</head><body>[-:-] Invalid element id [-:-] Invalid element id [-:-] Invalid element id [-:-] Invalid element id [-:-] Invalid element id [-:-] Invalid element id [-:-] Invalid element id [-:-] Invalid element id [-:-] Invalid element id [-:-] Invalid element id [-:-] Invalid element id [-:-] Invalid element id [-:-] Invalid element id [-:-] Invalid element id [-:-] Invalid element id [-:-] Invalid element id [-:-] Invalid element id [-:-] Invalid element id [-:-] Invalid element id [-:-] Invalid element id [-:-] Invalid element id [-:-] Invalid element id [-:-] Invalid element id [-:-] Invalid element id</body></html></notes><annotation> <celldesigner:extension> <celldesigner:modelVersion>4.0</celldesigner:modelVersion> <celldesigner:modelDisplay sizeX="1000" sizeY="800"/> <celldesigner:listOfIncludedSpecies> <celldesigner:species id="s_id_n3__n0" name="PKA_space_reg"><celldesigner:notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title/></head><body> <rdf:RDF 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</celldesigner:listOfSpeciesAliases> <celldesigner:listOfProteins><celldesigner:protein id="p_0" name="PKA_space_reg" type="GENERIC"> </celldesigner:protein> <celldesigner:protein id="p_1" name="F1,6BP" type="GENERIC"> </celldesigner:protein> <celldesigner:protein id="p_2" name="PFK1" type="GENERIC"> </celldesigner:protein> <celldesigner:protein id="p_3" name="PFKFB2" type="GENERIC"> <celldesigner:listOfModificationResidues><celldesigner:modificationResidue id="mr_re_1_1" angle="5.160172548656537"></celldesigner:modificationResidue></celldesigner:listOfModificationResidues> </celldesigner:protein> <celldesigner:protein id="p_4" name="ADCY" type="GENERIC"> </celldesigner:protein> <celldesigner:protein id="p_5" name="PKA_space_cat" type="GENERIC"> </celldesigner:protein> <celldesigner:protein id="p_6" name="GPI" type="GENERIC"> </celldesigner:protein> </celldesigner:listOfProteins> <celldesigner:listOfGenes></celldesigner:listOfGenes> <celldesigner:listOfRNAs></celldesigner:listOfRNAs> <celldesigner:listOfAntisenseRNAs></celldesigner:listOfAntisenseRNAs> <celldesigner:listOfLayers></celldesigner:listOfLayers> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#F001_glycolysis"> <dcterms:modified rdf:parseType="Resource"></dcterms:modified> </rdf:Description> </rdf:RDF> </annotation> <listOfCompartments> <compartment metaid="default" id="default" name="default" size="1" units="volume" > <notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title/></head><body> </body></html></notes> <annotation> <celldesigner:extension> <celldesigner:name>default</celldesigner:name> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#default"> <dcterms:modified rdf:parseType="Resource"></dcterms:modified> </rdf:Description> </rdf:RDF> </annotation> </compartment> </listOfCompartments> <listOfSpecies><species name="cAMP" id="s_id_n0" metaid="s_id_n0" initialConcentration="0.0" hasOnlySubstanceUnits="false" constant="false" boundaryCondition="false" compartment="default"><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title/></head><body>Name: 3',5'-cyclic AMP Synonyms: 3', 5'-Cyclic AMP, ADENOSINE-3', 5'-CYCLIC-MONOPHOSPHATE, Adenosine 3', 5'-cyclic phosphate, Adenosine 3', 5'-phosphate, Cyclic AMP, Cyclic adenylic acid, adenosine 3', 5'-cyclic monophosphate, cAMP </body></html></notes> <annotation><celldesigner:extension><celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment><celldesigner:speciesIdentity><celldesigner:class>SIMPLE_MOLECULE</celldesigner:class> <celldesigner:name>cAMP</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s_id_n0"> <bqmodel:is> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:inchikey:IVOMOUWHDPKRLL-KQYNXXCUSA-N"/> </rdf:Bag> </bqmodel:is> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:obo.chebi:CHEBI%3A17489"/> </rdf:Bag> </bqbiol:isDescribedBy> <bqmodel:is> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:inchi:InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1"/> </rdf:Bag> </bqmodel:is> <dcterms:modified rdf:parseType="Resource"></dcterms:modified> </rdf:Description> </rdf:RDF> </annotation> </species> <species