NUCLEUS LABEL Serine/threonine-protein kinase STK11 Liver kinase B1; Renal carcinoma antigen NY-REN-19 Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Nucleus, Cytoplasm, Membrane, Mitochondrion, Late endosome HGNC:11389 STK11 PJS, LKB1 6794 ENSG00000118046 NM_000455 Q15831 AMPK upstream kinase https://www.uniprot.org/uniprotkb/Q15831 LKB1 Serine/threonine-protein kinase STK11 Liver kinase B1; Renal carcinoma antigen NY-REN-19 Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Nucleus, Cytoplasm, Membrane, Mitochondrion, Late endosome HGNC:11389 STK11 PJS, LKB1 6794 ENSG00000118046 NM_000455 Q15831 AMPK upstream kinase https://www.uniprot.org/uniprotkb/Q15831 P@S428 LKB1 PRKACA; PRKACB; PRKACG [{"symbol": "PRKACA", "props": [["Full name", "cAMP-dependent protein kinase catalytic subunit alpha"], ["Function", "Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, histone H1.4 (H1-4), PSMC5/RPT6, PJA2, RYR2, RORA, SLC6A6, SOX9, UHRF1 and VASP."], ["Location", "Cytoplasm, Cell membrane, Membrane, Nucleus, Mitochondrion, Cell projection, cilium, flagellum, Cytoplasmic vesicle, secretory vesicle, acrosome"], ["HGNC", "HGNC:9380"], ["HGNC symbol", "PRKACA"], ["Alias symbols", "PKACa"], ["Entrez", "5566"], ["Ensembl", "ENSG00000072062"], ["RefSeq", "NM_002730"], ["UniProt", "P17612"], ["Note", "Cα, ubiquitous"]]}, {"symbol": "PRKACB", "props": [["Full name", "cAMP-dependent protein kinase catalytic subunit beta"], ["Function", "Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux."], ["Location", "Cytoplasm, Cell membrane, Membrane, Nucleus"], ["HGNC", "HGNC:9381"], ["HGNC symbol", "PRKACB"], ["Alias symbols", "PKACb"], ["Entrez", "5567"], ["Ensembl", "ENSG00000142875"], ["RefSeq", "NM_182948"], ["UniProt", "P22694"], ["Note", "Cβ, ubiquitous, high in brain"]]}, {"symbol": "PRKACG", "props": [["Full name", "cAMP-dependent protein kinase catalytic subunit gamma"], ["Function", "Phosphorylates a large number of substrates in the cytoplasm and the nucleus"], ["HGNC", "HGNC:9382"], ["HGNC symbol", "PRKACG"], ["Alias symbols", "PKACg"], ["Entrez", "5568"], ["Ensembl", "ENSG00000165059"], ["RefSeq", "NM_002732"], ["UniProt", "P22612"], ["Note", "Cγ, testis"]]}] PKA-C Acetyl-CoA carboxylase 2 ACC-beta Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism. Catalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. Mitochondrion HGNC:85 ACACB HACC275, ACC2, ACCB, ACC-beta, ACCbeta, ACACbeta 32 ENSG00000076555 NM_001093 O00763 Acetyl-CoA carboxylase 2, muscle and heart https://www.uniprot.org/uniprotkb/O00763 ACACB Acetyl-CoA carboxylase 2 ACC-beta Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism. Catalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. Mitochondrion HGNC:85 ACACB HACC275, ACC2, ACCB, ACC-beta, ACCbeta, ACACbeta 32 ENSG00000076555 NM_001093 O00763 Acetyl-CoA carboxylase 2, muscle and heart https://www.uniprot.org/uniprotkb/O00763 P@S222 ACACB acetyl-CoA(4-) 3'-phosphonatoadenosine 5'-(3-{(3R)-4-[(3-{[2-(acetylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl} diphosphate); AcCoA(4-); acetyl-CoA tetraanion; acetyl-CoA; acetyl-coenzyme A(4-) An acyl-CoA(4−) that is the tetraanion of acetyl-CoA, arising from deprotonation of the phosphate and diphosphate OH groups. C23H34N7O17P3S CHEBI:57288 InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 ZSLZBFCDCINBPY-ZSJPKINUSA-J https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:57288 acetyl-CoA malonyl-CoA(5-) 3'-phosphonatoadenosine 5'-{3-[(3R)-4-{[3-({2-[(3-carboxylatoacetyl)sulfanyl]ethyl}amino)-3-oxopropyl]amino}-3-hydroxy-2,2-dimethyl-4-oxobutyl] diphosphate}; malonyl-CoA Pentaanion of malonyl-CoA arising from deprotonation of phosphate, diphosphate and carboxylic acid functions. C24H33N7O19P3S CHEBI:57384 InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 LTYOQGRJFJAKNA-DVVLENMVSA-I https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:57384 malonyl-CoA LABEL CPT1A; CPT1B [{"symbol": "CPT1A", "props": [["Full name", "Carnitine O-palmitoyltransferase 1, liver isoform"], ["Alternative names", "Carnitine O-palmitoyltransferase I, liver isoform; Carnitine palmitoyltransferase 1A; Succinyltransferase