Sec23
Sec24
Endoplasmic Reticulum
Sterol
Insulin-induced gene 1 protein
SCAP
INSIG1/2
Sterol
SREBP2
SCAP-SREBP2 complex
SREBP cleavage-activating protein
sterol regulatory element-binding proteins
SCAP
Sec23
Sec24
Sar1
SREBP2
GTP-binding protein SAR1a
Protein coat complex
Protein transport protein SEC23
rotein transport protein Sec24
Sar1
COPII-coated vesicle
Golgi
SREBP2
SREBP2
Membrane-bound transcription factor site-1 protease
Membrane bound transcription factor site-2 protease
SCAP
SREBP2
SCAP
Nucleus
SREBP2
Transcription
of target genes
Importin-?
Cholesterol
biosynthesis
SCAP
Sec23
Sec24
Sar1
SREBP2