name="PKA_space_reg" id="s_id_n1" metaid="s_id_n1" initialConcentration="0.0" hasOnlySubstanceUnits="false" constant="false" boundaryCondition="false" compartment="default"><annotation><celldesigner:extension><celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment><celldesigner:speciesIdentity><celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>p_0</celldesigner:proteinReference> <celldesigner:state> <celldesigner:homodimer>2</celldesigner:homodimer> <celldesigner:listOfStructuralStates> <celldesigner:structuralState structuralState="cAMP">cAMP</celldesigner:structuralState></celldesigner:listOfStructuralStates> </celldesigner:state> <celldesigner:name>PKA_space_reg</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s_id_n1"> <dcterms:modified rdf:parseType="Resource"></dcterms:modified> </rdf:Description> </rdf:RDF> </annotation> </species> <species name="_beta__minus_D_minus_fructose_minus_1,6P2" id="s_id_n13" metaid="s_id_n13" initialConcentration="0.0" hasOnlySubstanceUnits="false" constant="false" boundaryCondition="false" compartment="default"><annotation><celldesigner:extension><celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment><celldesigner:speciesIdentity><celldesigner:class>SIMPLE_MOLECULE</celldesigner:class> <celldesigner:name>_beta__minus_D_minus_fructose_minus_1,6P2</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s_id_n13"> <dcterms:modified rdf:parseType="Resource"></dcterms:modified> </rdf:Description> </rdf:RDF> </annotation> </species> <species name="F1,6BP" id="s_id_n14" metaid="s_id_n14" initialConcentration="0.0" hasOnlySubstanceUnits="false" constant="false" boundaryCondition="false" compartment="default"><annotation><celldesigner:extension><celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment><celldesigner:speciesIdentity><celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>p_1</celldesigner:proteinReference> <celldesigner:name>F1,6BP</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s_id_n14"> <dcterms:modified rdf:parseType="Resource"></dcterms:modified> </rdf:Description> </rdf:RDF> </annotation> </species> <species name="PFK1" id="s_id_n15" metaid="s_id_n15" initialConcentration="0.0" hasOnlySubstanceUnits="false" constant="false" boundaryCondition="false" compartment="default"><annotation><celldesigner:extension><celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment><celldesigner:speciesIdentity><celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>p_2</celldesigner:proteinReference> <celldesigner:name>PFK1</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s_id_n15"> <dcterms:modified rdf:parseType="Resource"></dcterms:modified> </rdf:Description> </rdf:RDF> </annotation> </species> <species name="_beta__minus_D_minus_fructose_minus_2,6P2" id="s_id_n16" metaid="s_id_n16" initialConcentration="0.0" hasOnlySubstanceUnits="false" constant="false" boundaryCondition="false" compartment="default"><annotation><celldesigner:extension><celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment><celldesigner:speciesIdentity><celldesigner:class>SIMPLE_MOLECULE</celldesigner:class> <celldesigner:name>_beta__minus_D_minus_fructose_minus_2,6P2</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s_id_n16"> <dcterms:modified rdf:parseType="Resource"></dcterms:modified> </rdf:Description> </rdf:RDF> </annotation> </species> <species name="PFKFB2" id="s_id_n19" metaid="s_id_n19" initialAmount="0.0" hasOnlySubstanceUnits="false" constant="false" boundaryCondition="false" compartment="default"><annotation><celldesigner:extension><celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment><celldesigner:speciesIdentity><celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>p_3</celldesigner:proteinReference> <celldesigner:state> <celldesigner:listOfModifications> <celldesigner:modification residue="mr_re_1_1" state="phosphorylated"> </celldesigner:modification> </celldesigner:listOfModifications> </celldesigner:state> <celldesigner:name>PFKFB2</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s_id_n19"> <dcterms:modified