CYTOPLASM LABEL glucose glucose PYGM PYGM GYS1 GYS1 PHKG1 LABEL PHKA1 Calmodulin PHKB PHKG1 LABEL PHKA1 Calmodulin PHKB Ca2+ PKA cat LABEL PHKA1 PHKB Calmodulin PHKG1 LABEL PHKA1 Calmodulin PHKB PHKG1 α-D-glucose-1P UDP-D-glucose UTP Pi PPP1 UGP2 PDK GSK3B GSK3B IRS PI3K LABEL PI3K IRS1 IRS AKT1 cAMP ATP PPi PLASMA MEMBRANE LABEL PI(4,5)P2 PI(3,4,5)P3 INSR LABEL INSR INS LABEL IRS P INSR INS LABEL PI(3,4,5)P3 PDK LABEL PI(3,4,5)P3 AKT1 LABEL PI(3,4,5)P3 AKT1 GCGR LABEL GCGR GCG ADCY LABEL LABEL GNB GNG LABEL GNA GDP LABEL GTP GNA LABEL GNB GNG GTP GDP LABEL ADCY LABEL GNA GTP LABEL PKA reg N:2 PKA cat N:2 LABEL PKA cat N:2 LABEL PKA reg N:2 cAMP cAMP LABEL PKA reg N:2 cAMP cAMP EXTRACELLULAR SPACE LABEL INS GCG N:n glycogen glycogen N:n+1 N:2 P N:4 P P Ca2+ P active Ca2+ P Ca2+ P P P P P P P