530</data>
      <data key="d18" xml:space="preserve"/>
      <data key="d24" xml:space="preserve"/>
      <data key="d25" xml:space="preserve"/>
      <data key="d26" xml:space="preserve"/>
      <data key="d29">
        <y:GenericNode configuration="com.yworks.sbgn.Macromolecule">
          <y:Geometry height="40.0" width="80.0" x="820.6553244595167" y="120.31754897699699"/>
          <y:Fill color="#C8D8EB" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="47.955078125" x="16.0224609375" xml:space="preserve" y="9.755859375">PDPK1<y:LabelModel><y:SmartNodeLabelModel distance="4.0"/></y:LabelModel><y:ModelParameter><y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/></y:ModelParameter></y:NodeLabel>
          <y:StyleProperties>
            <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radius" value="10"/>
          </y:StyleProperties>
        </y:GenericNode>
      </data>
    </node>
    <node id="n10">
      <data key="d11" xml:space="preserve"/>
      <data key="d12" xml:space="preserve"/>
      <data key="d17" xml:space="preserve"/>
      <data key="d18" xml:space="preserve"/>
      <data key="d24" xml:space="preserve"/>
      <data key="d25" xml:space="preserve"/>
      <data key="d26" xml:space="preserve"/>
      <data key="d29">
        <y:GenericNode configuration="com.yworks.sbgn.Process">
          <y:Geometry height="18.0" width="18.0" x="911.3552092932096" y="203.63713196451963"/>
          <y:Fill color="#FFFFFF" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" bottomInset="0" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="0.0" horizontalTextPosition="center" iconTextGap="4" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="0.0" x="9.0" y="9.0">
            <y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
        </y:GenericNode>
      </data>
    </node>
    <node id="n11" yfiles.foldertype="group">
      <data key="d11" xml:space="preserve"/>
      <data key="d12" xml:space="preserve"/>
      <data key="d17" xml:space="preserve"/>
      <data key="d18" xml:space="preserve"/>
      <data key="d24" xml:space="preserve"/>
      <data key="d25" xml:space="preserve"/>
      <data key="d26" xml:space="preserve"/>
      <data key="d29">
        <y:ProxyAutoBoundsNode>
          <y:Realizers active="0">
            <y:GenericGroupNode configuration="com.yworks.sbgn.Complex">
              <y:Geometry height="108.0" width="134.0" x="1066.8919827474213" y="157.88713196451963"/>
              <y:Fill color="#FFFFFF" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="8.0" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="4.0" horizontalTextPosition="center" iconTextGap="4" modelName="internal" modelPosition="t" textColor="#000000" verticalTextPosition="bottom" visible="true" width="4.0" x="65.0" y="8.0"/>
              <y:StyleProperties>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusY" value="12"/>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusX" value="12"/>
              </y:StyleProperties>
              <y:State autoResize="true" closed="false" closedHeight="80.0" closedWidth="80.0"/>
              <y:Insets bottom="14" bottomF="14.0" left="10" leftF="10.0" right="10" rightF="10.0" top="10" topF="10.0"/>
              <y:BorderInsets bottom="0" bottomF="2.842170943040401e-14" left="2" leftF="2.0" right="2" rightF="2.0" top="0" topF="0.0"/>
            </y:GenericGroupNode>
            <y:GenericGroupNode configuration="com.yworks.sbgn.Complex">
              <y:Geometry height="80.0" width="80.0" x="-111.40504926124055" y="-332.78377057205614"/>
              <y:Fill color="#FFFFFF" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="8.0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="18.1328125" horizontalTextPosition="center" iconTextGap="4" modelName="internal" modelPosition="t" textColor="#000000" verticalTextPosition="bottom" visible="true" width="38.482421875" x="20.7587890625" xml:space="preserve" y="8.0">LABEL</y:NodeLabel>
              <y:StyleProperties>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusY" value="12"/>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusX" value="12"/>
              </y:StyleProperties>
              <y:State autoResize="true" closed="true" closedHeight="80.0" closedWidth="80.0"/>
              <y:Insets bottom="14" bottomF="14.0" left="10" leftF="10.0" right="10" rightF="10.0" top="10" topF="10.0"/>
              <y:BorderInsets bottom="0" bottomF="2.842170943040401e-14" left="2" leftF="2.0" right="2" rightF="2.0" top="0" topF="0.0"/>
            </y:GenericGroupNode>
          </y:Realizers>
        </y:ProxyAutoBoundsNode>
      </data>
      <graph edgedefault="directed" id="n11:">
        <node id="n11::n0">
          <data key="d11" xml:space="preserve">HGNC:8816</data>
          <data key="d12" xml:space="preserve">PDPK1</data>
          <data key="d17" xml:space="preserve">O15530</data>
          <data key="d18" xml:space="preserve"/>
          <data key="d24" xml:space="preserve"/>
          <data key="d25" xml:space="preserve"/>
          <data key="d26" xml:space="preserve"/>
          <data key="d29">
            <y:GenericNode configuration="com.yworks.sbgn.Macromolecule">
              <y:Geometry height="40.0" width="80.0" x="1093.8919827474213" y="211.88713196451963"/>
              <y:Fill color="#C8D8EB" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="47.955078125" x="16.0224609375" xml:space="preserve" y="9.755859375">PDPK1<y:LabelModel><y:SmartNodeLabelModel distance="4.0"/></y:LabelModel><y:ModelParameter><y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/></y:ModelParameter></y:NodeLabel>
              <y:StyleProperties>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radius" value="10"/>
              </y:StyleProperties>
            </y:GenericNode>
          </data>
        </node>
        <node id="n11::n1">
          <data key="d11" xml:space="preserve"/>
          <data key="d12" xml:space="preserve"/>
          <data key="d17" xml:space="preserve"/>
          <data key="d18" xml:space="preserve">CHEBI:57836</data>
          <data key="d24" xml:space="preserve"/>
          <data key="d25" xml:space="preserve"/>
          <data key="d26" xml:space="preserve"/>
          <data key="d29">
            <y:GenericNode configuration="com.yworks.sbgn.SimpleChemical">
              <y:Geometry height="32.0" width="110.0" x="1078.8919827474213" y="171.88713196451963"/>
              <y:Fill color="#DBEBDB" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="81.314453125" x="14.3427734375" xml:space="preserve" y="5.755859375">PI(3,4,5)P3 <y:LabelModel><y:SmartNodeLabelModel distance="4.0"/></y:LabelModel><y:ModelParameter><y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/></y:ModelParameter></y:NodeLabel>
            </y:GenericNode>
          </data>
        </node>
      </graph>
    </node>
    <node id="n12">
      <data key="d11" xml:space="preserve"/>
      <data key="d12" xml:space="preserve"/>
      <data key="d17" xml:space="preserve"/>
      <data key="d18" xml:space="preserve"/>
      <data key="d24" xml:space="preserve">PKA catalytic subunits</data>
      <data key="d25" xml:space="preserve">PRKACA; PRKACB; PRKACG</data>
      <data key="d26" xml:space="preserve">[{"symbol": "PRKACA", "props": [["HGNC", "HGNC:9380"], ["HGNC symbol", "PRKACA"], ["UniProt", "P17612"]]}, {"symbol": "PRKACB", "props": [["HGNC", "HGNC:9381"], ["HGNC symbol", "PRKACB"], ["UniProt", "P22694"]]}, {"symbol": "PRKACG", "props": [["HGNC", "HGNC:9382"], ["HGNC symbol", "PRKACG"], ["UniProt", "P22612"]]}]</data>
      <data key="d29">
        <y:GenericNode configuration="com.yworks.sbgn.Macromolecule">
          <y:Geometry height="40.0" width="80.0" x="1006.6467264410958" y="588.0885416249239"/>
          <y:Fill color="#C8D8EB" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="48.32421875" x="15.837890625" xml:space="preserve" y="9.755859375">PKA-C<y:LabelModel><y:SmartNodeLabelModel distance="4.0"/></y:LabelModel><y:ModelParameter><y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/></y:ModelParameter></y:NodeLabel>
          <y:StyleProperties>
            <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radius" value="10"/>
          </y:StyleProperties>
        </y:GenericNode>
      </data>
    </node>
    <node id="n13">
      <data key="d11" xml:space="preserve"/>
      <data key="d12" xml:space="preserve"/>
      <data key="d17" xml:space="preserve"/>
      <data key="d18" xml:space="preserve"/>
      <data key="d24" xml:space="preserve"/>
      <data key="d25" xml:space="preserve"/>
      <data key="d26" xml:space="preserve"/>
      <data key="d29">
        <y:GenericNode configuration="com.yworks.sbgn.Process">
          <y:Geometry height="18.0" width="18.0" x="947.6467264410958" y="599.0885416249239"/>
          <y:Fill color="#FFFFFF" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" bottomInset="0" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="0.0" horizontalTextPosition="center" iconTextGap="4" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="0.0" x="9.0" y="9.0">
            <y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
        </y:GenericNode>
      </data>
    </node>
