horizontal MITOCHONDRION CYTOSOL horizontal L-glutamate(1-) (2S)-2-ammoniopentanedioate; L-glutamate; L-glutamic acid monoanion; L-glutamic acid, ion(1-); hydrogen L-glutamate An α-amino-acid anion that is the conjugate base of L-glutamic acid, having anionic carboxy groups and a cationic amino group C5H8NO4 CHEBI:29985 InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 WHUUTDBJXJRKMK-VKHMYHEASA-M https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:29985 glutamate horizontal acetyl-CoA(4-) 3'-phosphonatoadenosine 5'-(3-{(3R)-4-[(3-{[2-(acetylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl} diphosphate); AcCoA(4-); acetyl-CoA tetraanion; acetyl-CoA; acetyl-coenzyme A(4-) An acyl-CoA(4−) that is the tetraanion of acetyl-CoA, arising from deprotonation of the phosphate and diphosphate OH groups. C23H34N7O17P3S CHEBI:57288 InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 ZSLZBFCDCINBPY-ZSJPKINUSA-J https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:57288 acetyl-CoA vertical horizontal N-acetylglutamate synthase, mitochondrial Amino-acid acetyltransferase Plays a role in the regulation of ureagenesis by producing the essential cofactor N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPS1) activity Mitochondrion matrix HGNC:17996 NAGS AGAS, ARGA, NAT7 162417 ENSG00000161653 NM_153006 Q8N159 https://www.uniprot.org/uniprotkb/Q8N159 NAGS horizontal coenzyme A(4-) 3'-phosphonatoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl] diphosphate}; CoA Tetraanion of coenzyme A. C21H32N7O16P3S CHEBI:57287 InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 RGJOEKWQDUBAIZ-IBOSZNHHSA-J https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:57287 CoA horizontal N-acetyl-L-glutamate(2-) (2S)-2-acetamidopentanedioate; (S)-2-(acetylamino)pentanedioate; N-Acetyl-L-glutamate; NAG; acetyl-L-glutamate An N-acyl-L-α-amino acid anion resulting from deprotonation of both carboxy groups of N-acetyl-L-glutamic acid. C7H9NO5 CHEBI:44337 C00624 HMDB0001138 InChI=1S/C7H11NO5/c1-4(9)8-5(7(12)13)2-3-6(10)11/h5H,2-3H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-2/t5-/m0/s1 RFMMMVDNIPUKGG-YFKPBYRVSA-L Obligate CPS1 activator https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:44337 N-acetylglutamate horizontal ammonium Ammonium(1+); NH(4)(+); NH4(+); NH4+; [NH4](+); ammonium cation; ammonium ion; azanium An onium cation obtained by protonation of ammonia. H4N CHEBI:28938 C01342 InChI=1S/H3N/h1H3/p+1 QGZKDVFQNNGYKY-UHFFFAOYSA-O https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28938 NH4+ horizontal ATP(4-) ATP; adenosine 5'-triphosphate(4-) A nucleoside triphosphate(4−) obtained by global deprotonation of the triphosphate OH groups of ATP; major species present at pH 7.3. C10H12N5O13P3 CHEBI:30616 InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-4/t4-,6-,7-,10-/m1/s1 ZKHQWZAMYRWXGA-KQYNXXCUSA-J https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:30616 ATP horizontal hydrogencarbonate Acid carbonate; BICARBONATE ION; Bicarbonate; HCO3(-); HCO3-; [CO2(OH)](-); hydrogen carbonate; hydrogen(trioxidocarbonate)(1-); hydrogencarbonate(1-); hydrogentrioxocarbonate(1-); hydrogentrioxocarbonate(IV); hydroxidodioxidocarbonate(1-) The carbon oxoanion resulting from the removal of a proton from carbonic acid. CHO3 CHEBI:17544 C00288 HMDB0000595 InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-1 BVKZGUZCCUSVTD-UHFFFAOYSA-M https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:17544 HCO3- vertical horizontal Carbamoyl-phosphate synthase [ammonia], mitochondrial Carbamoyl-phosphate synthetase I Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell Mitochondrion, Nucleus, nucleolus, Cell membrane HGNC:2323 CPS1 GATD6 1373 ENSG00000021826 NM_001122633 P31327 https://www.uniprot.org/uniprotkb/P31327 CPS1 horizontal