CYTOPLASM

glucose

glucose

glycogen phosphorylase

glycogen phosphorylase

Glycogen synthase

Glycogen synthase

Phosphorylase b kinase gamma catalytic chain

Phosphorylase b kinase regulatory subunit alpha

Calmodulin

Phosphorylase b kinase regulatory subunit beta

Phosphorylase b kinase gamma catalytic chain

Phosphorylase b kinase regulatory subunit alpha

Calmodulin

Phosphorylase b kinase regulatory subunit beta

Ca2+

protein kinase A catalytic subunit

Phosphorylase b kinase regulatory subunit alpha

Phosphorylase b kinase regulatory subunit beta

Calmodulin

Phosphorylase b kinase gamma catalytic chain

Phosphorylase b kinase regulatory subunit alpha

Calmodulin

Phosphorylase b kinase regulatory subunit beta

Phosphorylase b kinase gamma catalytic chain

?-D-glucose-1P

UDP-D-glucose

uridine triphosphate

inorganic phosphate

Protein
phosphatase 1

UDP-glucose pyrophosphorylase 2

3-phosphoinositide-dependent protein kinase 1

Glycogen synthase kinase-3 beta

Glycogen synthase kinase-3 beta

phosphorylated insulin receptor substrate 1

Phosphatidylinositol 3-kinase regulatory subunit

Phosphatidylinositol 3-kinase regulatory subunit

phosphorylated insulin receptor substrate 1

insulin receptor substrate 1

RAC-alpha serine/threonine-protein kinase

PLASMA MEMBRANE

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate

Insulin receptor

phosphorylated insulin receptor

insulin

insulin receptor substrate 1

phosphorylated insulin receptor

insulin

1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate

3-phosphoinositide-dependent protein kinase 1

1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate

phosphorylated RAC-alpha serine/threonine-protein kinase

1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate

phosphorylated RAC-alpha serine/threonine-protein kinase

EXTRACELLULAR SPACE

insulin