    <node id="n14" yfiles.foldertype="group">
      <data key="d11" xml:space="preserve"/>
      <data key="d12" xml:space="preserve"/>
      <data key="d17" xml:space="preserve"/>
      <data key="d18" xml:space="preserve"/>
      <data key="d24" xml:space="preserve"/>
      <data key="d25" xml:space="preserve"/>
      <data key="d26" xml:space="preserve"/>
      <data key="d29">
        <y:ProxyAutoBoundsNode>
          <y:Realizers active="0">
            <y:GenericGroupNode configuration="com.yworks.sbgn.Complex">
              <y:Geometry height="124.0" width="134.0" x="1175.1696163213644" y="293.8259198791832"/>
              <y:Fill color="#FFFFFF" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="8.0" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="4.0" horizontalTextPosition="center" iconTextGap="4" modelName="internal" modelPosition="t" textColor="#000000" verticalTextPosition="bottom" visible="true" width="4.0" x="65.0" y="8.0"/>
              <y:StyleProperties>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusY" value="12"/>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusX" value="12"/>
              </y:StyleProperties>
              <y:State autoResize="true" closed="false" closedHeight="80.0" closedWidth="80.0"/>
              <y:Insets bottom="14" bottomF="14.0" left="10" leftF="10.0" right="10" rightF="10.0" top="10" topF="10.0"/>
              <y:BorderInsets bottom="7" bottomF="7.0" left="2" leftF="2.0" right="2" rightF="2.0" top="0" topF="0.0"/>
            </y:GenericGroupNode>
            <y:GenericGroupNode configuration="com.yworks.sbgn.Complex">
              <y:Geometry height="80.0" width="80.0" x="-111.40504926124055" y="-332.78377057205614"/>
              <y:Fill color="#FFFFFF" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="8.0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="18.1328125" horizontalTextPosition="center" iconTextGap="4" modelName="internal" modelPosition="t" textColor="#000000" verticalTextPosition="bottom" visible="true" width="38.482421875" x="20.7587890625" xml:space="preserve" y="8.0">LABEL</y:NodeLabel>
              <y:StyleProperties>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusY" value="12"/>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusX" value="12"/>
              </y:StyleProperties>
              <y:State autoResize="true" closed="true" closedHeight="80.0" closedWidth="80.0"/>
              <y:Insets bottom="14" bottomF="14.0" left="10" leftF="10.0" right="10" rightF="10.0" top="10" topF="10.0"/>
              <y:BorderInsets bottom="7" bottomF="7.0" left="2" leftF="2.0" right="2" rightF="2.0" top="0" topF="0.0"/>
            </y:GenericGroupNode>
          </y:Realizers>
        </y:ProxyAutoBoundsNode>
      </data>
      <graph edgedefault="directed" id="n14:">
        <node id="n14::n0">
          <data key="d11" xml:space="preserve"/>
          <data key="d12" xml:space="preserve"/>
          <data key="d17" xml:space="preserve"/>
          <data key="d18" xml:space="preserve">CHEBI:57836</data>
          <data key="d24" xml:space="preserve"/>
          <data key="d25" xml:space="preserve"/>
          <data key="d26" xml:space="preserve"/>
          <data key="d29">
            <y:GenericNode configuration="com.yworks.sbgn.SimpleChemical">
              <y:Geometry height="32.0" width="110.0" x="1187.1696163213644" y="307.8259198791832"/>
              <y:Fill color="#DBEBDB" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="81.314453125" x="14.3427734375" xml:space="preserve" y="5.755859375">PI(3,4,5)P3 <y:LabelModel><y:SmartNodeLabelModel distance="4.0"/></y:LabelModel><y:ModelParameter><y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/></y:ModelParameter></y:NodeLabel>
            </y:GenericNode>
          </data>
        </node>
        <node id="n14::n1">
          <data key="d11" xml:space="preserve"/>
          <data key="d12" xml:space="preserve"/>
          <data key="d17" xml:space="preserve"/>
          <data key="d18" xml:space="preserve"/>
          <data key="d24" xml:space="preserve"/>
          <data key="d25" xml:space="preserve">AKT1; AKT2; AKT3</data>
          <data key="d26" xml:space="preserve">[{"symbol": "AKT1", "props": [["HGNC", "HGNC:391"], ["HGNC symbol", "AKT1"], ["UniProt", "P31749"], ["PTM", "P@S473\nP@T308"]]}, {"symbol": "AKT2", "props": [["HGNC", "HGNC:392"], ["HGNC symbol", "AKT2"], ["UniProt", "P31751"], ["PTM", "P@S474\nP@T309"]]}, {"symbol": "AKT3", "props": [["HGNC", "HGNC:393"], ["HGNC symbol", "AKT3"], ["UniProt", "Q9Y243"], ["PTM", "P@S472\nP@T305"]]}]</data>
          <data key="d29">
            <y:GenericNode configuration="com.yworks.sbgn.Macromolecule">
              <y:Geometry height="40.0" width="80.0" x="1202.1696163213644" y="347.8259198791832"/>
              <y:Fill color="#C8D8EB" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="31.6513671875" x="24.17431640625" xml:space="preserve" y="9.755859375">AKT<y:LabelModel><y:SmartNodeLabelModel distance="4.0"/></y:LabelModel><y:ModelParameter><y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/></y:ModelParameter></y:NodeLabel>
              <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="0.0" bottomInset="0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="18.0" horizontalTextPosition="center" iconData="4" iconTextGap="0" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="18.0" x="11.0" y="31.0">
                <y:LabelModel>
                  <y:SmartNodeLabelModel distance="4.0"/>
                </y:LabelModel>
                <y:ModelParameter>
                  <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="-0.25" nodeRatioY="0.5" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
                </y:ModelParameter>
              </y:NodeLabel>
              <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="0.0" bottomInset="0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="18.0" horizontalTextPosition="center" iconData="4" iconTextGap="0" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="18.0" x="51.0" y="31.0">
                <y:LabelModel>
                  <y:SmartNodeLabelModel distance="4.0"/>
                </y:LabelModel>
                <y:ModelParameter>
                  <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.25" nodeRatioY="0.5" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
                </y:ModelParameter>
              </y:NodeLabel>
              <y:StyleProperties>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radius" value="10"/>
              </y:StyleProperties>
            </y:GenericNode>
          </data>
        </node>
      </graph>
    </node>
    <node id="n15">
      <data key="d11" xml:space="preserve">HGNC:8779</data>
      <data key="d12" xml:space="preserve">PDE3B</data>
      <data key="d17" xml:space="preserve">Q13370</data>
      <data key="d18" xml:space="preserve"/>
      <data key="d24" xml:space="preserve"/>
      <data key="d25" xml:space="preserve"/>
      <data key="d26" xml:space="preserve"/>
      <data key="d29">
        <y:GenericNode configuration="com.yworks.sbgn.Macromolecule">
          <y:Geometry height="40.0" width="80.0" x="1136.6696163213644" y="521.0885416249239"/>
          <y:Fill color="#E2ACA3" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="46.7177734375" x="16.64111328125" xml:space="preserve" y="9.755859375">PDE3B<y:LabelModel><y:SmartNodeLabelModel distance="4.0"/></y:LabelModel><y:ModelParameter><y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/></y:ModelParameter></y:NodeLabel>
          <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="0.0" bottomInset="0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="18.0" horizontalTextPosition="center" iconData="5" iconTextGap="0" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="18.0" x="12.5" y="32.0">
            <y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="-0.5" labelRatioY="-0.05555555555555558" nodeRatioX="-0.34375" nodeRatioY="0.5" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
          <y:StyleProperties>
            <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radius" value="10"/>
          </y:StyleProperties>
        </y:GenericNode>
      </data>
    </node>
    <node id="n16">
      <data key="d11" xml:space="preserve">HGNC:8779</data>
      <data key="d12" xml:space="preserve">PDE3B</data>
      <data key="d17" xml:space="preserve">Q13370</data>
      <data key="d18" xml:space="preserve"/>
      <data key="d24" xml:space="preserve"/>
      <data key="d25" xml:space="preserve"/>
      <data key="d26" xml:space="preserve"/>
      <data key="d102">P@S295</data><data key="d29">
        <y:GenericNode configuration="com.yworks.sbgn.Macromolecule">
          <y:Geometry height="40.0" width="80.0" x="1136.6696163213644" y="655.0885416249239"/>
          <y:Fill color="#E2ACA3" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="46.7177734375" x="16.64111328125" xml:space="preserve" y="9.755859375">PDE3B<y:LabelModel><y:SmartNodeLabelModel distance="4.0"/></y:LabelModel><y:ModelParameter><y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/></y:ModelParameter></y:NodeLabel>
