CYTOSOL

Interferon regulatory factor 1

fumarate

aspartate

citrulline

O2

arginine

nitric oxide

Inducible nitric oxide synthase mRNA

Interferon regulatory factor 1 mRNA

arginino-succcinate

STAT bisphosphorilated

Signal transducer and activator of transcription 1-alpha

STAT1 phosphorilated dimer

Nitric oxide synthase, inducible

Calmodulin

CaM

iNOS

Argininosuccinate lyase tetramer

Argininosuccinate synthase

NUCLEUS

Signal transducer and activator of transcription 1-alpha

Interferon regulatory factor 1 mRNA

Interferon regulatory factor 1 mRNA

Inducible nitric oxide synthase mRNA

Inducible nitric oxide synthase gene

Interferon regulatory factor 1

PLASMA MEMBRANE

Tyrosine-protein kinase JAK1

Tyrosine-protein kinase JAK2

Interferon gamma Receptor 2

Interferon gamma Receptor 1

iNTERFERON GAMMA DIMER

IFN?R2

Tyrosine-protein kinase JAK1

Tyrosine-protein kinase JAK2

Interferon gamma Receptor 1

Interferon gamma dimer

Interferon gamma Receptor 1

Interferon Gamma RECEPTOR 2

Tyrosine-protein kinase JAK1

Tyrosine-protein kinase JAK2

EXTRACELLULAR SPACE

Interferon gamma dimer

arginine

nitric oxide

AND

AND

2

2

2