horizontal horizontal Glutaminase kidney isoform, mitochondrial K-glutaminase; L-glutamine amidohydrolase Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Mitochondrion, Cytoplasm, cytosol, Mitochondrion matrix HGNC:4331 GLS KIAA0838, GLS1, GAC, GAM, KGA 2744 ENSG00000115419 NM_001256310 O94925 Glutaminase C, GLS splice isoform horizontal https://www.uniprot.org/uniprotkb/O94925 GAC Protein kinase C epsilon type nPKC-epsilon Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Cytoplasm, Cytoplasm, cytoskeleton, Cell membrane, Cytoplasm, perinuclear region, Nucleus HGNC:9401 PRKCE PKCε 5581 ENSG00000171132 NM_005400 Q02156 Phosphorylates GAC https://www.uniprot.org/uniprotkb/Q02156 horizontal PKCε Protein kinase C epsilon type nPKC-epsilon Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Cytoplasm, Cytoplasm, cytoskeleton, Cell membrane, Cytoplasm, perinuclear region, Nucleus HGNC:9401 PRKCE PKCε 5581 ENSG00000171132 NM_005400 Q02156 Phosphorylates GAC https://www.uniprot.org/uniprotkb/Q02156 horizontal PKCε vertical Transcription factor p65 Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. Nucleus, Cytoplasm HGNC:9955 RELA p65, NFKB3 5970 ENSG00000173039 NM_021975 Q04206 p65 (RELA), binds the PRKCE promoter horizontal https://www.uniprot.org/uniprotkb/Q04206 NF-κB vertical Protein kinase C epsilon type nPKC-epsilon Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Cytoplasm, Cytoplasm, cytoskeleton, Cell membrane, Cytoplasm, perinuclear region, Nucleus HGNC:9401 PRKCE PKCε 5581 ENSG00000171132 NM_005400 Q02156 Phosphorylates GAC horizontal https://www.uniprot.org/uniprotkb/Q02156 PKCε L-glutamine zwitterion (2S)-5-amino-2-ammonio-5-oxopentanoate; (2S)-5-amino-2-azaniumyl-5-oxopentanoate; L-glutamine An amino acid zwitterion arising from transfer of a proton from the carboxy to the amino group of L-glutamine; major species at pH 7.3. C5H10N2O3 CHEBI:58359 InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine horizontal https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:58359 glutamine water BOUND WATER; H(2)O; H2O; HOH; Wasser; [OH2]; acqua; agua; aqua; dihydridooxygen; dihydrogen oxide; eau; hydrogen hydroxide; oxidane An oxygen hydride consisting of an oxygen atom that is covalently bonded to two hydrogen atoms H2O CHEBI:15377 C00001 HMDB0002111 InChI=1S/H2O/h1H2 XLYOFNOQVPJJNP-UHFFFAOYSA-N horizontal https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:15377 H2O L-glutamate(1-) (2S)-2-ammoniopentanedioate; L-glutamate; L-glutamic acid monoanion; L-glutamic acid, ion(1-); hydrogen L-glutamate An α-amino-acid anion that is the conjugate base of L-glutamic acid, having anionic carboxy groups and a cationic amino group C5H8NO4 CHEBI:29985 InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 WHUUTDBJXJRKMK-VKHMYHEASA-M horizontal https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:29985 glutamate ammonia Ammoniak; NH3; R-717; [NH3]; ammoniac; amoniaco; azane; spirit of hartshorn An azane that consists of a single nitrogen atom covelently bonded to three hydrogen atoms. H3N CHEBI:16134 C00014 HMDB0000051 InChI=1S/H3N/h1H3 QGZKDVFQNNGYKY-UHFFFAOYSA-N horizontal https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:16134 NH3 Glutaminase kidney isoform, mitochondrial K-glutaminase; L-glutamine amidohydrolase Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Mitochondrion, Cytoplasm, cytosol, Mitochondrion matrix HGNC:4331 GLS KIAA0838, GLS1, GAC, GAM, KGA 2744 ENSG00000115419 NM_001256310 O94925 Glutaminase C, GLS splice isoform horizontal https://www.uniprot.org/uniprotkb/O94925 GAC horizontal ATP(4-) ATP; adenosine 5'-triphosphate(4-) A nucleoside triphosphate(4−) obtained by global deprotonation of the triphosphate OH groups of ATP; major species present at pH 7.3. C10H12N5O13P3 CHEBI:30616 InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-4/t4-,6-,7-,10-/m1/s1 ZKHQWZAMYRWXGA-KQYNXXCUSA-J horizontal https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:30616 ATP horizontal ADP(3-) 5'-O-[(phosphonatooxy)phosphinato]adenosine; ADP trianion; ADP; adenosine 5'-diphosphate A nucleoside 5'-diphosphate(3−) arising from deprotonation of all three diphosphate OH groups of adenosine 5'-diphosphate (ADP); major species present at pH 7.3. C10H12N5O10P2 CHEBI:456216 InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 XTWYTFMLZFPYCI-KQYNXXCUSA-K horizontal https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:456216 ADP @S314 ct:gene ct:mRNA P@S314