CPT1A"], ["Function", "Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Also possesses a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase activity."], ["Location", "Mitochondrion outer membrane"], ["HGNC", "HGNC:2328"], ["HGNC symbol", "CPT1A"], ["Previous symbols", "CPT1"], ["Alias symbols", "CPT1-L, L-CPT1"], ["Entrez", "1374"], ["Ensembl", "ENSG00000110090"], ["RefSeq", "NM_001876"], ["UniProt", "P50416"], ["Note", "Liver isoform"]]}, {"symbol": "CPT1B", "props": [["Full name", "Carnitine O-palmitoyltransferase 1, muscle isoform"], ["Alternative names", "Carnitine O-palmitoyltransferase I, muscle isoform; Carnitine palmitoyltransferase 1B; Carnitine palmitoyltransferase I-like protein"], ["Function", "Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion"], ["Location", "Mitochondrion outer membrane"], ["HGNC", "HGNC:2329"], ["HGNC symbol", "CPT1B"], ["Alias symbols", "M-CPT1, CPT1-M"], ["Entrez", "1375"], ["Ensembl", "ENSG00000205560"], ["RefSeq", "NM_152246"], ["UniProt", "Q92523"], ["Note", "Muscle and heart isoform"]]}] CPT1 malonyl-CoA(5-) 3'-phosphonatoadenosine 5'-{3-[(3R)-4-{[3-({2-[(3-carboxylatoacetyl)sulfanyl]ethyl}amino)-3-oxopropyl]amino}-3-hydroxy-2,2-dimethyl-4-oxobutyl] diphosphate}; malonyl-CoA Pentaanion of malonyl-CoA arising from deprotonation of phosphate, diphosphate and carboxylic acid functions. C24H33N7O19P3S CHEBI:57384 InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 LTYOQGRJFJAKNA-DVVLENMVSA-I https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:57384 malonyl-CoA adenosine 5'-monophosphate(2-) 5'-O-phosphonatoadenosine; AMP dianion; AMP; AMP(2-); Adenosine-5-monophosphate dianion; Adenosine-5-monophosphate(2-) A nucleoside 5'-monophosphate(2−) that results from the removal of two protons from the phosphate group of adenosine 5'-monophosphate (AMP). C10H12N5O7P CHEBI:456215 HMDB0000045 InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 UDMBCSSLTHHNCD-KQYNXXCUSA-L https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:456215 AMP PRKAB1; PRKAB2 [{"symbol": "PRKAB1", "props": [["Full name", "5'-AMP-activated protein kinase subunit beta-1"], ["Function", "Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation."], ["HGNC", "HGNC:9378"], ["HGNC symbol", "PRKAB1"], ["Entrez", "5564"], ["Ensembl", "ENSG00000111725"], ["RefSeq", "NM_006253"], ["UniProt", "Q9Y478"], ["Note", "β1, ubiquitous, high in liver"]]}, {"symbol": "PRKAB2", "props": [["Full name", "5'-AMP-activated protein kinase subunit beta-2"], ["Function", "Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation."], ["HGNC", "HGNC:9379"], ["HGNC symbol", "PRKAB2"], ["Entrez", "5565"], ["Ensembl", "ENSG00000131791"], ["RefSeq", "NM_005399"], ["UniProt", "O43741"], ["Note", "β2, dominant in muscle"]]}] AMPKβ PRKAA1; PRKAA2 [{"symbol": "PRKAA1", "props": [["Full name", "5'-AMP-activated protein kinase catalytic subunit alpha-1"], ["Alternative names", "Acetyl-CoA carboxylase kinase; Hydroxymethylglutaryl-CoA reductase kinase; Tau-protein kinase PRKAA1"], ["Function", "Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation."], ["Location", "Cytoplasm, Nucleus, Late endosome"], ["HGNC", "HGNC:9376"], ["HGNC symbol", "PRKAA1"], ["Alias symbols", "AMPKa1"], ["Entrez", "5562"], ["Ensembl", "ENSG00000132356"], ["RefSeq", "NM_006251"], ["UniProt", "Q13131"], ["Note", "α1, ubiquitous, dominant in liver"]]}, {"symbol": "PRKAA2", "props": [["Full name", "5'-AMP-activated protein kinase catalytic subunit alpha-2"], ["Alternative names", "Acetyl-CoA carboxylase kinase; Hydroxymethylglutaryl-CoA reductase kinase"], ["Function", "Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation."], ["Location", "Cytoplasm, Nucleus, Late endosome"], ["HGNC", "HGNC:9377"], ["HGNC symbol", "PRKAA2"], ["Previous symbols", "PRKAA"], ["Alias symbols", "AMPK, AMPKa2"], ["Entrez", "5563"], ["Ensembl", "ENSG00000162409"], ["RefSeq", "NM_006252"], ["UniProt", "P54646"], ["Note", "α2, dominant in muscle and heart"]]}] AMPKα PRKAG1; PRKAG2; PRKAG3 [{"symbol": "PRKAG1", "props": [["Full name", "5'-AMP-activated protein kinase subunit gamma-1"], ["Function", "AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation."], ["HGNC", "HGNC:9385"], ["HGNC