Carbamoyl-phosphate synthase [ammonia], mitochondrial Carbamoyl-phosphate synthetase I Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell Mitochondrion, Nucleus, nucleolus, Cell membrane HGNC:2323 CPS1 GATD6 1373 ENSG00000021826 NM_001122633 P31327 https://www.uniprot.org/uniprotkb/P31327 CPS1 vertical horizontal NAD-dependent protein deacylase sirtuin-5, mitochondrial Regulatory protein SIR2 homolog 5; SIR2-like protein 5 NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Mitochondrion matrix, Mitochondrion intermembrane space, Cytoplasm, cytosol, Nucleus, Cytoplasm, Mitochondrion HGNC:14933 SIRT5 23408 ENSG00000124523 NM_001193267 Q9NXA8 Desuccinylates and deglutarylates CPS1, activating it https://www.uniprot.org/uniprotkb/Q9NXA8 SIRT5 horizontal ADP(3-) 5'-O-[(phosphonatooxy)phosphinato]adenosine; ADP trianion; ADP; adenosine 5'-diphosphate A nucleoside 5'-diphosphate(3−) arising from deprotonation of all three diphosphate OH groups of adenosine 5'-diphosphate (ADP); major species present at pH 7.3. C10H12N5O10P2 CHEBI:456216 InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 XTWYTFMLZFPYCI-KQYNXXCUSA-K https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:456216 ADP horizontal hydrogenphosphate HPO4(2-); HYDROGENPHOSPHATE ION; INORGANIC PHOSPHATE GROUP; [P(OH)O3](2-); [PO3(OH)](2-); hydrogen phosphate; hydrogen(tetraoxidophosphate)(2-); hydrogentetraoxophosphate(2-); hydrogentetraoxophosphate(V); hydroxidotrioxidophosphate(2-); phosphate A phosphate ion that is the conjugate base of dihydrogenphosphate. HO4P CHEBI:43474 InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 NBIIXXVUZAFLBC-UHFFFAOYSA-L https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:43474 Pi horizontal carbamoyl phosphate(2-) carbamoyl phosphate dianion; carbamoyl phosphate A doubly-charged organophosphate oxoanion arising from deprotonation of the phosphate OH groups of carbamoyl phosphate; major species at pH 7.3. CH2NO5P CHEBI:58228 InChI=1S/CH4NO5P/c2-1(3)7-8(4,5)6/h(H2,2,3)(H2,4,5,6)/p-2 FFQKYPRQEYGKAF-UHFFFAOYSA-L https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:58228 carbamoyl-P horizontal L-ornithinium(1+) (2S)-2,5-diammoniopentanoate; L-ornithine monocation; L-ornithine; L-ornithinium A polar amino acid zwitterion of L-ornithine. C5H13N2O2 CHEBI:46911 InChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)/p+1/t4-/m0/s1 AHLPHDHHMVZTML-BYPYZUCNSA-O https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:46911 ornithine vertical horizontal Ornithine transcarbamylase, mitochondrial Ornithine carbamoyltransferase, mitochondrial Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline. The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion Mitochondrion matrix HGNC:8512 OTC OTCase, OTCD, OTC1 5009 ENSG00000036473 NM_000531 P00480 https://www.uniprot.org/uniprotkb/P00480 OTC horizontal hydrogenphosphate HPO4(2-); HYDROGENPHOSPHATE ION; INORGANIC PHOSPHATE GROUP; [P(OH)O3](2-); [PO3(OH)](2-); hydrogen phosphate; hydrogen(tetraoxidophosphate)(2-); hydrogentetraoxophosphate(2-); hydrogentetraoxophosphate(V); hydroxidotrioxidophosphate(2-); phosphate A phosphate ion that is the conjugate base of dihydrogenphosphate. HO4P CHEBI:43474 InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 NBIIXXVUZAFLBC-UHFFFAOYSA-L https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:43474 Pi horizontal L-citrulline zwitterion (2S)-2-azaniumyl-5-(carbamoylamino)pentanoate; L-citrulline Zwitterionic form of L-citrulline having an anionic carboxy group and a protonated amino group; major species at pH 7.3. C6H13N3O3 CHEBI:57743 InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 RHGKLRLOHDJJDR-BYPYZUCNSA-N https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:57743 citrulline vertical horizontal