<?xml version="1.0" encoding="UTF-8" standalone="no"?>
<graphml xmlns="http://graphml.graphdrawing.org/xmlns" xmlns:java="http://www.yworks.com/xml/yfiles-common/1.0/java" xmlns:sys="http://www.yworks.com/xml/yfiles-common/markup/primitives/2.0" xmlns:x="http://www.yworks.com/xml/yfiles-common/markup/2.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:y="http://www.yworks.com/xml/graphml" xmlns:yed="http://www.yworks.com/xml/yed/3" xsi:schemaLocation="http://graphml.graphdrawing.org/xmlns http://www.yworks.com/xml/schema/graphml/1.1/ygraphml.xsd">
  <!--Created by yEd 3.18.0.2-->
  <key attr.name="Description" attr.type="string" for="graph" id="d0"/>
  <key for="port" id="d1" yfiles.type="portgraphics"/>
  <key for="port" id="d2" yfiles.type="portgeometry"/>
  <key for="port" id="d3" yfiles.type="portuserdata"/>
  <key attr.name="url" attr.type="string" for="node" id="d4"/>
  <key attr.name="description" attr.type="string" for="node" id="d5"/>
  <key for="node" id="d6" yfiles.type="nodegraphics"/>
  <key for="graphml" id="d7" yfiles.type="resources"/>
  <key attr.name="url" attr.type="string" for="edge" id="d8"/>
  <key attr.name="description" attr.type="string" for="edge" id="d9"/>
  <key for="edge" id="d10" yfiles.type="edgegraphics"/>
  <graph edgedefault="directed" id="G">
    <data key="d0"/>
    <node id="n0">
      <data key="d6">
        <y:GenericNode configuration="com.yworks.sbgn.SimpleChemical">
          <y:Geometry height="32.0" width="60.0" x="-233.38994579450332" y="-1277.8977169914597"/>
          <y:Fill color="#E4EAC4" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="40.626953125" x="9.6865234375" y="5.755859375">cAMP<y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
        </y:GenericNode>
      </data>
    </node>
    <node id="n1">
      <data key="d6">
        <y:GenericNode configuration="com.yworks.sbgn.Macromolecule">
          <y:Geometry height="40.0" width="80.0" x="-38.38994579450332" y="-1009.2463575468996"/>
          <y:Fill color="#C2D4ED" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="57.224609375" x="11.3876953125" y="9.755859375">PKA reg<y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
          <y:NodeLabel alignment="center" autoSizePolicy="content" backgroundColor="#FFFFFF" bottomInset="2" fontFamily="Dialog" fontSize="10" fontStyle="plain" height="15.77734375" horizontalTextPosition="center" iconTextGap="4" leftInset="4" lineColor="#000000" modelName="custom" rightInset="4" textColor="#000000" topInset="2" verticalTextPosition="center" visible="true" width="24.875" x="27.5625" y="-7.888671875">N:2<y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="-0.5" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
          <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="0.0" bottomInset="0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="18.0" horizontalTextPosition="center" iconData="1" iconTextGap="0" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="40.0" x="-3.1271063246098976" y="30.6798692111322">
            <y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="-0.42182234188475254" labelRatioY="0.01778504382598889" nodeRatioX="-0.5" nodeRatioY="0.5" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
          <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="0.0" bottomInset="0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="18.0" horizontalTextPosition="center" iconData="2" iconTextGap="0" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="40.0" x="43.17026946967809" y="30.6798692111322">
            <y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.4207432632580478" labelRatioY="0.01778504382598889" nodeRatioX="0.5" nodeRatioY="0.5" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
          <y:StyleProperties>
            <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radius" value="10"/>
            <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.mcount" value="2"/>
          </y:StyleProperties>
        </y:GenericNode>
      </data>
    </node>
    <node id="n2">
      <data key="d6">
        <y:GenericNode configuration="com.yworks.sbgn.Process">
          <y:Geometry height="18.0" width="18.0" x="-93.04870136708445" y="-1241.9598131669024"/>
          <y:Fill color="#FFFFFF" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" bottomInset="0" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="0.0" horizontalTextPosition="center" iconTextGap="4" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="0.0" x="9.0" y="9.0">
            <y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
        </y:GenericNode>
      </data>
    </node>
    <node id="n3" yfiles.foldertype="group">
      <data key="d6">
        <y:ProxyAutoBoundsNode>
