horizontal CYTOPLASM CYTOSOL horizontal CHEBI:16113 cholesterol horizontal CHEBI:30616 ATP horizontal CHEBI:33019 PPi horizontal horizontal PRKACA; PRKACB; PRKACG [{"symbol": "PRKACA", "props": [["HGNC", "HGNC:9380"], ["HGNC symbol", "PRKACA"], ["UniProt", "P17612"]]}, {"symbol": "PRKACB", "props": [["HGNC", "HGNC:9381"], ["HGNC symbol", "PRKACB"], ["UniProt", "P22694"]]}, {"symbol": "PRKACG", "props": [["HGNC", "HGNC:9382"], ["HGNC symbol", "PRKACG"], ["UniProt", "P22612"]]}] PKA-C horizontal PRKAR1A; PRKAR1B; PRKAR2A; PRKAR2B [{"symbol": "PRKAR1A", "props": [["HGNC", "HGNC:9388"], ["HGNC symbol", "PRKAR1A"], ["UniProt", "P10644"]]}, {"symbol": "PRKAR1B", "props": [["HGNC", "HGNC:9390"], ["HGNC symbol", "PRKAR1B"], ["UniProt", "P31321"]]}, {"symbol": "PRKAR2A", "props": [["HGNC", "HGNC:9391"], ["HGNC symbol", "PRKAR2A"], ["UniProt", "P13861"]]}, {"symbol": "PRKAR2B", "props": [["HGNC", "HGNC:9392"], ["HGNC symbol", "PRKAR2B"], ["UniProt", "P31323"]]}] PKA-R horizontal CHEBI:58165 cAMP horizontal horizontal PRKACA; PRKACB; PRKACG [{"symbol": "PRKACA", "props": [["HGNC", "HGNC:9380"], ["HGNC symbol", "PRKACA"], ["UniProt", "P17612"]]}, {"symbol": "PRKACB", "props": [["HGNC", "HGNC:9381"], ["HGNC symbol", "PRKACB"], ["UniProt", "P22694"]]}, {"symbol": "PRKACG", "props": [["HGNC", "HGNC:9382"], ["HGNC symbol", "PRKACG"], ["UniProt", "P22612"]]}] PKA-C horizontal PRKAR1A; PRKAR1B; PRKAR2A; PRKAR2B [{"symbol": "PRKAR1A", "props": [["HGNC", "HGNC:9388"], ["HGNC symbol", "PRKAR1A"], ["UniProt", "P10644"]]}, {"symbol": "PRKAR1B", "props": [["HGNC", "HGNC:9390"], ["HGNC symbol", "PRKAR1B"], ["UniProt", "P31321"]]}, {"symbol": "PRKAR2A", "props": [["HGNC", "HGNC:9391"], ["HGNC symbol", "PRKAR2A"], ["UniProt", "P13861"]]}, {"symbol": "PRKAR2B", "props": [["HGNC", "HGNC:9392"], ["HGNC symbol", "PRKAR2B"], ["UniProt", "P31323"]]}] PKA-R horizontal CHEBI:58165 cAMP horizontal HGNC:11359 STAR P49675 StAR horizontal horizontal HGNC:11359 STAR P49675 StAR horizontal PRKACA; PRKACB; PRKACG [{"symbol": "PRKACA", "props": [["HGNC", "HGNC:9380"], ["HGNC symbol", "PRKACA"], ["UniProt", "P17612"]]}, {"symbol": "PRKACB", "props": [["HGNC", "HGNC:9381"], ["HGNC symbol", "PRKACB"], ["UniProt", "P22694"]]}, {"symbol": "PRKACG", "props": [["HGNC", "HGNC:9382"], ["HGNC symbol", "PRKACG"], ["UniProt", "P22612"]]}] PKA-C horizontal PRKAR1A; PRKAR1B; PRKAR2A; PRKAR2B [{"symbol": "PRKAR1A", "props": [["HGNC", "HGNC:9388"], ["HGNC symbol", "PRKAR1A"], ["UniProt", "P10644"]]}, {"symbol": "PRKAR1B", "props": [["HGNC", "HGNC:9390"], ["HGNC symbol", "PRKAR1B"], ["UniProt", "P31321"]]}, {"symbol": "PRKAR2A", "props": [["HGNC", "HGNC:9391"], ["HGNC symbol", "PRKAR2A"], ["UniProt", "P13861"]]}, {"symbol": "PRKAR2B", "props": [["HGNC", "HGNC:9392"], ["HGNC symbol", "PRKAR2B"], ["UniProt", "P31323"]]}] PKA-R