symbol", "PRKAG1"], ["Entrez", "5571"], ["Ensembl", "ENSG00000181929"], ["RefSeq", "NM_002733"], ["UniProt", "P54619"], ["Note", "γ1, ubiquitous"]]}, {"symbol": "PRKAG2", "props": [["Full name", "5'-AMP-activated protein kinase subunit gamma-2"], ["Alternative names", "H91620p"], ["Function", "AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation."], ["HGNC", "HGNC:9386"], ["HGNC symbol", "PRKAG2"], ["Alias symbols", "AAKG, AAKG2, H91620p, WPWS, CMH6"], ["Entrez", "51422"], ["Ensembl", "ENSG00000106617"], ["RefSeq", "NM_016203"], ["UniProt", "Q9UGJ0"], ["Note", "γ2, high in heart"]]}, {"symbol": "PRKAG3", "props": [["Full name", "5'-AMP-activated protein kinase subunit gamma-3"], ["Function", "AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation."], ["HGNC", "HGNC:9387"], ["HGNC symbol", "PRKAG3"], ["Entrez", "53632"], ["Ensembl", "ENSG00000115592"], ["RefSeq", "NM_017431"], ["UniProt", "Q9UGI9"], ["Note", "γ3, skeletal muscle"]]}] AMPKγ PRKAB1; PRKAB2 [{"symbol": "PRKAB1", "props": [["Full name", "5'-AMP-activated protein kinase subunit beta-1"], ["Function", "Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation."], ["HGNC", "HGNC:9378"], ["HGNC symbol", "PRKAB1"], ["Entrez", "5564"], ["Ensembl", "ENSG00000111725"], ["RefSeq", "NM_006253"], ["UniProt", "Q9Y478"], ["Note", "β1, ubiquitous, high in liver"]]}, {"symbol": "PRKAB2", "props": [["Full name", "5'-AMP-activated protein kinase subunit beta-2"], ["Function", "Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation."], ["HGNC", "HGNC:9379"], ["HGNC symbol", "PRKAB2"], ["Entrez", "5565"], ["Ensembl", "ENSG00000131791"], ["RefSeq", "NM_005399"], ["UniProt", "O43741"], ["Note", "β2, dominant in muscle"]]}] AMPKβ PRKAA1; PRKAA2 [{"symbol": "PRKAA1", "props": [["Full name", "5'-AMP-activated protein kinase catalytic subunit alpha-1"], ["Alternative names", "Acetyl-CoA carboxylase kinase; Hydroxymethylglutaryl-CoA reductase kinase; Tau-protein kinase PRKAA1"], ["Function", "Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation."], ["Location", "Cytoplasm, Nucleus, Late endosome"], ["HGNC", "HGNC:9376"], ["HGNC symbol", "PRKAA1"], ["Alias symbols", "AMPKa1"], ["Entrez", "5562"], ["Ensembl", "ENSG00000132356"], ["RefSeq", "NM_006251"], ["UniProt", "Q13131"], ["Note", "α1, ubiquitous, dominant in liver"]]}, {"symbol": "PRKAA2", "props": [["Full name", "5'-AMP-activated protein kinase catalytic subunit alpha-2"], ["Alternative names", "Acetyl-CoA carboxylase kinase; Hydroxymethylglutaryl-CoA reductase kinase"], ["Function", "Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation."], ["Location", "Cytoplasm, Nucleus, Late endosome"], ["HGNC", "HGNC:9377"], ["HGNC symbol", "PRKAA2"], ["Previous symbols", "PRKAA"], ["Alias symbols", "AMPK, AMPKa2"], ["Entrez", "5563"], ["Ensembl", "ENSG00000162409"], ["RefSeq", "NM_006252"], ["UniProt", "P54646"], ["Note", "α2, dominant in muscle and heart"]]}] AMPKα PRKAG1; PRKAG2; PRKAG3 [{"symbol": "PRKAG1", "props": [["Full name", "5'-AMP-activated protein kinase subunit gamma-1"], ["Function", "AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation."], ["HGNC", "HGNC:9385"], ["HGNC symbol", "PRKAG1"], ["Entrez", "5571"], ["Ensembl", "ENSG00000181929"], ["RefSeq", "NM_002733"], ["UniProt", "P54619"], ["Note", "γ1, ubiquitous"]]}, {"symbol": "PRKAG2", "props": [["Full name", "5'-AMP-activated protein kinase subunit gamma-2"], ["Alternative names", "H91620p"], ["Function", "AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation."], ["HGNC", "HGNC:9386"], ["HGNC symbol", "PRKAG2"], ["Alias symbols", "AAKG, AAKG2, H91620p, WPWS, CMH6"], ["Entrez", "51422"], ["Ensembl", "ENSG00000106617"], ["RefSeq", "NM_016203"], ["UniProt", "Q9UGJ0"], ["Note", "γ2, high in heart"]]}, {"symbol": "PRKAG3", "props": [["Full name", "5'-AMP-activated protein kinase subunit gamma-3"], ["Function", "AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation."], ["HGNC", "HGNC:9387"], ["HGNC symbol", "PRKAG3"], ["Entrez", "53632"], ["Ensembl", "ENSG00000115592"], ["RefSeq", "NM_017431"], ["UniProt", "Q9UGI9"], ["Note", "γ3, skeletal muscle"]]}] AMPKγ CAB39; CAB39L [{"symbol": "CAB39", "props": [["Full name", "Calcium-binding protein 39"], ["Alternative