          <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="0.0" bottomInset="0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="18.0" horizontalTextPosition="center" iconData="6" iconTextGap="0" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="18.0" x="10.5" y="31.120312500000068">
            <y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="-0.5" labelRatioY="-0.006684027777778434" nodeRatioX="-0.36875" nodeRatioY="0.5" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
          <y:StyleProperties>
            <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radius" value="10"/>
          </y:StyleProperties>
        </y:GenericNode>
      </data>
    </node>
    <node id="n17">
      <data key="d11" xml:space="preserve"/>
      <data key="d12" xml:space="preserve"/>
      <data key="d17" xml:space="preserve"/>
      <data key="d18" xml:space="preserve"/>
      <data key="d24" xml:space="preserve"/>
      <data key="d25" xml:space="preserve"/>
      <data key="d26" xml:space="preserve"/>
      <data key="d29">
        <y:GenericNode configuration="com.yworks.sbgn.Process">
          <y:Geometry height="18.0" width="18.0" x="1167.6696163213644" y="599.0885416249239"/>
          <y:Fill color="#FFFFFF" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" bottomInset="0" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="0.0" horizontalTextPosition="center" iconTextGap="4" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="0.0" x="9.0" y="9.0">
            <y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
        </y:GenericNode>
      </data>
    </node>
    <node id="n18">
      <data key="d11" xml:space="preserve"/>
      <data key="d12" xml:space="preserve"/>
      <data key="d17" xml:space="preserve"/>
      <data key="d18" xml:space="preserve">CHEBI:58165</data>
      <data key="d24" xml:space="preserve"/>
      <data key="d25" xml:space="preserve"/>
      <data key="d26" xml:space="preserve"/>
      <data key="d29">
        <y:GenericNode configuration="com.yworks.sbgn.SimpleChemical">
          <y:Geometry height="32.0" width="60.0" x="672.5943915028463" y="733.0885416249239"/>
          <y:Fill color="#DBEBDB" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="40.626953125" x="9.6865234375" xml:space="preserve" y="5.755859375">cAMP<y:LabelModel><y:SmartNodeLabelModel distance="4.0"/></y:LabelModel><y:ModelParameter><y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/></y:ModelParameter></y:NodeLabel>
        </y:GenericNode>
      </data>
    </node>
    <node id="n19">
      <data key="d11" xml:space="preserve"/>
      <data key="d12" xml:space="preserve"/>
      <data key="d17" xml:space="preserve"/>
      <data key="d18" xml:space="preserve">CHEBI:456215</data>
      <data key="d24" xml:space="preserve"/>
      <data key="d25" xml:space="preserve"/>
      <data key="d26" xml:space="preserve"/>
      <data key="d29">
        <y:GenericNode configuration="com.yworks.sbgn.SimpleChemical">
          <y:Geometry height="32.0" width="60.0" x="1247.1696163213644" y="733.0885416249239"/>
          <y:Fill color="#DBEBDB" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="33.4560546875" x="13.27197265625" xml:space="preserve" y="5.755859375">AMP<y:LabelModel><y:SmartNodeLabelModel distance="4.0"/></y:LabelModel><y:ModelParameter><y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/></y:ModelParameter></y:NodeLabel>
        </y:GenericNode>
      </data>
    </node>
    <node id="n20">
      <data key="d11" xml:space="preserve"/>
      <data key="d12" xml:space="preserve"/>
      <data key="d17" xml:space="preserve"/>
      <data key="d18" xml:space="preserve"/>
      <data key="d24" xml:space="preserve"/>
      <data key="d25" xml:space="preserve"/>
      <data key="d26" xml:space="preserve"/>
      <data key="d29">
        <y:GenericNode configuration="com.yworks.sbgn.Process">
          <y:Geometry height="18.0" width="18.0" x="1167.6696163213644" y="740.0885416249239"/>
          <y:Fill color="#FFFFFF" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" bottomInset="0" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="0.0" horizontalTextPosition="center" iconTextGap="4" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="0.0" x="9.0" y="9.0">
            <y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
        </y:GenericNode>
      </data>
    </node>
    <node id="n21">
      <data key="d11" xml:space="preserve"/>
      <data key="d12" xml:space="preserve"/>
      <data key="d17" xml:space="preserve"/>
      <data key="d18" xml:space="preserve"/>
      <data key="d24" xml:space="preserve"/>
      <data key="d25" xml:space="preserve">AKT1; AKT2; AKT3</data>
      <data key="d26" xml:space="preserve">[{"symbol": "AKT1", "props": [["HGNC", "HGNC:391"], ["HGNC symbol", "AKT1"], ["UniProt", "P31749"]]}, {"symbol": "AKT2", "props": [["HGNC", "HGNC:392"], ["HGNC symbol", "AKT2"], ["UniProt", "P31751"]]}, {"symbol": "AKT3", "props": [["HGNC", "HGNC:393"], ["HGNC symbol", "AKT3"], ["UniProt", "Q9Y243"]]}]</data>
      <data key="d29">
        <y:GenericNode configuration="com.yworks.sbgn.Macromolecule">
          <y:Geometry height="40.0" width="80.0" x="783.2907583850414" y="341.2271535724756"/>
          <y:Fill color="#C8D8EB" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="31.6513671875" x="24.17431640625" xml:space="preserve" y="9.755859375">AKT<y:LabelModel><y:SmartNodeLabelModel distance="4.0"/></y:LabelModel><y:ModelParameter><y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/></y:ModelParameter></y:NodeLabel>
          <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="0.0" bottomInset="0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="18.0" horizontalTextPosition="center" iconData="3" iconTextGap="0" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="18.0" x="11.0" y="31.0">
            <y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="-0.25" nodeRatioY="0.5" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
          <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="0.0" bottomInset="0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="18.0" horizontalTextPosition="center" iconData="3" iconTextGap="0" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="18.0" x="51.0" y="31.0">
            <y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.25" nodeRatioY="0.5" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
          <y:StyleProperties>
            <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radius" value="10"/>
          </y:StyleProperties>
        </y:GenericNode>
      </data>
    </node>
    <node id="n22" yfiles.foldertype="group">
      <data key="d11" xml:space="preserve"/>
      <data key="d12" xml:space="preserve"/>
      <data key="d17" xml:space="preserve"/>
      <data key="d18" xml:space="preserve"/>
      <data key="d24" xml:space="preserve"/>
      <data key="d25" xml:space="preserve"/>
      <data key="d26" xml:space="preserve"/>
      <data key="d29">
        <y:ProxyAutoBoundsNode>
          <y:Realizers active="0">
            <y:GenericGroupNode configuration="com.yworks.sbgn.Complex">
              <y:Geometry height="140.0" width="112.0" x="573.5943915028463" y="538.0885416249239"/>
              <y:Fill color="#FFFFFF" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="8.0" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="4.0" horizontalTextPosition="center" iconTextGap="4" modelName="internal" modelPosition="t" textColor="#000000" verticalTextPosition="bottom" visible="true" width="4.0" x="54.0" y="8.0"/>
              <y:StyleProperties>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusY" value="12"/>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusX" value="12"/>
              </y:StyleProperties>
              <y:State autoResize="true" closed="false" closedHeight="80.0" closedWidth="80.0"/>
              <y:Insets bottom="14" bottomF="14.0" left="10" leftF="10.0" right="10" rightF="10.0" top="2" topF="2.0"/>
              <y:BorderInsets bottom="2" bottomF="2.0" left="2" leftF="2.0" right="4" rightF="4.0" top="0" topF="0.0"/>
            </y:GenericGroupNode>
            <y:GenericGroupNode configuration="com.yworks.sbgn.Complex">
              <y:Geometry height="80.0" width="80.0" x="1180.9682452684979" y="1649.721616018271"/>
              <y:Fill color="#FFFFFF" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="8.0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="18.1328125" horizontalTextPosition="center" iconTextGap="4" modelName="internal" modelPosition="t" textColor="#000000" verticalTextPosition="bottom" visible="true" width="38.482421875" x="20.7587890625" xml:space="preserve" y="8.0">LABEL</y:NodeLabel>
              <y:StyleProperties>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusY" value="12"/>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusX" value="12"/>
              </y:StyleProperties>
              <y:State autoResize="true" closed="true" closedHeight="80.0" closedWidth="80.0"/>
              <y:Insets bottom="14" bottomF="14.0" left="10" leftF="10.0" right="10" rightF="10.0" top="10" topF="10.0"/>
              <y:BorderInsets bottom="2" bottomF="2.0" left="2" leftF="2.0" right="4" rightF="4.0" top="0" topF="0.0"/>
