Sec23

Sec24

Endoplasmic Reticulum

Sterol

Insulin-induced gene 1 protein

SCAP

INSIG1/2

Sterol

SREBP2

SCAP-SREBP2 complex

SREBP cleavage-activating protein

sterol regulatory element-binding proteins

SCAP

Sec23

Sec24

Sar1

SREBP2

GTP-binding protein SAR1a

Protein coat complex

Protein transport protein SEC23

rotein transport protein Sec24

Sar1

COPII-coated vesicle

Golgi

SREBP2

SREBP2

Membrane-bound transcription factor site-1 protease

Membrane bound transcription factor site-2 protease

SCAP

SREBP2

SCAP

Nucleus

SREBP2

Transcription
of target genes

Importin-?

Cholesterol
biosynthesis

SCAP

Sec23

Sec24

Sar1

SREBP2