names", "MO25alpha; Protein Mo25"], ["Function", "Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1"], ["Location", "Cytoplasm"], ["HGNC", "HGNC:20292"], ["HGNC symbol", "CAB39"], ["Alias symbols", "CGI-66, MO25"], ["Entrez", "51719"], ["Ensembl", "ENSG00000135932"], ["RefSeq", "NM_016289"], ["UniProt", "Q9Y376"], ["Note", "MO25α, ubiquitous"]]}, {"symbol": "CAB39L", "props": [["Full name", "Calcium-binding protein 39-like"], ["Alternative names", "Antigen MLAA-34; MO25beta; Mo25-like protein"], ["Function", "Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1"], ["HGNC", "HGNC:20290"], ["HGNC symbol", "CAB39L"], ["Alias symbols", "bA103J18.3, FLJ12577, MO2L, MLAA-34"], ["Entrez", "81617"], ["Ensembl", "ENSG00000102547"], ["RefSeq", "NM_030925"], ["UniProt", "Q9H9S4"], ["Note", "MO25β, broad expression"]]}] MO25 STRADA; STRADB [{"symbol": "STRADA", "props": [["Full name", "STE20-related kinase adapter protein alpha"], ["Alternative names", "STE20-related adapter protein; Serologically defined breast cancer antigen NY-BR-96"], ["Function", "Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation"], ["Location", "Nucleus, Cytoplasm"], ["HGNC", "HGNC:30172"], ["HGNC symbol", "STRADA"], ["Alias symbols", "STLK5, NY-BR-96, LYK5, Stlk, STRAD"], ["Entrez", "92335"], ["Ensembl", "ENSG00000266173"], ["RefSeq", "NM_001003786"], ["UniProt", "Q7RTN6"], ["Note", "STRADα, main LKB1 partner"]]}, {"symbol": "STRADB", "props": [["Full name", "STE20-related kinase adapter protein beta"], ["Alternative names", "Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein; CALS-21; ILP-interacting protein; Pseudokinase ALS2CR2"], ["Function", "Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation"], ["Location", "Nucleus, Cytoplasm"], ["HGNC", "HGNC:13205"], ["HGNC symbol", "STRADB"], ["Previous symbols", "ALS2CR2"], ["Alias symbols", "STLK6, CALS-21, PAPK, ILPIPA, ILPIP"], ["Entrez", "55437"], ["Ensembl", "ENSG00000082146"], ["RefSeq", "NM_018571"], ["UniProt", "Q9C0K7"], ["Note", "STRADβ, broad expression"]]}] STRAD Serine/threonine-protein kinase STK11 Liver kinase B1; Renal carcinoma antigen NY-REN-19 Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Nucleus, Cytoplasm, Membrane, Mitochondrion, Late endosome HGNC:11389 STK11 PJS, LKB1 6794 ENSG00000118046 NM_000455 Q15831 AMPK upstream kinase https://www.uniprot.org/uniprotkb/Q15831 P@S428 LKB1 STRADA; STRADB [{"symbol": "STRADA", "props": [["Full name", "STE20-related kinase adapter protein alpha"], ["Alternative names", "STE20-related adapter protein; Serologically defined breast cancer antigen NY-BR-96"], ["Function", "Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation"], ["Location", "Nucleus, Cytoplasm"], ["HGNC", "HGNC:30172"], ["HGNC symbol", "STRADA"], ["Alias symbols", "STLK5, NY-BR-96, LYK5, Stlk, STRAD"], ["Entrez", "92335"], ["Ensembl", "ENSG00000266173"], ["RefSeq", "NM_001003786"], ["UniProt", "Q7RTN6"], ["Note", "STRADα, main LKB1 partner"]]}, {"symbol": "STRADB", "props": [["Full name", "STE20-related kinase adapter protein beta"], ["Alternative names", "Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein; CALS-21; ILP-interacting protein; Pseudokinase ALS2CR2"], ["Function", "Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation"], ["Location", "Nucleus, Cytoplasm"], ["HGNC", "HGNC:13205"], ["HGNC symbol", "STRADB"], ["Previous symbols", "ALS2CR2"], ["Alias symbols", "STLK6, CALS-21, PAPK, ILPIPA, ILPIP"], ["Entrez", "55437"], ["Ensembl", "ENSG00000082146"], ["RefSeq", "NM_018571"], ["UniProt", "Q9C0K7"], ["Note", "STRADβ, broad expression"]]}] STRAD CAB39; CAB39L [{"symbol": "CAB39", "props": [["Full name", "Calcium-binding protein 39"], ["Alternative names", "MO25alpha; Protein Mo25"], ["Function", "Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1"], ["Location", "Cytoplasm"], ["HGNC", "HGNC:20292"], ["HGNC symbol", "CAB39"], ["Alias symbols", "CGI-66, MO25"], ["Entrez", "51719"], ["Ensembl", "ENSG00000135932"], ["RefSeq", "NM_016289"], ["UniProt", "Q9Y376"], ["Note", "MO25α, ubiquitous"]]}, {"symbol": "CAB39L", "props": [["Full name", "Calcium-binding protein 39-like"], ["Alternative names", "Antigen MLAA-34; MO25beta; Mo25-like