            </y:GenericGroupNode>
          </y:Realizers>
        </y:ProxyAutoBoundsNode>
      </data>
      <graph edgedefault="directed" id="n22:">
        <node id="n22::n0">
          <data key="d11" xml:space="preserve"/>
          <data key="d12" xml:space="preserve"/>
          <data key="d17" xml:space="preserve"/>
          <data key="d18" xml:space="preserve"/>
          <data key="d24" xml:space="preserve">PKA regulatory subunits</data>
          <data key="d25" xml:space="preserve">PRKAR1A; PRKAR1B; PRKAR2A; PRKAR2B</data>
          <data key="d26" xml:space="preserve">[{"symbol": "PRKAR1A", "props": [["HGNC", "HGNC:9388"], ["HGNC symbol", "PRKAR1A"], ["UniProt", "P10644"]]}, {"symbol": "PRKAR1B", "props": [["HGNC", "HGNC:9390"], ["HGNC symbol", "PRKAR1B"], ["UniProt", "P31321"]]}, {"symbol": "PRKAR2A", "props": [["HGNC", "HGNC:9391"], ["HGNC symbol", "PRKAR2A"], ["UniProt", "P13861"]]}, {"symbol": "PRKAR2B", "props": [["HGNC", "HGNC:9392"], ["HGNC symbol", "PRKAR2B"], ["UniProt", "P31323"]]}]</data>
          <data key="d29">
            <y:GenericNode configuration="com.yworks.sbgn.Macromolecule">
              <y:Geometry height="40.0" width="80.0" x="585.5943915028463" y="552.0885416249239"/>
              <y:Fill color="#C2D4ED" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="47.490234375" x="16.2548828125" xml:space="preserve" y="9.755859375">PKA-R<y:LabelModel><y:SmartNodeLabelModel distance="4.0"/></y:LabelModel><y:ModelParameter><y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/></y:ModelParameter></y:NodeLabel>
              <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="0.0" bottomInset="0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="16.0" horizontalTextPosition="center" iconData="7" iconTextGap="0" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="24.875" x="27.5625" y="-8.0">
                <y:LabelModel>
                  <y:SmartNodeLabelModel distance="4.0"/>
                </y:LabelModel>
                <y:ModelParameter>
                  <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="-0.5" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
                </y:ModelParameter>
              </y:NodeLabel>
              <y:StyleProperties>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.mcount" value="2"/>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radius" value="10"/>
              </y:StyleProperties>
            </y:GenericNode>
          </data>
        </node>
        <node id="n22::n1">
          <data key="d11" xml:space="preserve"/>
          <data key="d12" xml:space="preserve"/>
          <data key="d17" xml:space="preserve"/>
          <data key="d18" xml:space="preserve"/>
          <data key="d24" xml:space="preserve">PKA catalytic subunits</data>
          <data key="d25" xml:space="preserve">PRKACA; PRKACB; PRKACG</data>
          <data key="d26" xml:space="preserve">[{"symbol": "PRKACA", "props": [["HGNC", "HGNC:9380"], ["HGNC symbol", "PRKACA"], ["UniProt", "P17612"]]}, {"symbol": "PRKACB", "props": [["HGNC", "HGNC:9381"], ["HGNC symbol", "PRKACB"], ["UniProt", "P22694"]]}, {"symbol": "PRKACG", "props": [["HGNC", "HGNC:9382"], ["HGNC symbol", "PRKACG"], ["UniProt", "P22612"]]}]</data>
          <data key="d29">
            <y:GenericNode configuration="com.yworks.sbgn.Macromolecule">
              <y:Geometry height="40.0" width="80.0" x="585.5943915028463" y="616.0885416249239"/>
              <y:Fill color="#C2D4ED" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="48.32421875" x="15.837890625" xml:space="preserve" y="9.755859375">PKA-C<y:LabelModel><y:SmartNodeLabelModel distance="4.0"/></y:LabelModel><y:ModelParameter><y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/></y:ModelParameter></y:NodeLabel>
              <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="0.0" bottomInset="0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="16.0" horizontalTextPosition="center" iconData="8" iconTextGap="0" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="24.875" x="27.5625" y="-8.0">
                <y:LabelModel>
                  <y:SmartNodeLabelModel distance="4.0"/>
                </y:LabelModel>
                <y:ModelParameter>
                  <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="-0.5" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
                </y:ModelParameter>
              </y:NodeLabel>
              <y:StyleProperties>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.mcount" value="2"/>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radius" value="10"/>
              </y:StyleProperties>
            </y:GenericNode>
          </data>
        </node>
      </graph>
    </node>
    <node id="n23">
      <data key="d11" xml:space="preserve"/>
      <data key="d12" xml:space="preserve"/>
      <data key="d17" xml:space="preserve"/>
      <data key="d18" xml:space="preserve"/>
      <data key="d24" xml:space="preserve"/>
      <data key="d25" xml:space="preserve"/>
      <data key="d26" xml:space="preserve"/>
      <data key="d29">
        <y:GenericNode configuration="com.yworks.sbgn.Process">
          <y:Geometry height="18.0" width="18.0" x="719.5476526693694" y="599.0885416249239"/>
          <y:Fill color="#FFFFFF" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" bottomInset="0" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="0.0" horizontalTextPosition="center" iconTextGap="4" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="0.0" x="9.0" y="9.0">
            <y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
        </y:GenericNode>
      </data>
    </node>
    <node id="n24" yfiles.foldertype="group">
      <data key="d11" xml:space="preserve"/>
      <data key="d12" xml:space="preserve"/>
      <data key="d17" xml:space="preserve"/>
      <data key="d18" xml:space="preserve"/>
      <data key="d24" xml:space="preserve"/>
      <data key="d25" xml:space="preserve"/>
      <data key="d26" xml:space="preserve"/>
      <data key="d29">
        <y:ProxyAutoBoundsNode>
          <y:Realizers active="0">
            <y:GenericGroupNode configuration="com.yworks.sbgn.Complex">
              <y:Geometry height="216.0" width="136.0" x="774.5971895552326" y="500.0885416249239"/>
              <y:Fill color="#FFFFFF" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="8.0" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="4.0" horizontalTextPosition="center" iconTextGap="4" modelName="internal" modelPosition="t" textColor="#000000" verticalTextPosition="bottom" visible="true" width="4.0" x="66.0" y="8.0"/>
              <y:StyleProperties>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusY" value="12"/>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusX" value="12"/>
              </y:StyleProperties>
              <y:State autoResize="false" closed="false" closedHeight="80.0" closedWidth="80.0"/>
              <y:Insets bottom="14" bottomF="14.0" left="10" leftF="10.0" right="10" rightF="10.0" top="10" topF="10.0"/>
              <y:BorderInsets bottom="0" bottomF="0.0" left="2" leftF="2.0" right="2" rightF="2.0" top="0" topF="0.0"/>
            </y:GenericGroupNode>
            <y:GenericGroupNode configuration="com.yworks.sbgn.Complex">
              <y:Geometry height="80.0" width="80.0" x="1403.9682452684979" y="1431.4069560320333"/>
              <y:Fill color="#FFFFFF" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="8.0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="18.1328125" horizontalTextPosition="center" iconTextGap="4" modelName="internal" modelPosition="t" textColor="#000000" verticalTextPosition="bottom" visible="true" width="38.482421875" x="20.7587890625" xml:space="preserve" y="8.0">LABEL</y:NodeLabel>
              <y:StyleProperties>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusY" value="12"/>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusX" value="12"/>
              </y:StyleProperties>
              <y:State autoResize="true" closed="true" closedHeight="80.0" closedWidth="80.0"/>
              <y:Insets bottom="14" bottomF="14.0" left="10" leftF="10.0" right="10" rightF="10.0" top="10" topF="10.0"/>
              <y:BorderInsets bottom="0" bottomF="0.0" left="2" leftF="2.0" right="2" rightF="2.0" top="0" topF="0.0"/>
            </y:GenericGroupNode>
          </y:Realizers>
        </y:ProxyAutoBoundsNode>
      </data>
      <graph edgedefault="directed" id="n24:">
        <node id="n24::n0" yfiles.foldertype="group">
          <data key="d11" xml:space="preserve"/>
          <data key="d12" xml:space="preserve"/>
          <data key="d17" xml:space="preserve"/>
          <data key="d18" xml:space="preserve"/>
          <data key="d24" xml:space="preserve"/>
          <data key="d25" xml:space="preserve"/>
          <data key="d26" xml:space="preserve"/>
          <data key="d29">
            <y:ProxyAutoBoundsNode>
              <y:Realizers active="0">
                <y:GenericGroupNode configuration="com.yworks.sbgn.Complex">
                  <y:Geometry height="124.0" width="112.0" x="786.5971895552326" y="514.0885416249239"/>