horizontal CHEBI:58165 cAMP vertical ? horizontal horizontal horizontal horizontal vertical horizontal MITOCHONDRIA Mitochondria horizontal CHEBI:16581 pregnenolone horizontal HGNC:2590 CYP11A1 P05108 P450scc horizontal CHEBI:16113 cholesterol horizontal horizontal NUCLEUS NUCLEUS horizontal HGNC:2345 CREB1 P16220 CREB horizontal HGNC:11359 STAR P49675 StAR horizontal horizontal HGNC:11359 STAR P49675 StAR horizontal PRKACA; PRKACB; PRKACG [{"symbol": "PRKACA", "props": [["HGNC", "HGNC:9380"], ["HGNC symbol", "PRKACA"], ["UniProt", "P17612"]]}, {"symbol": "PRKACB", "props": [["HGNC", "HGNC:9381"], ["HGNC symbol", "PRKACB"], ["UniProt", "P22694"]]}, {"symbol": "PRKACG", "props": [["HGNC", "HGNC:9382"], ["HGNC symbol", "PRKACG"], ["UniProt", "P22612"]]}] PKA-C horizontal CHEBI:30616 ATP horizontal CHEBI:456216 ADP horizontal HGNC:27301 CRTC2 Q53ET0 CRTC2 horizontal HGNC:2345 CREB1 P16220 P@S133 CREB horizontal horizontal HGNC:27301 CRTC2 Q53ET0 CRTC2 horizontal HGNC:2345 CREB1 P16220 P@S133 CREB vertical vertical horizontal vertical horizontal PLASMA MEMBRANE PLASMA MEMBRANE horizontal horizontal HGNC:4392 GNAS P63092 Gαs horizontal GNB1; GNB2; GNB3; GNB4 [{"symbol": "GNB1", "props": [["HGNC", "HGNC:4396"], ["HGNC symbol", "GNB1"], ["UniProt", "P62873"]]}, {"symbol": "GNB2", "props": [["HGNC", "HGNC:4398"], ["HGNC symbol", "GNB2"], ["UniProt", "P62879"]]}, {"symbol": "GNB3", "props": [["HGNC", "HGNC:4400"], ["HGNC symbol", "GNB3"], ["UniProt", "P16520"]]}, {"symbol": "GNB4", "props": [["HGNC", "HGNC:20731"], ["HGNC symbol", "GNB4"], ["UniProt", "Q9HAV0"]]}] Gβ horizontal GNG2; GNG3; GNG4; GNG5; GNG7; GNG8; GNG10; GNG11; GNG12; GNG13 [{"symbol": "GNG2", "props": [["HGNC", "HGNC:4404"], ["HGNC symbol", "GNG2"], ["UniProt", "P59768"]]}, {"symbol": "GNG3", "props": [["HGNC", "HGNC:4405"], ["HGNC symbol", "GNG3"], ["UniProt", "P63215"]]}, {"symbol": "GNG4", "props": [["HGNC", "HGNC:4407"], ["HGNC symbol", "GNG4"], ["UniProt", "P50150"]]}, {"symbol": "GNG5", "props": [["HGNC", "HGNC:4408"], ["HGNC symbol", "GNG5"], ["UniProt", "P63218"]]}, {"symbol": "GNG7", "props": [["HGNC", "HGNC:4410"], ["HGNC symbol", "GNG7"], ["UniProt", "O60262"]]}, {"symbol": "GNG8", "props": [["HGNC", "HGNC:19664"], ["HGNC symbol", "GNG8"], ["UniProt", "Q9UK08"]]}, {"symbol": "GNG10", "props": [["HGNC", "HGNC:4402"], ["HGNC symbol", "GNG10"], ["UniProt", "P50151"]]}, {"symbol": "GNG11", "props": [["HGNC", "HGNC:4403"], ["HGNC symbol", "GNG11"], ["UniProt", "P61952"]]}, {"symbol": "GNG12", "props": [["HGNC", "HGNC:19663"], ["HGNC symbol", "GNG12"], ["UniProt", "Q9UBI6"]]}, {"symbol": "GNG13", "props": [["HGNC", "HGNC:14131"], ["HGNC symbol", "GNG13"], ["UniProt", "Q9P2W3"]]}] Gγ horizontal HGNC:9594 PTGER2 P43116 EP2 horizontal ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY8; ADCY9 [{"symbol": "ADCY1", "props": [["HGNC", "HGNC:232"], ["HGNC symbol", "ADCY1"], ["UniProt", "Q08828"]]}, {"symbol": "ADCY2", "props": [["HGNC", "HGNC:233"], ["HGNC symbol", "ADCY2"], ["UniProt", "Q08462"]]}, {"symbol": "ADCY3", "props": [["HGNC", "HGNC:234"], ["HGNC symbol", "ADCY3"], ["UniProt", "O60266"]]}, {"symbol": "ADCY4", "props": [["HGNC", "HGNC:235"], ["HGNC symbol", "ADCY4"], ["UniProt", "Q8NFM4"]]}, {"symbol": "ADCY5", "props": [["HGNC", "HGNC:236"], ["HGNC symbol", "ADCY5"], ["UniProt", "O95622"]]}, {"symbol": "ADCY6", "props": [["HGNC", "HGNC:237"], ["HGNC symbol", "ADCY6"], ["UniProt", "O43306"]]}, {"symbol": "ADCY7", "props": [["HGNC", "HGNC:238"], ["HGNC symbol", "ADCY7"], ["UniProt", "P51828"]]}, {"symbol": "ADCY8", "props": [["HGNC", "HGNC:239"], ["HGNC symbol", "ADCY8"], ["UniProt", "P40145"]]}, {"symbol": "ADCY9", "props": [["HGNC", "HGNC:240"], ["HGNC symbol", "ADCY9"], ["UniProt", "O60503"]]}] ADCY horizontal ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY8; ADCY9 [{"symbol": "ADCY1", "props": [["HGNC", "HGNC:232"], ["HGNC symbol", "ADCY1"], ["UniProt", "Q08828"]]}, {"symbol": "ADCY2", "props": [["HGNC", "HGNC:233"], ["HGNC symbol", "ADCY2"], ["UniProt", "Q08462"]]}, {"symbol": "ADCY3", "props": [["HGNC", "HGNC:234"], ["HGNC symbol", "ADCY3"], ["UniProt", "O60266"]]}, {"symbol": "ADCY4", "props": [["HGNC", "HGNC:235"], ["HGNC symbol", "ADCY4"], ["UniProt", "Q8NFM4"]]}, {"symbol": "ADCY5", "props": [["HGNC", "HGNC:236"], ["HGNC symbol", "ADCY5"], ["UniProt", "O95622"]]}, {"symbol": "ADCY6", "props": [["HGNC", "HGNC:237"], ["HGNC symbol", "ADCY6"], ["UniProt", "O43306"]]}, {"symbol": "ADCY7", "props": [["HGNC", "HGNC:238"], ["HGNC symbol", "ADCY7"], ["UniProt", "P51828"]]}, {"symbol": "ADCY8", "props": [["HGNC", "HGNC:239"], ["HGNC symbol", "ADCY8"], ["UniProt", "P40145"]]}, {"symbol": "ADCY9", "props": [["HGNC", "HGNC:240"], ["HGNC symbol", "ADCY9"], ["UniProt", "O60503"]]}] ADCY horizontal horizontal HGNC:9594 PTGER2 P43116 EP2 horizontal CHEBI:606564 prostaglandin E2 horizontal horizontal HGNC:9594 PTGER2 P43116 EP2 horizontal CHEBI:606564 prostaglandin E2 horizontal HGNC:4392 GNAS P63092 Gαs horizontal GNB1; GNB2; GNB3; GNB4 [{"symbol": "GNB1", "props": [["HGNC", "HGNC:4396"], ["HGNC symbol", "GNB1"], ["UniProt", "P62873"]]}, {"symbol": "GNB2", "props": [["HGNC", "HGNC:4398"], ["HGNC symbol", "GNB2"], ["UniProt", "P62879"]]}, {"symbol": "GNB3", "props": [["HGNC", "HGNC:4400"], ["HGNC symbol", "GNB3"], ["UniProt", "P16520"]]}, {"symbol": "GNB4", "props": [["HGNC", "HGNC:20731"], ["HGNC symbol", "GNB4"], ["UniProt", "Q9HAV0"]]}] Gβ horizontal GNG2; GNG3; GNG4; GNG5; GNG7; GNG8; GNG10; GNG11; GNG12; GNG13 [{"symbol": "GNG2", "props": [["HGNC", "HGNC:4404"], ["HGNC symbol", "GNG2"], ["UniProt", "P59768"]]}, {"symbol": "GNG3", "props": [["HGNC", "HGNC:4405"], ["HGNC