protein"], ["Function", "Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1"], ["HGNC", "HGNC:20290"], ["HGNC symbol", "CAB39L"], ["Alias symbols", "bA103J18.3, FLJ12577, MO2L, MLAA-34"], ["Entrez", "81617"], ["Ensembl", "ENSG00000102547"], ["RefSeq", "NM_030925"], ["UniProt", "Q9H9S4"], ["Note", "MO25β, broad expression"]]}] MO25 MITOCHONDRION LABEL (R)-carnitine (-)-Carnitine; (-)-L-Carnitine; (3R)-3-hydroxy-4-(trimethylammonio)butanoate; 3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium hydroxide, inner salt; Carnicor; Carnitene; Carnitine; Carnitor; L-Carnitine; Levocarnitine; Vitamin BT The (R)-enantiomer of carnitine. C7H15NO3 CHEBI:16347 C00318 HMDB0000062 InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 PHIQHXFUZVPYII-ZCFIWIBFSA-N https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:16347 L-carnitine O-acyl-L-carnitine O-acyl-(R)-carnitine; O-acyl-(R)-carnitines; O-acyl-L-carnitines; an O-acyl-(R)-carnitine An O-acylcarnitine in which the carnitine component has L-configuration. C8H14NO4R CHEBI:75659 C02301 https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:75659 acyl-L-carnitine acyl-CoA(4-) an acyl-CoA An acyl-CoA oxoanion arising from deprotonation of the phosphate and diphosphate OH groups of any acyl-CoA; major species at pH 7.3. C22H31N7O17P3SR CHEBI:58342 https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:58342 acyl-CoA CPT1A; CPT1B [{"symbol": "CPT1A", "props": [["Full name", "Carnitine O-palmitoyltransferase 1, liver isoform"], ["Alternative names", "Carnitine O-palmitoyltransferase I, liver isoform; Carnitine palmitoyltransferase 1A; Succinyltransferase CPT1A"], ["Function", "Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Also possesses a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase activity."], ["Location", "Mitochondrion outer membrane"], ["HGNC", "HGNC:2328"], ["HGNC symbol", "CPT1A"], ["Previous symbols", "CPT1"], ["Alias symbols", "CPT1-L, L-CPT1"], ["Entrez", "1374"], ["Ensembl", "ENSG00000110090"], ["RefSeq", "NM_001876"], ["UniProt", "P50416"], ["Note", "Liver isoform"]]}, {"symbol": "CPT1B", "props": [["Full name", "Carnitine O-palmitoyltransferase 1, muscle isoform"], ["Alternative names", "Carnitine O-palmitoyltransferase I, muscle isoform; Carnitine palmitoyltransferase 1B; Carnitine palmitoyltransferase I-like protein"], ["Function", "Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion"], ["Location", "Mitochondrion outer membrane"], ["HGNC", "HGNC:2329"], ["HGNC symbol", "CPT1B"], ["Alias symbols", "M-CPT1, CPT1-M"], ["Entrez", "1375"], ["Ensembl", "ENSG00000205560"], ["RefSeq", "NM_152246"], ["UniProt", "Q92523"], ["Note", "Muscle and heart isoform"]]}] CPT1 Serine/threonine-protein kinase STK11 Liver kinase B1; Renal carcinoma antigen NY-REN-19 Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Nucleus, Cytoplasm, Membrane, Mitochondrion, Late endosome HGNC:11389 STK11 PJS, LKB1 6794 ENSG00000118046 NM_000455 Q15831 AMPK upstream kinase https://www.uniprot.org/uniprotkb/Q15831 P@S428 LKB1 CPT1A; CPT1B [{"symbol": "CPT1A", "props": [["Full name", "Carnitine O-palmitoyltransferase 1, liver isoform"], ["Alternative names", "Carnitine O-palmitoyltransferase I, liver isoform; Carnitine palmitoyltransferase 1A; Succinyltransferase CPT1A"], ["Function", "Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Also possesses a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase activity."], ["Location", "Mitochondrion outer membrane"], ["HGNC", "HGNC:2328"], ["HGNC symbol", "CPT1A"], ["Previous symbols", "CPT1"], ["Alias symbols", "CPT1-L, L-CPT1"], ["Entrez", "1374"], ["Ensembl", "ENSG00000110090"], ["RefSeq", "NM_001876"], ["UniProt", "P50416"], ["Note", "Liver isoform"]]}, {"symbol": "CPT1B", "props": [["Full name", "Carnitine O-palmitoyltransferase 1, muscle isoform"], ["Alternative names", "Carnitine O-palmitoyltransferase I, muscle isoform; Carnitine palmitoyltransferase 1B; Carnitine palmitoyltransferase I-like protein"], ["Function", "Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion"], ["Location", "Mitochondrion outer membrane"], ["HGNC", "HGNC:2329"], ["HGNC symbol", "CPT1B"], ["Alias