                  <y:Fill color="#FFFFFF" transparent="false"/>
                  <y:BorderStyle color="#000000" type="line" width="1.0"/>
                  <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="8.0" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="4.0" horizontalTextPosition="center" iconTextGap="4" modelName="internal" modelPosition="t" textColor="#000000" verticalTextPosition="bottom" visible="true" width="4.0" x="54.0" y="8.0"/>
                  <y:StyleProperties>
                    <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusY" value="12"/>
                    <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusX" value="12"/>
                  </y:StyleProperties>
                  <y:State autoResize="false" closed="false" closedHeight="80.0" closedWidth="80.0"/>
                  <y:Insets bottom="14" bottomF="14.0" left="10" leftF="10.0" right="10" rightF="10.0" top="10" topF="10.0"/>
                  <y:BorderInsets bottom="2" bottomF="2.0" left="2" leftF="2.0" right="4" rightF="4.0" top="0" topF="0.0"/>
                </y:GenericGroupNode>
                <y:GenericGroupNode configuration="com.yworks.sbgn.Complex">
                  <y:Geometry height="80.0" width="80.0" x="1449.7830019403973" y="1447.6455336592142"/>
                  <y:Fill color="#FFFFFF" transparent="false"/>
                  <y:BorderStyle color="#000000" type="line" width="1.0"/>
                  <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="8.0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="18.1328125" horizontalTextPosition="center" iconTextGap="4" modelName="internal" modelPosition="t" textColor="#000000" verticalTextPosition="bottom" visible="true" width="38.482421875" x="20.7587890625" xml:space="preserve" y="8.0">LABEL</y:NodeLabel>
                  <y:StyleProperties>
                    <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusY" value="12"/>
                    <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusX" value="12"/>
                  </y:StyleProperties>
                  <y:State autoResize="true" closed="true" closedHeight="80.0" closedWidth="80.0"/>
                  <y:Insets bottom="14" bottomF="14.0" left="10" leftF="10.0" right="10" rightF="10.0" top="10" topF="10.0"/>
                  <y:BorderInsets bottom="2" bottomF="2.0" left="2" leftF="2.0" right="4" rightF="4.0" top="0" topF="0.0"/>
                </y:GenericGroupNode>
              </y:Realizers>
            </y:ProxyAutoBoundsNode>
          </data>
          <graph edgedefault="directed" id="n24::n0:">
            <node id="n24::n0::n0">
              <data key="d11" xml:space="preserve"/>
              <data key="d12" xml:space="preserve"/>
              <data key="d17" xml:space="preserve"/>
              <data key="d18" xml:space="preserve"/>
              <data key="d24" xml:space="preserve">PKA regulatory subunits</data>
              <data key="d25" xml:space="preserve">PRKAR1A; PRKAR1B; PRKAR2A; PRKAR2B</data>
              <data key="d26" xml:space="preserve">[{"symbol": "PRKAR1A", "props": [["HGNC", "HGNC:9388"], ["HGNC symbol", "PRKAR1A"], ["UniProt", "P10644"]]}, {"symbol": "PRKAR1B", "props": [["HGNC", "HGNC:9390"], ["HGNC symbol", "PRKAR1B"], ["UniProt", "P31321"]]}, {"symbol": "PRKAR2A", "props": [["HGNC", "HGNC:9391"], ["HGNC symbol", "PRKAR2A"], ["UniProt", "P13861"]]}, {"symbol": "PRKAR2B", "props": [["HGNC", "HGNC:9392"], ["HGNC symbol", "PRKAR2B"], ["UniProt", "P31323"]]}]</data>
              <data key="d29">
                <y:GenericNode configuration="com.yworks.sbgn.Macromolecule">
                  <y:Geometry height="40.0" width="80.0" x="798.5971895552326" y="576.0885416249239"/>
                  <y:Fill color="#C2D4ED" transparent="false"/>
                  <y:BorderStyle color="#000000" type="line" width="1.0"/>
                  <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="47.490234375" x="16.2548828125" xml:space="preserve" y="9.755859375">PKA-R<y:LabelModel><y:SmartNodeLabelModel distance="4.0"/></y:LabelModel><y:ModelParameter><y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/></y:ModelParameter></y:NodeLabel>
                  <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="0.0" bottomInset="0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="16.0" horizontalTextPosition="center" iconData="9" iconTextGap="0" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="24.875" x="27.5625" y="-8.0">
                    <y:LabelModel>
                      <y:SmartNodeLabelModel distance="4.0"/>
                    </y:LabelModel>
                    <y:ModelParameter>
                      <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="-0.5" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
                    </y:ModelParameter>
                  </y:NodeLabel>
                  <y:StyleProperties>
                    <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.mcount" value="2"/>
                    <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radius" value="10"/>
                  </y:StyleProperties>
                </y:GenericNode>
              </data>
            </node>
            <node id="n24::n0::n1">
              <data key="d11" xml:space="preserve"/>
              <data key="d12" xml:space="preserve"/>
              <data key="d17" xml:space="preserve"/>
              <data key="d18" xml:space="preserve">CHEBI:58165</data>
              <data key="d24" xml:space="preserve"/>
              <data key="d25" xml:space="preserve"/>
              <data key="d26" xml:space="preserve"/>
              <data key="d29">
                <y:GenericNode configuration="com.yworks.sbgn.SimpleChemical">
                  <y:Geometry height="32.0" width="60.0" x="808.5971895552326" y="528.0885416249239"/>
                  <y:Fill color="#DBEBDB" transparent="false"/>
                  <y:BorderStyle color="#000000" type="line" width="1.0"/>
                  <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="40.626953125" x="9.6865234375" xml:space="preserve" y="5.755859375">cAMP<y:LabelModel><y:SmartNodeLabelModel distance="4.0"/></y:LabelModel><y:ModelParameter><y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/></y:ModelParameter></y:NodeLabel>
                </y:GenericNode>
              </data>
            </node>
          </graph>
        </node>
        <node id="n24::n1">
          <data key="d11" xml:space="preserve"/>
          <data key="d12" xml:space="preserve"/>
          <data key="d17" xml:space="preserve"/>
          <data key="d18" xml:space="preserve"/>
          <data key="d24" xml:space="preserve">PKA catalytic subunits</data>
          <data key="d25" xml:space="preserve">PRKACA; PRKACB; PRKACG</data>
          <data key="d26" xml:space="preserve">[{"symbol": "PRKACA", "props": [["HGNC", "HGNC:9380"], ["HGNC symbol", "PRKACA"], ["UniProt", "P17612"]]}, {"symbol": "PRKACB", "props": [["HGNC", "HGNC:9381"], ["HGNC symbol", "PRKACB"], ["UniProt", "P22694"]]}, {"symbol": "PRKACG", "props": [["HGNC", "HGNC:9382"], ["HGNC symbol", "PRKACG"], ["UniProt", "P22612"]]}]</data>
          <data key="d29">
            <y:GenericNode configuration="com.yworks.sbgn.Macromolecule">
              <y:Geometry height="40.0" width="80.0" x="802.5971895552326" y="656.0885416249239"/>
              <y:Fill color="#C2D4ED" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="48.32421875" x="15.837890625" xml:space="preserve" y="9.755859375">PKA-C<y:LabelModel><y:SmartNodeLabelModel distance="4.0"/></y:LabelModel><y:ModelParameter><y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/></y:ModelParameter></y:NodeLabel>
              <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="0.0" bottomInset="0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="16.0" horizontalTextPosition="center" iconData="10" iconTextGap="0" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="24.875" x="27.5625" y="-8.0">
                <y:LabelModel>
                  <y:SmartNodeLabelModel distance="4.0"/>
                </y:LabelModel>
                <y:ModelParameter>
                  <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="-0.5" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
                </y:ModelParameter>
              </y:NodeLabel>
              <y:StyleProperties>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.mcount" value="2"/>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radius" value="10"/>
              </y:StyleProperties>
            </y:GenericNode>
          </data>
        </node>
      </graph>
    </node>
    <node id="n25" yfiles.foldertype="group">
      <data key="d11" xml:space="preserve"/>
      <data key="d12" xml:space="preserve"/>
      <data key="d17" xml:space="preserve"/>
      <data key="d18" xml:space="preserve"/>
      <data key="d24" xml:space="preserve"/>
      <data key="d25" xml:space="preserve"/>
      <data key="d26" xml:space="preserve"/>
      <data key="d29">
        <y:ProxyAutoBoundsNode>
          <y:Realizers active="0">
            <y:GenericGroupNode configuration="com.yworks.sbgn.Complex">
              <y:Geometry height="132.0" width="112.0" x="924.6467264410958" y="437.6650656148961"/>