          <y:Realizers active="0">
            <y:GenericGroupNode configuration="com.yworks.sbgn.Complex">
              <y:Geometry height="144.77095734126976" width="106.0" x="-134.04870136708445" y="-1428.8181631031453"/>
              <y:Fill color="#F2F4F8" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="8.0" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="4.0" horizontalTextPosition="center" iconTextGap="4" modelName="internal" modelPosition="t" textColor="#000000" verticalTextPosition="bottom" visible="true" width="4.0" x="51.0" y="8.0"/>
              <y:StyleProperties>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusY" value="12"/>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusX" value="12"/>
              </y:StyleProperties>
              <y:State autoResize="true" closed="false" closedHeight="80.0" closedWidth="80.0"/>
              <y:Insets bottom="15" bottomF="15.0" left="10" leftF="10.0" right="10" rightF="10.0" top="10" topF="10.0"/>
              <y:BorderInsets bottom="0" bottomF="0.0" left="0" leftF="0.0" right="0" rightF="0.0" top="2" topF="2.0102436046923913"/>
            </y:GenericGroupNode>
            <y:GenericGroupNode configuration="com.yworks.sbgn.Complex">
              <y:Geometry height="80.0" width="80.0" x="553.2728174603176" y="-237.95622840696382"/>
              <y:Fill color="#FFFFFF" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="8.0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="18.1328125" horizontalTextPosition="center" iconTextGap="4" modelName="internal" modelPosition="t" textColor="#000000" verticalTextPosition="bottom" visible="true" width="38.482421875" x="20.7587890625" y="8.0">LABEL</y:NodeLabel>
              <y:StyleProperties>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusY" value="12"/>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusX" value="12"/>
              </y:StyleProperties>
              <y:State autoResize="true" closed="true" closedHeight="80.0" closedWidth="80.0"/>
              <y:Insets bottom="15" bottomF="15.0" left="10" leftF="10.0" right="10" rightF="10.0" top="10" topF="10.0"/>
              <y:BorderInsets bottom="0" bottomF="0.0" left="0" leftF="0.0" right="0" rightF="0.0" top="0" topF="0.0"/>
            </y:GenericGroupNode>
          </y:Realizers>
        </y:ProxyAutoBoundsNode>
      </data>
      <graph edgedefault="directed" id="n3:">
        <node id="n3::n0">
          <data key="d6">
            <y:GenericNode configuration="com.yworks.sbgn.Macromolecule">
              <y:Geometry height="40.0" width="80.0" x="-124.04870136708445" y="-1404.919247623453"/>
              <y:Fill color="#C2D4ED" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="57.224609375" x="11.3876953125" y="9.755859375">PKA reg<y:LabelModel>
                  <y:SmartNodeLabelModel distance="4.0"/>
                </y:LabelModel>
                <y:ModelParameter>
                  <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
                </y:ModelParameter>
              </y:NodeLabel>
              <y:NodeLabel alignment="center" autoSizePolicy="content" backgroundColor="#FFFFFF" bottomInset="2" fontFamily="Dialog" fontSize="10" fontStyle="plain" height="15.77734375" horizontalTextPosition="center" iconTextGap="4" leftInset="4" lineColor="#000000" modelName="custom" rightInset="4" textColor="#000000" topInset="2" verticalTextPosition="center" visible="true" width="24.875" x="27.5625" y="-7.888671875">N:2<y:LabelModel>
                  <y:SmartNodeLabelModel distance="4.0"/>
                </y:LabelModel>
                <y:ModelParameter>
                  <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="-0.5" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
                </y:ModelParameter>
              </y:NodeLabel>
              <y:StyleProperties>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radius" value="10"/>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.mcount" value="2"/>
              </y:StyleProperties>
            </y:GenericNode>
          </data>
        </node>
        <node id="n3::n1">
          <data key="d6">
            <y:GenericNode configuration="com.yworks.sbgn.Macromolecule">
              <y:Geometry height="40.0" width="80.0" x="-124.04870136708445" y="-1345.0472057618756"/>
              <y:Fill color="#C2D4ED" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="55.10546875" x="12.447265625" y="9.755859375">PKA cat<y:LabelModel>
                  <y:SmartNodeLabelModel distance="4.0"/>
                </y:LabelModel>
                <y:ModelParameter>
                  <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
                </y:ModelParameter>
              </y:NodeLabel>