symbol", "GNG3"], ["UniProt", "P63215"]]}, {"symbol": "GNG4", "props": [["HGNC", "HGNC:4407"], ["HGNC symbol", "GNG4"], ["UniProt", "P50150"]]}, {"symbol": "GNG5", "props": [["HGNC", "HGNC:4408"], ["HGNC symbol", "GNG5"], ["UniProt", "P63218"]]}, {"symbol": "GNG7", "props": [["HGNC", "HGNC:4410"], ["HGNC symbol", "GNG7"], ["UniProt", "O60262"]]}, {"symbol": "GNG8", "props": [["HGNC", "HGNC:19664"], ["HGNC symbol", "GNG8"], ["UniProt", "Q9UK08"]]}, {"symbol": "GNG10", "props": [["HGNC", "HGNC:4402"], ["HGNC symbol", "GNG10"], ["UniProt", "P50151"]]}, {"symbol": "GNG11", "props": [["HGNC", "HGNC:4403"], ["HGNC symbol", "GNG11"], ["UniProt", "P61952"]]}, {"symbol": "GNG12", "props": [["HGNC", "HGNC:19663"], ["HGNC symbol", "GNG12"], ["UniProt", "Q9UBI6"]]}, {"symbol": "GNG13", "props": [["HGNC", "HGNC:14131"], ["HGNC symbol", "GNG13"], ["UniProt", "Q9P2W3"]]}] Gγ horizontal horizontal GNG2; GNG3; GNG4; GNG5; GNG7; GNG8; GNG10; GNG11; GNG12; GNG13 [{"symbol": "GNG2", "props": [["HGNC", "HGNC:4404"], ["HGNC symbol", "GNG2"], ["UniProt", "P59768"]]}, {"symbol": "GNG3", "props": [["HGNC", "HGNC:4405"], ["HGNC symbol", "GNG3"], ["UniProt", "P63215"]]}, {"symbol": "GNG4", "props": [["HGNC", "HGNC:4407"], ["HGNC symbol", "GNG4"], ["UniProt", "P50150"]]}, {"symbol": "GNG5", "props": [["HGNC", "HGNC:4408"], ["HGNC symbol", "GNG5"], ["UniProt", "P63218"]]}, {"symbol": "GNG7", "props": [["HGNC", "HGNC:4410"], ["HGNC symbol", "GNG7"], ["UniProt", "O60262"]]}, {"symbol": "GNG8", "props": [["HGNC", "HGNC:19664"], ["HGNC symbol", "GNG8"], ["UniProt", "Q9UK08"]]}, {"symbol": "GNG10", "props": [["HGNC", "HGNC:4402"], ["HGNC symbol", "GNG10"], ["UniProt", "P50151"]]}, {"symbol": "GNG11", "props": [["HGNC", "HGNC:4403"], ["HGNC symbol", "GNG11"], ["UniProt", "P61952"]]}, {"symbol": "GNG12", "props": [["HGNC", "HGNC:19663"], ["HGNC symbol", "GNG12"], ["UniProt", "Q9UBI6"]]}, {"symbol": "GNG13", "props": [["HGNC", "HGNC:14131"], ["HGNC symbol", "GNG13"], ["UniProt", "Q9P2W3"]]}] Gγ horizontal GNB1; GNB2; GNB3; GNB4 [{"symbol": "GNB1", "props": [["HGNC", "HGNC:4396"], ["HGNC symbol", "GNB1"], ["UniProt", "P62873"]]}, {"symbol": "GNB2", "props": [["HGNC", "HGNC:4398"], ["HGNC symbol", "GNB2"], ["UniProt", "P62879"]]}, {"symbol": "GNB3", "props": [["HGNC", "HGNC:4400"], ["HGNC symbol", "GNB3"], ["UniProt", "P16520"]]}, {"symbol": "GNB4", "props": [["HGNC", "HGNC:20731"], ["HGNC symbol", "GNB4"], ["UniProt", "Q9HAV0"]]}] Gβ horizontal HGNC:9594 PTGER2 P43116 EP2 horizontal CHEBI:606564 prostaglandin E2 horizontal HGNC:4392 GNAS P63092 Gαs horizontal vertical horizontal horizontal horizontal EXTRACELLULAR SPACE EXTRACELLULAR SPACE horizontal CHEBI:606564 prostaglandin E2 2 4 N:2 N:2 N:2 N:2 ct:mRNA N:2 ct:gene ct:mRNA P P inactive active