              <y:Fill color="#FFFFFF" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="8.0" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="4.0" horizontalTextPosition="center" iconTextGap="4" modelName="internal" modelPosition="t" textColor="#000000" verticalTextPosition="bottom" visible="true" width="4.0" x="54.0" y="8.0"/>
              <y:StyleProperties>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusY" value="12"/>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusX" value="12"/>
              </y:StyleProperties>
              <y:State autoResize="false" closed="false" closedHeight="80.0" closedWidth="80.0"/>
              <y:Insets bottom="14" bottomF="14.0" left="10" leftF="10.0" right="10" rightF="10.0" top="10" topF="10.0"/>
              <y:BorderInsets bottom="6" bottomF="6.0" left="2" leftF="2.0" right="4" rightF="4.0" top="0" topF="0.0"/>
            </y:GenericGroupNode>
            <y:GenericGroupNode configuration="com.yworks.sbgn.Complex">
              <y:Geometry height="80.0" width="80.0" x="1473.3094896959167" y="1429.4847468725065"/>
              <y:Fill color="#FFFFFF" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="8.0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="18.1328125" horizontalTextPosition="center" iconTextGap="4" modelName="internal" modelPosition="t" textColor="#000000" verticalTextPosition="bottom" visible="true" width="38.482421875" x="20.7587890625" xml:space="preserve" y="8.0">LABEL</y:NodeLabel>
              <y:StyleProperties>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusY" value="12"/>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusX" value="12"/>
              </y:StyleProperties>
              <y:State autoResize="true" closed="true" closedHeight="80.0" closedWidth="80.0"/>
              <y:Insets bottom="14" bottomF="14.0" left="10" leftF="10.0" right="10" rightF="10.0" top="10" topF="10.0"/>
              <y:BorderInsets bottom="6" bottomF="6.0" left="2" leftF="2.0" right="4" rightF="4.0" top="0" topF="0.0"/>
            </y:GenericGroupNode>
          </y:Realizers>
        </y:ProxyAutoBoundsNode>
      </data>
      <graph edgedefault="directed" id="n25:">
        <node id="n25::n0">
          <data key="d11" xml:space="preserve"/>
          <data key="d12" xml:space="preserve"/>
          <data key="d17" xml:space="preserve"/>
          <data key="d18" xml:space="preserve"/>
          <data key="d24" xml:space="preserve">PKA regulatory subunits</data>
          <data key="d25" xml:space="preserve">PRKAR1A; PRKAR1B; PRKAR2A; PRKAR2B</data>
          <data key="d26" xml:space="preserve">[{"symbol": "PRKAR1A", "props": [["HGNC", "HGNC:9388"], ["HGNC symbol", "PRKAR1A"], ["UniProt", "P10644"]]}, {"symbol": "PRKAR1B", "props": [["HGNC", "HGNC:9390"], ["HGNC symbol", "PRKAR1B"], ["UniProt", "P31321"]]}, {"symbol": "PRKAR2A", "props": [["HGNC", "HGNC:9391"], ["HGNC symbol", "PRKAR2A"], ["UniProt", "P13861"]]}, {"symbol": "PRKAR2B", "props": [["HGNC", "HGNC:9392"], ["HGNC symbol", "PRKAR2B"], ["UniProt", "P31323"]]}]</data>
          <data key="d29">
            <y:GenericNode configuration="com.yworks.sbgn.Macromolecule">
              <y:Geometry height="40.0" width="80.0" x="936.6467264410958" y="503.66506561489604"/>
              <y:Fill color="#C2D4ED" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="47.490234375" x="16.2548828125" xml:space="preserve" y="9.755859375">PKA-R<y:LabelModel><y:SmartNodeLabelModel distance="4.0"/></y:LabelModel><y:ModelParameter><y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/></y:ModelParameter></y:NodeLabel>
              <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="0.0" bottomInset="0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="16.0" horizontalTextPosition="center" iconData="11" iconTextGap="0" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="24.875" x="27.5625" y="-8.0">
                <y:LabelModel>
                  <y:SmartNodeLabelModel distance="4.0"/>
                </y:LabelModel>
                <y:ModelParameter>
                  <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="-0.5" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
                </y:ModelParameter>
              </y:NodeLabel>
              <y:StyleProperties>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radius" value="10"/>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.mcount" value="2"/>
              </y:StyleProperties>
            </y:GenericNode>
          </data>
        </node>
        <node id="n25::n1">
          <data key="d11" xml:space="preserve"/>
          <data key="d12" xml:space="preserve"/>
          <data key="d17" xml:space="preserve"/>
          <data key="d18" xml:space="preserve">CHEBI:58165</data>
          <data key="d24" xml:space="preserve"/>
          <data key="d25" xml:space="preserve"/>
          <data key="d26" xml:space="preserve"/>
          <data key="d29">
            <y:GenericNode configuration="com.yworks.sbgn.SimpleChemical">
              <y:Geometry height="32.0" width="60.0" x="946.6467264410958" y="451.6650656148961"/>
              <y:Fill color="#DBEBDB" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="40.626953125" x="9.6865234375" xml:space="preserve" y="5.755859375">cAMP<y:LabelModel><y:SmartNodeLabelModel distance="4.0"/></y:LabelModel><y:ModelParameter><y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/></y:ModelParameter></y:NodeLabel>
            </y:GenericNode>
          </data>
        </node>
      </graph>
    </node>
    <edge id="e0" source="n2" target="n3">
      <data key="d33">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="none"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e1" source="n3" target="n1">
      <data key="d33">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="-27.76509677969588"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="delta"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e2" source="n4" target="n6">
      <data key="d33">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="none"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e3" source="n6" target="n5">
      <data key="d33">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="delta"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e4" source="n7" target="n8">
      <data key="d33">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="-51.615609879967664" ty="0.9784438610878116"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="delta"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e5" source="n0" target="n8">
      <data key="d33">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="none"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e6" source="n9" target="n10">
      <data key="d33">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="0.0">
            <y:Point x="897.649684898045" y="212.63713196451963"/>
          </y:Path>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="none"/>
          <y:EdgeLabel alignment="center" configuration="AutoFlippingLabel" distance="2.0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="4.0" horizontalTextPosition="center" iconTextGap="4" modelName="custom" preferredPlacement="anywhere" ratio="0.5" textColor="#000000" verticalTextPosition="bottom" visible="true" width="4.0" x="-15.337891795675432" y="37.80013920625481">
            <y:LabelModel>
              <y:SmartEdgeLabelModel autoRotationEnabled="false" defaultAngle="0.0" defaultDistance="10.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartEdgeLabelModelParameter angle="0.0" distance="30.0" distanceToCenter="true" position="right" ratio="0.5" segment="0"/>
            </y:ModelParameter>
            <y:PreferredPlacementDescriptor angle="0.0" angleOffsetOnRightSide="0" angleReference="absolute" angleRotationOnRightSide="co" distance="-1.0" frozen="true" placement="anywhere" side="anywhere" sideReference="relative_to_edge_flow"/>
          </y:EdgeLabel>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e7" source="n5" target="n10">
      <data key="d33">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="0.0">
            <y:Point x="897.649684898045" y="212.63713196451963"/>
          </y:Path>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="none"/>
          <y:EdgeLabel alignment="center" configuration="AutoFlippingLabel" distance="2.0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="4.0" horizontalTextPosition="center" iconTextGap="4" modelName="custom" preferredPlacement="anywhere" ratio="0.5" textColor="#000000" verticalTextPosition="bottom" visible="true" width="4.0" x="44.3133056053141" y="-24.749550842423673">
            <y:LabelModel>
              <y:SmartEdgeLabelModel autoRotationEnabled="false" defaultAngle="0.0" defaultDistance="10.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartEdgeLabelModelParameter angle="0.0" distance="30.0" distanceToCenter="true" position="right" ratio="0.5" segment="0"/>
            </y:ModelParameter>
            <y:PreferredPlacementDescriptor angle="0.0" angleOffsetOnRightSide="0" angleReference="absolute" angleRotationOnRightSide="co" distance="-1.0" frozen="true" placement="anywhere" side="anywhere" sideReference="relative_to_edge_flow"/>