symbols", "M-CPT1, CPT1-M"], ["Entrez", "1375"], ["Ensembl", "ENSG00000205560"], ["RefSeq", "NM_152246"], ["UniProt", "Q92523"], ["Note", "Muscle and heart isoform"]]}] CPT1 3',5'-cyclic AMP(1-) 3',5'-cyclic AMP anion; 3',5'-cyclic AMP; adenosine 3',5'-cyclic monophosphate anion; adenosine 3',5'-cyclic monophosphate; adenosine 3',5'-cyclic monophosphate(1-); adenosine 3',5'-phosphate An organophosphate oxoanion that is the conjugate base of 3',5'-cyclic AMP arising from deprotonation of the free phosphate OH group; major species at pH 7.3. C10H11N5O6P CHEBI:58165 InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 IVOMOUWHDPKRLL-KQYNXXCUSA-M https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:58165 cAMP PRKACA; PRKACB; PRKACG [{"symbol": "PRKACA", "props": [["Full name", "cAMP-dependent protein kinase catalytic subunit alpha"], ["Function", "Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, histone H1.4 (H1-4), PSMC5/RPT6, PJA2, RYR2, RORA, SLC6A6, SOX9, UHRF1 and VASP."], ["Location", "Cytoplasm, Cell membrane, Membrane, Nucleus, Mitochondrion, Cell projection, cilium, flagellum, Cytoplasmic vesicle, secretory vesicle, acrosome"], ["HGNC", "HGNC:9380"], ["HGNC symbol", "PRKACA"], ["Alias symbols", "PKACa"], ["Entrez", "5566"], ["Ensembl", "ENSG00000072062"], ["RefSeq", "NM_002730"], ["UniProt", "P17612"], ["Note", "Cα, ubiquitous"]]}, {"symbol": "PRKACB", "props": [["Full name", "cAMP-dependent protein kinase catalytic subunit beta"], ["Function", "Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux."], ["Location", "Cytoplasm, Cell membrane, Membrane, Nucleus"], ["HGNC", "HGNC:9381"], ["HGNC symbol", "PRKACB"], ["Alias symbols", "PKACb"], ["Entrez", "5567"], ["Ensembl", "ENSG00000142875"], ["RefSeq", "NM_182948"], ["UniProt", "P22694"], ["Note", "Cβ, ubiquitous, high in brain"]]}, {"symbol": "PRKACG", "props": [["Full name", "cAMP-dependent protein kinase catalytic subunit gamma"], ["Function", "Phosphorylates a large number of substrates in the cytoplasm and the nucleus"], ["HGNC", "HGNC:9382"], ["HGNC symbol", "PRKACG"], ["Alias symbols", "PKACg"], ["Entrez", "5568"], ["Ensembl", "ENSG00000165059"], ["RefSeq", "NM_002732"], ["UniProt", "P22612"], ["Note", "Cγ, testis"]]}] PKA-C LABEL PKA regulatory subunits PRKAR1A; PRKAR1B; PRKAR2A; PRKAR2B [{"symbol": "PRKAR1A", "props": [["Full name", "cAMP-dependent protein kinase type I-alpha regulatory subunit"], ["Alternative names", "Tissue-specific extinguisher 1"], ["Function", "Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells"], ["Location", "Cell membrane"], ["HGNC", "HGNC:9388"], ["HGNC symbol", "PRKAR1A"], ["Previous symbols", "PRKAR1, TSE1, PKR1, Prkar1alpha"], ["Alias symbols", "CNC1"], ["Entrez", "5573"], ["Ensembl", "ENSG00000108946"], ["RefSeq", "NM_001276289"], ["UniProt", "P10644"], ["Note", "RIα, ubiquitous"]]}, {"symbol": "PRKAR1B", "props": [["Full name", "cAMP-dependent protein kinase type I-beta regulatory subunit"], ["Function", "Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells"], ["Location", "Cell membrane"], ["HGNC", "HGNC:9390"], ["HGNC symbol", "PRKAR1B"], ["Entrez", "5575"], ["Ensembl", "ENSG00000188191"], ["RefSeq", "NM_001164758"], ["UniProt", "P31321"], ["Note", "RIβ, brain"]]}, {"symbol": "PRKAR2A", "props": [["Full name", "cAMP-dependent protein kinase type II-alpha regulatory subunit"], ["Function", "Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase"], ["Location", "Cytoplasm, Cell membrane"], ["HGNC", "HGNC:9391"], ["HGNC symbol", "PRKAR2A"], ["Previous symbols", "PRKAR2"], ["Entrez", "5576"], ["Ensembl", "ENSG00000114302"], ["RefSeq", "NM_001321982"], ["UniProt", "P13861"], ["Note", "RIIα, ubiquitous"]]}, {"symbol": "PRKAR2B", "props": [["Full name", "cAMP-dependent protein kinase type II-beta regulatory subunit"], ["Function", "Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase"], ["Location", "Cytoplasm, Cell membrane"], ["HGNC", "HGNC:9392"], ["HGNC symbol", "PRKAR2B"], ["Previous symbols", "PRKAR2"], ["Entrez", "5577"], ["Ensembl", "ENSG00000005249"], ["RefSeq", "NM_002736"], ["UniProt", "P31323"], ["Note", "RIIβ, brain and adipose tissue"]]}] PKA-R PRKACA; PRKACB; PRKACG [{"symbol": "PRKACA", "props": [["Full name", "cAMP-dependent protein