rdf:parseType="Resource"></dcterms:modified> </rdf:Description> </rdf:RDF> </annotation> </species> <species name="PFKFB2" id="s_id_n21" metaid="s_id_n21" initialConcentration="0.0" hasOnlySubstanceUnits="false" constant="false" boundaryCondition="false" compartment="default"><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title/></head><body>Symbol: PFKFB2 Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 HGNC_ID: 8873 EntrezGene_ID: 5208 RefSeq_ID: NM_001018053 </body></html></notes> <annotation><celldesigner:extension><celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment><celldesigner:speciesIdentity><celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>p_3</celldesigner:proteinReference> <celldesigner:state> <celldesigner:listOfModifications> </celldesigner:listOfModifications> </celldesigner:state> <celldesigner:name>PFKFB2</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s_id_n21"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:refseq:NM_001018053"/> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:ensembl:ENSG00000123836"/> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:hgnc:8873"/> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:ncbigene:5208"/> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:uniprot:O60825"/> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:hgnc.symbol:PFKFB2"/> </rdf:Bag> </bqbiol:isDescribedBy> <dcterms:modified rdf:parseType="Resource"></dcterms:modified> </rdf:Description> </rdf:RDF> </annotation> </species> <species name="ATP" id="s_id_n22" metaid="s_id_n22" initialConcentration="0.0" hasOnlySubstanceUnits="false" constant="false" boundaryCondition="false" compartment="default"><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title/></head><body>Name: ATP Synonyms: ADENOSINE-5'-TRIPHOSPHATE, ATP, Adenosine 5'-triphosphate, Adenosine triphosphate, Adephos, Adetol, Adynol, Atipi, Atriphos, Cardenosine, Fosfobion, Glucobasin, H4atp, Myotriphos, Triadenyl, Triphosphaden </body></html></notes> <annotation><celldesigner:extension><celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment><celldesigner:speciesIdentity><celldesigner:class>SIMPLE_MOLECULE</celldesigner:class> <celldesigner:name>ATP</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s_id_n22"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:obo.chebi:CHEBI%3A15422"/> </rdf:Bag> </bqbiol:isDescribedBy> <bqmodel:is> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:inchikey:ZKHQWZAMYRWXGA-KQYNXXCUSA-N"/> </rdf:Bag> </bqmodel:is> <bqmodel:is> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:inchi:InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1"/> </rdf:Bag> </bqmodel:is> <dcterms:modified rdf:parseType="Resource"></dcterms:modified> </rdf:Description> </rdf:RDF> </annotation> </species> <species name="ADCY" id="s_id_n24" metaid="s_id_n24" initialConcentration="0.0" hasOnlySubstanceUnits="false" constant="false" boundaryCondition="false" compartment="default"><annotation><celldesigner:extension><celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment><celldesigner:speciesIdentity><celldesigner:class>PROTEIN</celldesigner:class> <celldesigner:proteinReference>p_4</celldesigner:proteinReference> <celldesigner:name>ADCY</celldesigner:name> </celldesigner:speciesIdentity> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s_id_n24"> <dcterms:modified rdf:parseType="Resource"></dcterms:modified> </rdf:Description> </rdf:RDF> </annotation> </species> <species name="" id="s_id_n3" metaid="s_id_n3" initialConcentration="0.0" hasOnlySubstanceUnits="false" constant="false" boundaryCondition="false" compartment="default"><annotation><celldesigner:extension><celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment><celldesigner:speciesIdentity><celldesigner:class>COMPLEX</celldesigner:class> </celldesigner:speciesIdentity> </celldesigner:extension> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/"> <rdf:Description rdf:about="#s_id_n3"> <dcterms:modified rdf:parseType="Resource"></dcterms:modified> </rdf:Description> 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