          </y:EdgeLabel>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e8" source="n10" target="n11">
      <data key="d33">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="delta"/>
          <y:EdgeLabel alignment="center" configuration="AutoFlippingLabel" distance="2.0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="4.0" horizontalTextPosition="center" iconTextGap="4" modelName="custom" preferredPlacement="anywhere" ratio="0.5" textColor="#000000" verticalTextPosition="bottom" visible="true" width="4.0" x="64.32813529817338" y="27.767223602676864">
            <y:LabelModel>
              <y:SmartEdgeLabelModel autoRotationEnabled="false" defaultAngle="0.0" defaultDistance="10.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartEdgeLabelModelParameter angle="0.0" distance="30.0" distanceToCenter="true" position="right" ratio="0.5" segment="0"/>
            </y:ModelParameter>
            <y:PreferredPlacementDescriptor angle="0.0" angleOffsetOnRightSide="0" angleReference="absolute" angleRotationOnRightSide="co" distance="-1.0" frozen="true" placement="anywhere" side="anywhere" sideReference="relative_to_edge_flow"/>
          </y:EdgeLabel>
          <y:BendStyle smoothed="true"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e9" source="n11" target="n0">
      <data key="d33">
        <y:PolyLineEdge>
          <y:Path sx="0.11775451575624629" sy="54.0" tx="1.1275000000000546" ty="-9.03125"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="white_circle"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e10" source="n5" target="n7">
      <data key="d33">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="0.0">
            <y:Point x="894.9063384871387" y="361.2271535724756"/>
          </y:Path>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="none"/>
          <y:EdgeLabel alignment="center" configuration="AutoFlippingLabel" distance="2.0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="4.0" horizontalTextPosition="center" iconTextGap="4" modelName="custom" preferredPlacement="anywhere" ratio="0.5" textColor="#000000" verticalTextPosition="bottom" visible="true" width="4.0" x="-15.887662036558368" y="41.72742659421863">
            <y:LabelModel>
              <y:SmartEdgeLabelModel autoRotationEnabled="false" defaultAngle="0.0" defaultDistance="10.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartEdgeLabelModelParameter angle="0.0" distance="30.0" distanceToCenter="true" position="right" ratio="0.5" segment="0"/>
            </y:ModelParameter>
            <y:PreferredPlacementDescriptor angle="0.0" angleOffsetOnRightSide="0" angleReference="absolute" angleRotationOnRightSide="co" distance="-1.0" frozen="true" placement="anywhere" side="anywhere" sideReference="relative_to_edge_flow"/>
          </y:EdgeLabel>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e11" source="n22" target="n23">
      <data key="d33">
        <y:PolyLineEdge>
          <y:Path sx="56.0" sy="0.0" tx="-9.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="none"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e12" source="n13" target="n12">
      <data key="d33">
        <y:PolyLineEdge>
          <y:Path sx="9.0" sy="0.0" tx="-40.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="delta"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e13" source="n1" target="n6">
      <data key="d33">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="white_circle"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e14" source="n0" target="n14">
      <data key="d33">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="-57.34313084405858" ty="3.6727898322045576"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="delta"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e15" source="n15" target="n17">
      <data key="d33">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="none"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e16" source="n17" target="n16">
      <data key="d33">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="delta"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e17" source="n14" target="n17">
      <data key="d33">
        <y:PolyLineEdge>
          <y:Path sx="2.1647138289961276" sy="43.78687065807014" tx="0.0" ty="0.0">
            <y:Point x="1244.3343301503605" y="608.0885416249239"/>
          </y:Path>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="white_circle"/>
          <y:EdgeLabel alignment="center" configuration="AutoFlippingLabel" distance="2.0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="4.0" horizontalTextPosition="center" iconTextGap="4" modelName="custom" preferredPlacement="anywhere" ratio="0.5" textColor="#000000" verticalTextPosition="bottom" visible="true" width="4.0" x="-32.00002043557697" y="97.9287500889036">
            <y:LabelModel>
              <y:SmartEdgeLabelModel autoRotationEnabled="false" defaultAngle="0.0" defaultDistance="10.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartEdgeLabelModelParameter angle="0.0" distance="30.0" distanceToCenter="true" position="right" ratio="0.5" segment="0"/>
            </y:ModelParameter>
            <y:PreferredPlacementDescriptor angle="0.0" angleOffsetOnRightSide="0" angleReference="absolute" angleRotationOnRightSide="co" distance="-1.0" frozen="true" placement="anywhere" side="anywhere" sideReference="relative_to_edge_flow"/>
          </y:EdgeLabel>
          <y:BendStyle smoothed="true"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e18" source="n16" target="n20">
      <data key="d33">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="20.0" tx="0.0" ty="-9.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="white_circle"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e19" source="n18" target="n20">
      <data key="d33">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="none"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e20" source="n20" target="n19">
      <data key="d33">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="delta"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e21" source="n21" target="n7">
      <data key="d33">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="0.0">
            <y:Point x="894.9063384871387" y="361.2271535724756"/>
          </y:Path>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="none"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e22" source="n18" target="n23">
      <data key="d33">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="-14.5" tx="0.0" ty="0.0">
            <y:Point x="702.5943915028463" y="608.0885416249239"/>
          </y:Path>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="none"/>
          <y:EdgeLabel alignment="center" configuration="AutoFlippingLabel" distance="2.0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="4.0" horizontalTextPosition="center" iconTextGap="4" modelName="custom" preferredPlacement="anywhere" ratio="0.5" textColor="#000000" verticalTextPosition="bottom" visible="true" width="4.0" x="28.245961357977535" y="-70.54040290279727">
            <y:LabelModel>
              <y:SmartEdgeLabelModel autoRotationEnabled="false" defaultAngle="0.0" defaultDistance="10.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartEdgeLabelModelParameter angle="0.0" distance="28.245991241849968" distanceToCenter="false" position="right" ratio="0.5216414252547871" segment="0"/>
            </y:ModelParameter>
            <y:PreferredPlacementDescriptor angle="0.0" angleOffsetOnRightSide="0" angleReference="absolute" angleRotationOnRightSide="co" distance="-1.0" frozen="true" placement="anywhere" side="anywhere" sideReference="relative_to_edge_flow"/>
          </y:EdgeLabel>
          <y:BendStyle smoothed="true"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e23" source="n12" target="n17">
      <data key="d33">
        <y:PolyLineEdge>
          <y:Path sx="40.0" sy="0.0" tx="-9.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="white_circle"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e24" source="n23" target="n24">
      <data key="d33">
        <y:PolyLineEdge>
          <y:Path sx="9.0" sy="0.0" tx="-68.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="delta"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e25" source="n24" target="n13">
      <data key="d33">
        <y:PolyLineEdge>
          <y:Path sx="68.0" sy="0.0" tx="-9.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="none"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e26" source="n13" target="n25">
      <data key="d33">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="-66.0">
            <y:Point x="980.6467264410958" y="608.0885416249239"/>
          </y:Path>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="delta"/>
          <y:EdgeLabel alignment="center" configuration="AutoFlippingLabel" distance="2.0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="4.0" horizontalTextPosition="center" iconTextGap="4" modelName="custom" preferredPlacement="anywhere" ratio="0.5" textColor="#000000" verticalTextPosition="bottom" visible="true" width="4.0" x="38.628657927212544" y="2.1364247517126387">
            <y:LabelModel>