              <y:NodeLabel alignment="center" autoSizePolicy="content" backgroundColor="#FFFFFF" bottomInset="2" fontFamily="Dialog" fontSize="10" fontStyle="plain" height="15.77734375" horizontalTextPosition="center" iconTextGap="4" leftInset="4" lineColor="#000000" modelName="custom" rightInset="4" textColor="#000000" topInset="2" verticalTextPosition="center" visible="true" width="24.875" x="27.5625" y="-7.888671875">N:2<y:LabelModel>
                  <y:SmartNodeLabelModel distance="4.0"/>
                </y:LabelModel>
                <y:ModelParameter>
                  <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="-0.5" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
                </y:ModelParameter>
              </y:NodeLabel>
              <y:StyleProperties>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radius" value="10"/>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.mcount" value="2"/>
              </y:StyleProperties>
            </y:GenericNode>
          </data>
        </node>
      </graph>
    </node>
    <node id="n4">
      <data key="d6">
        <y:GenericNode configuration="com.yworks.sbgn.Process">
          <y:Geometry height="18.0" width="18.0" x="-93.04870136708445" y="-1022.4044358560132"/>
          <y:Fill color="#FFFFFF" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" bottomInset="0" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="0.0" horizontalTextPosition="center" iconTextGap="4" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="0.0" x="9.0" y="9.0">
            <y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
        </y:GenericNode>
      </data>
    </node>
    <node id="n5" yfiles.foldertype="group">
      <data key="d6">
        <y:ProxyAutoBoundsNode>
          <y:Realizers active="0">
            <y:GenericGroupNode configuration="com.yworks.sbgn.Complex">
              <y:Geometry height="145.62910819772083" width="109.1271063246099" x="-137.17580769169433" y="-1198.033544053734"/>
              <y:Fill color="#F2F4F8" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="8.0" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="4.0" horizontalTextPosition="center" iconTextGap="4" modelName="internal" modelPosition="t" textColor="#000000" verticalTextPosition="bottom" visible="true" width="4.0" x="52.56355316230494" y="8.0"/>
              <y:StyleProperties>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusY" value="12"/>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusX" value="12"/>
              </y:StyleProperties>
              <y:State autoResize="true" closed="false" closedHeight="80.0" closedWidth="80.0"/>
              <y:Insets bottom="15" bottomF="15.0" left="10" leftF="10.0" right="10" rightF="10.0" top="10" topF="10.0"/>
              <y:BorderInsets bottom="0" bottomF="0.0" left="0" leftF="0.0" right="0" rightF="0.0" top="2" topF="1.7121746218940643"/>
            </y:GenericGroupNode>
            <y:GenericGroupNode configuration="com.yworks.sbgn.Complex">
              <y:Geometry height="80.0" width="80.0" x="553.2728174603176" y="-237.95622840696382"/>
              <y:Fill color="#FFFFFF" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="8.0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="18.1328125" horizontalTextPosition="center" iconTextGap="4" modelName="internal" modelPosition="t" textColor="#000000" verticalTextPosition="bottom" visible="true" width="38.482421875" x="20.7587890625" y="8.0">LABEL</y:NodeLabel>
              <y:StyleProperties>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusY" value="12"/>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radiusX" value="12"/>
              </y:StyleProperties>
              <y:State autoResize="true" closed="true" closedHeight="80.0" closedWidth="80.0"/>
              <y:Insets bottom="15" bottomF="15.0" left="10" leftF="10.0" right="10" rightF="10.0" top="10" topF="10.0"/>
              <y:BorderInsets bottom="0" bottomF="0.0" left="0" leftF="0.0" right="0" rightF="0.0" top="0" topF="0.0"/>
            </y:GenericGroupNode>
          </y:Realizers>
        </y:ProxyAutoBoundsNode>
      </data>
      <graph edgedefault="directed" id="n5:">
        <node id="n5::n0">
          <data key="d6">
            <y:GenericNode configuration="com.yworks.sbgn.Macromolecule">
              <y:Geometry height="40.0" width="80.0" x="-124.04870136708445" y="-1113.4044358560132"/>
              <y:Fill color="#C2D4ED" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="55.10546875" x="12.447265625" y="9.755859375">PKA cat<y:LabelModel>
                  <y:SmartNodeLabelModel distance="4.0"/>
                </y:LabelModel>
                <y:ModelParameter>
                  <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