N-acetyl-L-glutamate(2-) (2S)-2-acetamidopentanedioate; (S)-2-(acetylamino)pentanedioate; N-Acetyl-L-glutamate; NAG; acetyl-L-glutamate An N-acyl-L-α-amino acid anion resulting from deprotonation of both carboxy groups of N-acetyl-L-glutamic acid. C7H9NO5 CHEBI:44337 C00624 HMDB0001138 InChI=1S/C7H11NO5/c1-4(9)8-5(7(12)13)2-3-6(10)11/h5H,2-3H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-2/t5-/m0/s1 RFMMMVDNIPUKGG-YFKPBYRVSA-L Obligate CPS1 activator https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:44337 N-acetylglutamate horizontal Carbamoyl-phosphate synthase [ammonia], mitochondrial Carbamoyl-phosphate synthetase I Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell Mitochondrion, Nucleus, nucleolus, Cell membrane HGNC:2323 CPS1 GATD6 1373 ENSG00000021826 NM_001122633 P31327 https://www.uniprot.org/uniprotkb/P31327 CPS1 horizontal Carbamoyl-phosphate synthase [ammonia], mitochondrial Carbamoyl-phosphate synthetase I Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell Mitochondrion, Nucleus, nucleolus, Cell membrane HGNC:2323 CPS1 GATD6 1373 ENSG00000021826 NM_001122633 P31327 https://www.uniprot.org/uniprotkb/P31327 CPS1 vertical horizontal L-argininium(1+) (2S)-2-amino-5-(carbamimidamido)pentanoate; (2S)-2-amino-5-guanidinopentanoate; (2S)-2-ammonio-5-guanidiniopentanoate; (2S)-2-azaniumyl-5-{[azaniumyl(imino)methyl]amino}pentanoate; L-arginine cation; L-arginine monocation; L-arginine; L-argininium; arginine(1+) The L-enantiomer of argininium(1+). C6H15N4O2 CHEBI:32682 InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 ODKSFYDXXFIFQN-BYPYZUCNSA-O https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:32682 arginine vertical horizontal Mitochondrial ornithine transporter 1 Solute carrier family 25 member 15 Mitochondrial ornithine-citrulline antiporter (Probable). Catalyzes the exchange between cytosolic ornithine and mitochondrial citrulline plus an H(+), the proton compensates the positive charge of ornithine thus leading to an electroneutral transport. Mitochondrion inner membrane, Mitochondrion membrane HGNC:10985 SLC25A15 ORC1, lnc-HC, D13S327, ORNT1, HHH 10166 ENSG00000102743 NM_014252 Q9Y619 Mitochondrial ornithine/citrulline carrier https://www.uniprot.org/uniprotkb/Q9Y619 SLC25A15 vertical horizontal L-citrulline zwitterion (2S)-2-azaniumyl-5-(carbamoylamino)pentanoate; L-citrulline Zwitterionic form of L-citrulline having an anionic carboxy group and a protonated amino group; major species at pH 7.3. C6H13N3O3 CHEBI:57743 InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 RHGKLRLOHDJJDR-BYPYZUCNSA-N https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:57743 citrulline horizontal L-aspartate(1-) (2S)-2-ammoniobutanedioate; (2S)-2-ammoniosuccinate; L-aspartate; L-aspartic acid monoanion; hydrogen L-aspartate An aspartate(1−) that is the conjugate base of L-aspartic acid. C4H6NO4 CHEBI:29991 InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 CKLJMWTZIZZHCS-REOHCLBHSA-M https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:29991 aspartate horizontal ATP(4-) ATP; adenosine 5'-triphosphate(4-) A nucleoside triphosphate(4−) obtained by global deprotonation of the triphosphate OH groups of ATP; major species present at pH 7.3. C10H12N5O13P3 CHEBI:30616 InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-4/t4-,6-,7-,10-/m1/s1 ZKHQWZAMYRWXGA-KQYNXXCUSA-J https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:30616 ATP vertical horizontal adenosine 5'-monophosphate(2-) 5'-O-phosphonatoadenosine; AMP dianion; AMP; AMP(2-); Adenosine-5-monophosphate dianion; Adenosine-5-monophosphate(2-) A nucleoside 5'-monophosphate(2−) that results from the removal of two protons from the phosphate group of adenosine 5'-monophosphate (AMP). C10H12N5O7P CHEBI:456215 HMDB0000045 InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 UDMBCSSLTHHNCD-KQYNXXCUSA-L