kinase catalytic subunit alpha"], ["Function", "Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, histone H1.4 (H1-4), PSMC5/RPT6, PJA2, RYR2, RORA, SLC6A6, SOX9, UHRF1 and VASP."], ["Location", "Cytoplasm, Cell membrane, Membrane, Nucleus, Mitochondrion, Cell projection, cilium, flagellum, Cytoplasmic vesicle, secretory vesicle, acrosome"], ["HGNC", "HGNC:9380"], ["HGNC symbol", "PRKACA"], ["Alias symbols", "PKACa"], ["Entrez", "5566"], ["Ensembl", "ENSG00000072062"], ["RefSeq", "NM_002730"], ["UniProt", "P17612"], ["Note", "Cα, ubiquitous"]]}, {"symbol": "PRKACB", "props": [["Full name", "cAMP-dependent protein kinase catalytic subunit beta"], ["Function", "Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux."], ["Location", "Cytoplasm, Cell membrane, Membrane, Nucleus"], ["HGNC", "HGNC:9381"], ["HGNC symbol", "PRKACB"], ["Alias symbols", "PKACb"], ["Entrez", "5567"], ["Ensembl", "ENSG00000142875"], ["RefSeq", "NM_182948"], ["UniProt", "P22694"], ["Note", "Cβ, ubiquitous, high in brain"]]}, {"symbol": "PRKACG", "props": [["Full name", "cAMP-dependent protein kinase catalytic subunit gamma"], ["Function", "Phosphorylates a large number of substrates in the cytoplasm and the nucleus"], ["HGNC", "HGNC:9382"], ["HGNC symbol", "PRKACG"], ["Alias symbols", "PKACg"], ["Entrez", "5568"], ["Ensembl", "ENSG00000165059"], ["RefSeq", "NM_002732"], ["UniProt", "P22612"], ["Note", "Cγ, testis"]]}] PKA-C LABEL LABEL PKA regulatory subunits PRKAR1A; PRKAR1B; PRKAR2A; PRKAR2B [{"symbol": "PRKAR1A", "props": [["Full name", "cAMP-dependent protein kinase type I-alpha regulatory subunit"], ["Alternative names", "Tissue-specific extinguisher 1"], ["Function", "Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells"], ["Location", "Cell membrane"], ["HGNC", "HGNC:9388"], ["HGNC symbol", "PRKAR1A"], ["Previous symbols", "PRKAR1, TSE1, PKR1, Prkar1alpha"], ["Alias symbols", "CNC1"], ["Entrez", "5573"], ["Ensembl", "ENSG00000108946"], ["RefSeq", "NM_001276289"], ["UniProt", "P10644"], ["Note", "RIα, ubiquitous"]]}, {"symbol": "PRKAR1B", "props": [["Full name", "cAMP-dependent protein kinase type I-beta regulatory subunit"], ["Function", "Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells"], ["Location", "Cell membrane"], ["HGNC", "HGNC:9390"], ["HGNC symbol", "PRKAR1B"], ["Entrez", "5575"], ["Ensembl", "ENSG00000188191"], ["RefSeq", "NM_001164758"], ["UniProt", "P31321"], ["Note", "RIβ, brain"]]}, {"symbol": "PRKAR2A", "props": [["Full name", "cAMP-dependent protein kinase type II-alpha regulatory subunit"], ["Function", "Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase"], ["Location", "Cytoplasm, Cell membrane"], ["HGNC", "HGNC:9391"], ["HGNC symbol", "PRKAR2A"], ["Previous symbols", "PRKAR2"], ["Entrez", "5576"], ["Ensembl", "ENSG00000114302"], ["RefSeq", "NM_001321982"], ["UniProt", "P13861"], ["Note", "RIIα, ubiquitous"]]}, {"symbol": "PRKAR2B", "props": [["Full name", "cAMP-dependent protein kinase type II-beta regulatory subunit"], ["Function", "Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase"], ["Location", "Cytoplasm, Cell membrane"], ["HGNC", "HGNC:9392"], ["HGNC symbol", "PRKAR2B"], ["Previous symbols", "PRKAR2"], ["Entrez", "5577"], ["Ensembl", "ENSG00000005249"], ["RefSeq", "NM_002736"], ["UniProt", "P31323"], ["Note", "RIIβ, brain and adipose tissue"]]}] PKA-R 3',5'-cyclic AMP(1-) 3',5'-cyclic AMP anion; 3',5'-cyclic AMP; adenosine 3',5'-cyclic monophosphate anion; adenosine 3',5'-cyclic monophosphate; adenosine 3',5'-cyclic monophosphate(1-); adenosine 3',5'-phosphate An organophosphate oxoanion that is the conjugate base of 3',5'-cyclic AMP arising from deprotonation of the free phosphate OH group; major species at pH 7.3. C10H11N5O6P CHEBI:58165 InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 IVOMOUWHDPKRLL-KQYNXXCUSA-M https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:58165 cAMP PRKACA; PRKACB; PRKACG [{"symbol": "PRKACA", "props": [["Full name", "cAMP-dependent protein kinase catalytic subunit alpha"], ["Function", "Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, histone H1.4 (H1-4), PSMC5/RPT6, PJA2, RYR2, RORA, SLC6A6, SOX9, UHRF1 and VASP."], ["Location", "Cytoplasm, Cell