                </y:ModelParameter>
              </y:NodeLabel>
              <y:NodeLabel alignment="center" autoSizePolicy="content" backgroundColor="#FFFFFF" bottomInset="2" fontFamily="Dialog" fontSize="10" fontStyle="plain" height="15.77734375" horizontalTextPosition="center" iconTextGap="4" leftInset="4" lineColor="#000000" modelName="custom" rightInset="4" textColor="#000000" topInset="2" verticalTextPosition="center" visible="true" width="24.875" x="27.5625" y="-7.888671875">N:2<y:LabelModel>
                  <y:SmartNodeLabelModel distance="4.0"/>
                </y:LabelModel>
                <y:ModelParameter>
                  <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="-0.5" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
                </y:ModelParameter>
              </y:NodeLabel>
              <y:StyleProperties>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radius" value="10"/>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.mcount" value="2"/>
              </y:StyleProperties>
            </y:GenericNode>
          </data>
        </node>
        <node id="n5::n1">
          <data key="d6">
            <y:GenericNode configuration="com.yworks.sbgn.Macromolecule">
              <y:Geometry height="40.0" width="80.0" x="-124.04870136708445" y="-1174.43269755684"/>
              <y:Fill color="#C2D4ED" transparent="false"/>
              <y:BorderStyle color="#000000" type="line" width="1.0"/>
              <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="57.224609375" x="11.3876953125" y="9.755859375">PKA reg<y:LabelModel>
                  <y:SmartNodeLabelModel distance="4.0"/>
                </y:LabelModel>
                <y:ModelParameter>
                  <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
                </y:ModelParameter>
              </y:NodeLabel>
              <y:NodeLabel alignment="center" autoSizePolicy="content" backgroundColor="#FFFFFF" bottomInset="2" fontFamily="Dialog" fontSize="10" fontStyle="plain" height="15.77734375" horizontalTextPosition="center" iconTextGap="4" leftInset="4" lineColor="#000000" modelName="custom" rightInset="4" textColor="#000000" topInset="2" verticalTextPosition="center" visible="true" width="24.875" x="27.5625" y="-7.888671875">N:2<y:LabelModel>
                  <y:SmartNodeLabelModel distance="4.0"/>
                </y:LabelModel>
                <y:ModelParameter>
                  <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="-0.5" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
                </y:ModelParameter>
              </y:NodeLabel>
              <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="0.0" bottomInset="0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="18.0" horizontalTextPosition="center" iconData="1" iconTextGap="0" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="40.0" x="-3.1271063246098976" y="30.6798692111322">
                <y:LabelModel>
                  <y:SmartNodeLabelModel distance="4.0"/>
                </y:LabelModel>
                <y:ModelParameter>
                  <y:SmartNodeLabelModelParameter labelRatioX="-0.42182234188475254" labelRatioY="0.01778504382598889" nodeRatioX="-0.5" nodeRatioY="0.5" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
                </y:ModelParameter>
              </y:NodeLabel>
              <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="0.0" bottomInset="0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="18.0" horizontalTextPosition="center" iconData="2" iconTextGap="0" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="40.0" x="43.17026946967809" y="30.6798692111322">
                <y:LabelModel>
                  <y:SmartNodeLabelModel distance="4.0"/>
                </y:LabelModel>
                <y:ModelParameter>
                  <y:SmartNodeLabelModelParameter labelRatioX="0.4207432632580478" labelRatioY="0.01778504382598889" nodeRatioX="0.5" nodeRatioY="0.5" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
                </y:ModelParameter>
              </y:NodeLabel>
              <y:StyleProperties>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radius" value="10"/>
                <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.mcount" value="2"/>
              </y:StyleProperties>
            </y:GenericNode>
          </data>
        </node>
      </graph>
    </node>
    <node id="n6">
      <data key="d6">
        <y:GenericNode configuration="com.yworks.sbgn.Macromolecule">
          <y:Geometry height="40.0" width="80.0" x="-125.38994579450332" y="-944.2463575468996"/>
