3',5'-cyclic AMP

PKA regulatory Subunit binded to two cAMP

Tetramer composed by two catalytic and two regulatory subunits

PKA regulatory subunit

PKA catalytic subunit

PKA tetramer, consisting in two catalytic and two regulatory subunits

PKA catalytic subunit

a-D-glucose 6-phosphate

b-D-fructose 6-phosphate

Glucose-6-phosphate isomerase

AKA:b- D-fructofuranose 1,6-bisphosphate

Fructose-1,6-bisphosphatase

ATP-dependent 6-phosphofructokinase

b-D-fructofuranose 2,6-bisphosphate

fructose-2,6-bisphosphatase

6-phosphofructo-2-kinase phosphorilated at serine 36

ATP

Adenylate cyclase

diphosphate ion

cAMP-dependent protein kinase regulatory subunit

PKA catalytic subunit

2

4