              <y:SmartEdgeLabelModel autoRotationEnabled="false" defaultAngle="0.0" defaultDistance="10.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartEdgeLabelModelParameter angle="0.0" distance="23.58178500174172" distanceToCenter="false" position="right" ratio="-4.13644513850754" segment="-1"/>
            </y:ModelParameter>
            <y:PreferredPlacementDescriptor angle="0.0" angleOffsetOnRightSide="0" angleReference="absolute" angleRotationOnRightSide="co" distance="-1.0" frozen="true" placement="anywhere" side="anywhere" sideReference="relative_to_edge_flow"/>
          </y:EdgeLabel>
          <y:BendStyle smoothed="true"/>
        </y:PolyLineEdge>
      </data>
    </edge>
  </graph>
  <data key="d30">
    <y:Resources>
      <y:Resource id="1">
        <yed:NodeRealizerIcon>
          <y:GenericNode configuration="com.yworks.sbgn.StateVariable">
            <y:Geometry height="18.0" width="45.0" x="0.0" y="0.0"/>
            <y:Fill color="#FFFFFF" transparent="false"/>
            <y:BorderStyle color="#000000" type="line" width="1.0"/>
            <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="10" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="15.77734375" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="32.0224609375" x="6.48876953125" xml:space="preserve" y="1.111328125">active<y:LabelModel><y:SmartNodeLabelModel distance="4.0"/></y:LabelModel><y:ModelParameter><y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/></y:ModelParameter></y:NodeLabel>
          </y:GenericNode>
        </yed:NodeRealizerIcon>
      </y:Resource>
      <y:Resource id="2">
        <yed:NodeRealizerIcon>
          <y:GenericNode configuration="com.yworks.sbgn.StateVariable">
            <y:Geometry height="18.0" width="45.0" x="0.0" y="0.0"/>
            <y:Fill color="#FFFFFF" transparent="false"/>
            <y:BorderStyle color="#000000" type="line" width="1.0"/>
            <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="10" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="15.77734375" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="41.119140625" x="1.9404296875" xml:space="preserve" y="1.111328125">inactive<y:LabelModel><y:SmartNodeLabelModel distance="4.0"/></y:LabelModel><y:ModelParameter><y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/></y:ModelParameter></y:NodeLabel>
          </y:GenericNode>
        </yed:NodeRealizerIcon>
      </y:Resource>
      <y:Resource id="3">
        <yed:NodeRealizerIcon>
          <y:GenericNode configuration="com.yworks.sbgn.StateVariable">
            <y:Geometry height="18.0" width="18.0" x="0.0" y="0.0"/>
            <y:Fill color="#FFFFFF" transparent="false"/>
            <y:BorderStyle color="#000000" type="line" width="1.0"/>
          </y:GenericNode>
        </yed:NodeRealizerIcon>
      </y:Resource>
      <y:Resource id="4">
        <yed:NodeRealizerIcon>
          <y:GenericNode configuration="com.yworks.sbgn.StateVariable">
            <y:Geometry height="18.0" width="18.0" x="0.0" y="0.0"/>
            <y:Fill color="#FFFFFF" transparent="false"/>
            <y:BorderStyle color="#000000" type="line" width="1.0"/>
            <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="10" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="15.77734375" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="9.52734375" x="4.236328125" xml:space="preserve" y="1.111328125">P<y:LabelModel><y:SmartNodeLabelModel distance="4.0"/></y:LabelModel><y:ModelParameter><y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/></y:ModelParameter></y:NodeLabel>
          </y:GenericNode>
        </yed:NodeRealizerIcon>
      </y:Resource>
      <y:Resource id="5">
        <yed:NodeRealizerIcon>
          <y:GenericNode configuration="com.yworks.sbgn.StateVariable">
            <y:Geometry height="18.0" width="18.0" x="0.0" y="0.0"/>
            <y:Fill color="#FFFFFF" transparent="false"/>
            <y:BorderStyle color="#000000" type="line" width="1.0"/>
          </y:GenericNode>
        </yed:NodeRealizerIcon>
      </y:Resource>
      <y:Resource id="6">
        <yed:NodeRealizerIcon>
          <y:GenericNode configuration="com.yworks.sbgn.StateVariable">
            <y:Geometry height="18.0" width="18.0" x="0.0" y="0.0"/>
            <y:Fill color="#FFFFFF" transparent="false"/>
            <y:BorderStyle color="#000000" type="line" width="1.0"/>
            <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="10" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="15.77734375" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="9.52734375" x="4.236328125" xml:space="preserve" y="1.111328125">P<y:LabelModel><y:SmartNodeLabelModel distance="4.0"/></y:LabelModel><y:ModelParameter><y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/></y:ModelParameter></y:NodeLabel>
          </y:GenericNode>
        </yed:NodeRealizerIcon>
      </y:Resource>
      <y:Resource id="7">
        <yed:NodeRealizerIcon>
          <y:ShapeNode>
            <y:Geometry height="16.0" width="24.875" x="0.0" y="0.0"/>
            <y:Fill color="#FFFFFF" transparent="false"/>
            <y:BorderStyle color="#000000" type="line" width="1.0"/>
            <y:NodeLabel alignment="center" autoSizePolicy="content" bottomInset="2" fontFamily="Dialog" fontSize="10" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="15.77734375" horizontalTextPosition="center" iconTextGap="0" leftInset="4" modelName="internal" modelPosition="c" rightInset="4" textColor="#000000" topInset="2" verticalTextPosition="center" visible="true" width="24.875" x="0.0" xml:space="preserve" y="0.111328125">N:2</y:NodeLabel>
            <y:Shape type="rectangle"/>
          </y:ShapeNode>
        </yed:NodeRealizerIcon>
      </y:Resource>
      <y:Resource id="8">
        <yed:NodeRealizerIcon>
          <y:ShapeNode>
            <y:Geometry height="16.0" width="24.875" x="0.0" y="0.0"/>
            <y:Fill color="#FFFFFF" transparent="false"/>
            <y:BorderStyle color="#000000" type="line" width="1.0"/>
            <y:NodeLabel alignment="center" autoSizePolicy="content" bottomInset="2" fontFamily="Dialog" fontSize="10" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="15.77734375" horizontalTextPosition="center" iconTextGap="0" leftInset="4" modelName="internal" modelPosition="c" rightInset="4" textColor="#000000" topInset="2" verticalTextPosition="center" visible="true" width="24.875" x="0.0" xml:space="preserve" y="0.111328125">N:2</y:NodeLabel>
            <y:Shape type="rectangle"/>
          </y:ShapeNode>
        </yed:NodeRealizerIcon>
      </y:Resource>
      <y:Resource id="9">
        <yed:NodeRealizerIcon>
          <y:ShapeNode>
            <y:Geometry height="16.0" width="24.875" x="0.0" y="0.0"/>
            <y:Fill color="#FFFFFF" transparent="false"/>
            <y:BorderStyle color="#000000" type="line" width="1.0"/>
            <y:NodeLabel alignment="center" autoSizePolicy="content" bottomInset="2" fontFamily="Dialog" fontSize="10" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="15.77734375" horizontalTextPosition="center" iconTextGap="0" leftInset="4" modelName="internal" modelPosition="c" rightInset="4" textColor="#000000" topInset="2" verticalTextPosition="center" visible="true" width="24.875" x="0.0" xml:space="preserve" y="0.111328125">N:2</y:NodeLabel>
            <y:Shape type="rectangle"/>
          </y:ShapeNode>
        </yed:NodeRealizerIcon>
      </y:Resource>
      <y:Resource id="10">
        <yed:NodeRealizerIcon>
          <y:ShapeNode>
            <y:Geometry height="16.0" width="24.875" x="0.0" y="0.0"/>
            <y:Fill color="#FFFFFF" transparent="false"/>
            <y:BorderStyle color="#000000" type="line" width="1.0"/>
            <y:NodeLabel alignment="center" autoSizePolicy="content" bottomInset="2" fontFamily="Dialog" fontSize="10" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="15.77734375" horizontalTextPosition="center" iconTextGap="0" leftInset="4" modelName="internal" modelPosition="c" rightInset="4" textColor="#000000" topInset="2" verticalTextPosition="center" visible="true" width="24.875" x="0.0" xml:space="preserve" y="0.111328125">N:2</y:NodeLabel>
            <y:Shape type="rectangle"/>
          </y:ShapeNode>
        </yed:NodeRealizerIcon>
      </y:Resource>
      <y:Resource id="11">
        <yed:NodeRealizerIcon>
          <y:ShapeNode>
            <y:Geometry height="16.0" width="24.875" x="0.0" y="0.0"/>
            <y:Fill color="#FFFFFF" transparent="false"/>
            <y:BorderStyle color="#000000" type="line" width="1.0"/>
            <y:NodeLabel alignment="center" autoSizePolicy="content" bottomInset="2" fontFamily="Dialog" fontSize="10" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="15.77734375" horizontalTextPosition="center" iconTextGap="0" leftInset="4" modelName="internal" modelPosition="c" rightInset="4" textColor="#000000" topInset="2" verticalTextPosition="center" visible="true" width="24.875" x="0.0" xml:space="preserve" y="0.111328125">N:2</y:NodeLabel>
            <y:Shape type="rectangle"/>
          </y:ShapeNode>
        </yed:NodeRealizerIcon>
      </y:Resource>
    </y:Resources>
  </data>
</graphml>