          <y:Fill color="#C2D4ED" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Arial" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="19.640625" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="54.5791015625" x="12.71044921875" y="10.1796875">PKA cat<y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
          <y:StyleProperties>
            <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radius" value="10"/>
          </y:StyleProperties>
        </y:GenericNode>
      </data>
    </node>
    <node id="n7">
      <data key="d6">
        <y:GenericNode configuration="com.yworks.sbgn.SimpleChemical">
          <y:Geometry height="32.0" width="140.0" x="-713.1218344204844" y="-1070.2463575468996"/>
          <y:Fill color="#E4EAC4" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Arial" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="19.640625" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="101.5693359375" x="19.21533203125" y="6.1796875">α-D-glucose-6P<y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
        </y:GenericNode>
      </data>
    </node>
    <node id="n8">
      <data key="d6">
        <y:GenericNode configuration="com.yworks.sbgn.SimpleChemical">
          <y:Geometry height="32.0" width="140.0" x="-713.1218344204844" y="-940.2463575468996"/>
          <y:Fill color="#E4EAC4" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Arial" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="19.640625" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="103.0732421875" x="18.46337890625" y="6.1796875">β-D-fructose-6P<y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
        </y:GenericNode>
      </data>
    </node>
    <node id="n9">
      <data key="d6">
        <y:GenericNode configuration="com.yworks.sbgn.Macromolecule">
          <y:Geometry height="40.0" width="80.0" x="-788.1218344204844" y="-1009.2463575468996"/>
          <y:Fill color="#C2D4ED" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Arial" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="19.640625" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="28.1171875" x="25.94140625" y="10.1796875">GPI<y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
          <y:StyleProperties>
            <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radius" value="10"/>
          </y:StyleProperties>
        </y:GenericNode>
      </data>
    </node>
    <node id="n10">
      <data key="d6">
        <y:GenericNode configuration="com.yworks.sbgn.Process">
          <y:Geometry height="18.0" width="18.0" x="-652.1218344204844" y="-998.2463575468996"/>
          <y:Fill color="#FFFFFF" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" bottomInset="0" fontFamily="Arial" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="0.0" horizontalTextPosition="center" iconTextGap="4" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="0.0" x="9.0" y="9.0">
            <y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
        </y:GenericNode>
      </data>
    </node>
    <node id="n11">
      <data key="d6">
        <y:GenericNode configuration="com.yworks.sbgn.Process">
          <y:Geometry height="18.0" width="18.0" x="-634.1218344204844" y="-868.2463575468996"/>
          <y:Fill color="#FFFFFF" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" bottomInset="0" fontFamily="Arial" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="0.0" horizontalTextPosition="center" iconTextGap="4" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="0.0" x="9.0" y="9.0">
            <y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
        </y:GenericNode>
      </data>
    </node>
    <node id="n12">
      <data key="d6">
        <y:GenericNode configuration="com.yworks.sbgn.Process">
          <y:Geometry height="18.0" width="18.0" x="-670.1218344204844" y="-868.2463575468996"/>
          <y:Fill color="#FFFFFF" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" bottomInset="0" fontFamily="Arial" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="0.0" horizontalTextPosition="center" iconTextGap="4" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="0.0" x="9.0" y="9.0">
            <y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
        </y:GenericNode>
      </data>
    </node>
    <node id="n13">
      <data key="d6">
        <y:GenericNode configuration="com.yworks.sbgn.SimpleChemical">
          <y:Geometry height="32.0" width="140.0" x="-713.1218344204844" y="-810.2463575468996"/>
          <y:Fill color="#E4EAC4" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Arial" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="19.640625" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="122.53515625" x="8.732421875" y="6.1796875">β-D-fructose-1,6P2<y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
        </y:GenericNode>
      </data>
