CYTOPLASM

cholesterol

ATP

pyrophosphate

protein kinase A catalytic subunit

protein kinase A regulatory subunit

cAMP

protein kinase A catalytic subunit

protein kinase A regualtory subunit

Steroidogenic acute regulatory protein

Steroidogenic acute regulatory protein

protein kinase A catalytic subunit

protein kinase A regulatory subunit

?

MITOCHONDRIA

pregnenolone

cholesterol side-chain cleavage enzyme

cholesterol

NUCLEUS

cyclic-AMP responsive element-binding protein

Steroidogenic acute regulatory protein

Steroidogenic acute regulatory protein

protein kinase A catalytic subunit

ATP

ADP

CREB-regulated transcription coactivator 2

cyclic-AMP responsive-element binding protein

CREB-regulated transcription coactivator 2

cyclic-AMP responsive-element binding protein

PLASMA MEMBRANE

Gs?

Gs?

Gs?

EP2

adenylate cyclase

adenylate cyclase

EP2

prostaglanine E2

EP2

prostaglanine E2

Gs?

Gs?

Gs?

Gs?

Gs?

EP2

prostaglanine E2

Gs?

EXTRACELLULAR SPACE

prostaglanine E2

2

4