membrane, Membrane, Nucleus, Mitochondrion, Cell projection, cilium, flagellum, Cytoplasmic vesicle, secretory vesicle, acrosome"], ["HGNC", "HGNC:9380"], ["HGNC symbol", "PRKACA"], ["Alias symbols", "PKACa"], ["Entrez", "5566"], ["Ensembl", "ENSG00000072062"], ["RefSeq", "NM_002730"], ["UniProt", "P17612"], ["Note", "Cα, ubiquitous"]]}, {"symbol": "PRKACB", "props": [["Full name", "cAMP-dependent protein kinase catalytic subunit beta"], ["Function", "Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux."], ["Location", "Cytoplasm, Cell membrane, Membrane, Nucleus"], ["HGNC", "HGNC:9381"], ["HGNC symbol", "PRKACB"], ["Alias symbols", "PKACb"], ["Entrez", "5567"], ["Ensembl", "ENSG00000142875"], ["RefSeq", "NM_182948"], ["UniProt", "P22694"], ["Note", "Cβ, ubiquitous, high in brain"]]}, {"symbol": "PRKACG", "props": [["Full name", "cAMP-dependent protein kinase catalytic subunit gamma"], ["Function", "Phosphorylates a large number of substrates in the cytoplasm and the nucleus"], ["HGNC", "HGNC:9382"], ["HGNC symbol", "PRKACG"], ["Alias symbols", "PKACg"], ["Entrez", "5568"], ["Ensembl", "ENSG00000165059"], ["RefSeq", "NM_002732"], ["UniProt", "P22612"], ["Note", "Cγ, testis"]]}] PKA-C LABEL PKA regulatory subunits PRKAR1A; PRKAR1B; PRKAR2A; PRKAR2B [{"symbol": "PRKAR1A", "props": [["Full name", "cAMP-dependent protein kinase type I-alpha regulatory subunit"], ["Alternative names", "Tissue-specific extinguisher 1"], ["Function", "Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells"], ["Location", "Cell membrane"], ["HGNC", "HGNC:9388"], ["HGNC symbol", "PRKAR1A"], ["Previous symbols", "PRKAR1, TSE1, PKR1, Prkar1alpha"], ["Alias symbols", "CNC1"], ["Entrez", "5573"], ["Ensembl", "ENSG00000108946"], ["RefSeq", "NM_001276289"], ["UniProt", "P10644"], ["Note", "RIα, ubiquitous"]]}, {"symbol": "PRKAR1B", "props": [["Full name", "cAMP-dependent protein kinase type I-beta regulatory subunit"], ["Function", "Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells"], ["Location", "Cell membrane"], ["HGNC", "HGNC:9390"], ["HGNC symbol", "PRKAR1B"], ["Entrez", "5575"], ["Ensembl", "ENSG00000188191"], ["RefSeq", "NM_001164758"], ["UniProt", "P31321"], ["Note", "RIβ, brain"]]}, {"symbol": "PRKAR2A", "props": [["Full name", "cAMP-dependent protein kinase type II-alpha regulatory subunit"], ["Function", "Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase"], ["Location", "Cytoplasm, Cell membrane"], ["HGNC", "HGNC:9391"], ["HGNC symbol", "PRKAR2A"], ["Previous symbols", "PRKAR2"], ["Entrez", "5576"], ["Ensembl", "ENSG00000114302"], ["RefSeq", "NM_001321982"], ["UniProt", "P13861"], ["Note", "RIIα, ubiquitous"]]}, {"symbol": "PRKAR2B", "props": [["Full name", "cAMP-dependent protein kinase type II-beta regulatory subunit"], ["Function", "Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase"], ["Location", "Cytoplasm, Cell membrane"], ["HGNC", "HGNC:9392"], ["HGNC symbol", "PRKAR2B"], ["Previous symbols", "PRKAR2"], ["Entrez", "5577"], ["Ensembl", "ENSG00000005249"], ["RefSeq", "NM_002736"], ["UniProt", "P31323"], ["Note", "RIIβ, brain and adipose tissue"]]}] PKA-R 3',5'-cyclic AMP(1-) 3',5'-cyclic AMP anion; 3',5'-cyclic AMP; adenosine 3',5'-cyclic monophosphate anion; adenosine 3',5'-cyclic monophosphate; adenosine 3',5'-cyclic monophosphate(1-); adenosine 3',5'-phosphate An organophosphate oxoanion that is the conjugate base of 3',5'-cyclic AMP arising from deprotonation of the free phosphate OH group; major species at pH 7.3. C10H11N5O6P CHEBI:58165 InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/p-1/t4-,6-,7-,10-/m1/s1 IVOMOUWHDPKRLL-KQYNXXCUSA-M https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:58165 cAMP adenosine 5'-monophosphate(2-) 5'-O-phosphonatoadenosine; AMP dianion; AMP; AMP(2-); Adenosine-5-monophosphate dianion; Adenosine-5-monophosphate(2-) A nucleoside 5'-monophosphate(2−) that results from the removal of two protons from the phosphate group of adenosine 5'-monophosphate (AMP). C10H12N5O7P CHEBI:456215 HMDB0000045 InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 UDMBCSSLTHHNCD-KQYNXXCUSA-L https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:456215 AMP P P P N:2 N:2 N:2 N:2 N:2