https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:456215 AMP horizontal diphosphate(3-) HP2O7(3-); diphosphate; hydrogen diphosphate A trivalent inorganic anion obtained by removal of all three protons from diphosphoric acid. HO7P2 CHEBI:33019 InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 XPPKVPWEQAFLFU-UHFFFAOYSA-K https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:33019 PPi horizontal (N(omega)-L-arginino)succinate(1-) 2-(N(omega)-L-arginino)succinate; 2-{[{[(4S)-4-ammonio-4-carboxylatobutyl]amino}(iminio)methyl]amino}succinate; 2-{[{[(4S)-4-azaniumyl-4-carboxylatobutyl]amino}(iminiumyl)methyl]amino}butanedioate Conjugate base of (Nω-L-arginino)succinic acid. C10H17N4O6 CHEBI:57472 InChI=1S/C10H18N4O6/c11-5(8(17)18)2-1-3-13-10(12)14-6(9(19)20)4-7(15)16/h5-6H,1-4,11H2,(H,15,16)(H,17,18)(H,19,20)(H3,12,13,14)/p-1/t5-,6?/m0/s1 KDZOASGQNOPSCU-ZBHICJROSA-M https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:57472 argininosuccinate vertical horizontal Argininosuccinate lyase Arginosuccinase Catalyzes the reversible cleavage of L-argininosuccinate to fumarate and L-arginine, an intermediate step reaction in the urea cycle mostly providing for hepatic nitrogen detoxification into excretable urea as well as de novo L-arginine synthesis in nonhepatic tissues. Essential regulator of intracellular and extracellular L-arginine pools. HGNC:746 ASL ASAL 435 ENSG00000126522 NM_000048 P04424 https://www.uniprot.org/uniprotkb/P04424 ASL horizontal fumarate(2-) (2E)-but-2-enedioate; (E)-2-butenedioic acid, ion(2-); FUMARATE A C4-dicarboxylate that is the E-isomer of but-2-enedioate(2−) C4H2O4 CHEBI:29806 C00122 InChI=1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/p-2/b2-1+ VZCYOOQTPOCHFL-OWOJBTEDSA-L https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:29806 fumarate horizontal L-argininium(1+) (2S)-2-amino-5-(carbamimidamido)pentanoate; (2S)-2-amino-5-guanidinopentanoate; (2S)-2-ammonio-5-guanidiniopentanoate; (2S)-2-azaniumyl-5-{[azaniumyl(imino)methyl]amino}pentanoate; L-arginine cation; L-arginine monocation; L-arginine; L-argininium; arginine(1+) The L-enantiomer of argininium(1+). C6H15N4O2 CHEBI:32682 InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 ODKSFYDXXFIFQN-BYPYZUCNSA-O https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:32682 arginine vertical horizontal Arginase-1 Liver-type arginase; Type I arginase Catalyzes the final step of the urea cycle by hydrolyzing L-arginine into urea, a nitrogenous waste product, and L-ornithine, a precursor to proline and polyamines; the urea cycle occurs primarily in the liver and, to a lesser extent, in the kidneys Cytoplasm, cytosol, Cytoplasmic granule HGNC:663 ARG1 383 ENSG00000118520 NM_000045 P05089 https://www.uniprot.org/uniprotkb/P05089 ARG1 horizontal urea 1728; Carbamide; E927b; H2NC(O)NH2; Harnstoff; Karbamid; carbonyldiamide; ur; uree A carbonyl group with two C-bound amine groups. The commercially available fertilizer has an analysis of 46-0-0 (N-P2O5-K2O). CH4N2O CHEBI:16199 C00086 HMDB0000294 InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4) XSQUKJJJFZCRTK-UHFFFAOYSA-N https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:16199 urea horizontal L-ornithinium(1+) (2S)-2,5-diammoniopentanoate; L-ornithine monocation; L-ornithine; L-ornithinium A polar amino acid zwitterion of L-ornithine. C5H13N2O2 CHEBI:46911 InChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)/p+1/t4-/m0/s1 AHLPHDHHMVZTML-BYPYZUCNSA-O https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:46911 ornithine horizontal Argininosuccinate synthase Citrulline--aspartate ligase One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues Cytoplasm, cytosol HGNC:758 ASS1 CTLN1, ASS 445 ENSG00000130707 NM_000050 P00966 https://www.uniprot.org/uniprotkb/P00966 ASS1 Su Glut