    </node>
    <node id="n14">
      <data key="d6">
        <y:GenericNode configuration="com.yworks.sbgn.Macromolecule">
          <y:Geometry height="40.0" width="80.0" x="-788.1218344204844" y="-879.2463575468996"/>
          <y:Fill color="#C2D4ED" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Arial" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="19.640625" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="50.689453125" x="14.6552734375" y="10.1796875">F1,6BP<y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
          <y:StyleProperties>
            <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radius" value="10"/>
          </y:StyleProperties>
        </y:GenericNode>
      </data>
    </node>
    <node id="n15">
      <data key="d6">
        <y:GenericNode configuration="com.yworks.sbgn.Macromolecule">
          <y:Geometry height="40.0" width="80.0" x="-578.1218344204844" y="-879.2463575468996"/>
          <y:Fill color="#C2D4ED" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Arial" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="19.640625" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="39.013671875" x="20.4931640625" y="10.1796875">PFK1<y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
          <y:StyleProperties>
            <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radius" value="10"/>
          </y:StyleProperties>
        </y:GenericNode>
      </data>
    </node>
    <node id="n16">
      <data key="d6">
        <y:GenericNode configuration="com.yworks.sbgn.SimpleChemical">
          <y:Geometry height="32.0" width="140.0" x="-424.6218483361479" y="-940.2463575468996"/>
          <y:Fill color="#E4EAC4" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Arial" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="19.640625" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="122.53515625" x="8.732421875" y="6.1796875">β-D-fructose-2,6P2<y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
        </y:GenericNode>
      </data>
    </node>
    <node id="n17">
      <data key="d6">
        <y:GenericNode configuration="com.yworks.sbgn.Process">
          <y:Geometry height="18.0" width="18.0" x="-488.4152823396744" y="-947.7365293422197"/>
          <y:Fill color="#FFFFFF" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" bottomInset="0" fontFamily="Arial" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="0.0" horizontalTextPosition="center" iconTextGap="4" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="0.0" x="9.0" y="9.0">
            <y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
        </y:GenericNode>
      </data>
    </node>
    <node id="n18">
      <data key="d6">
        <y:GenericNode configuration="com.yworks.sbgn.Process">
          <y:Geometry height="18.0" width="18.0" x="-488.4152823396744" y="-922.171148450434"/>
          <y:Fill color="#FFFFFF" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" bottomInset="0" fontFamily="Arial" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="0.0" horizontalTextPosition="center" iconTextGap="4" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="0.0" x="9.0" y="9.0">
            <y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
        </y:GenericNode>
      </data>
    </node>
    <node id="n19">
      <data key="d6">
        <y:GenericNode configuration="com.yworks.sbgn.Macromolecule">
          <y:Geometry height="40.0" width="80.0" x="-243.38994579450332" y="-1009.2463575468996"/>
          <y:Fill color="#C2D4ED" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Arial" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="19.640625" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="56.9033203125" x="11.54833984375" y="10.1796875">PFKFB2<y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
          <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="0.0" bottomInset="0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="18.0" horizontalTextPosition="center" iconData="3" iconTextGap="0" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="50.0" x="15.0" y="31.0">
            <y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.5" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
          <y:StyleProperties>
            <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radius" value="10"/>
          </y:StyleProperties>
        </y:GenericNode>
      </data>
    </node>
    <node id="n20">
      <data key="d6">
        <y:GenericNode configuration="com.yworks.sbgn.Process">
          <y:Geometry height="18.0" width="18.0" x="-212.38994579450332" y="-933.2463575468996"/>
          <y:Fill color="#FFFFFF" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" bottomInset="0" fontFamily="Arial" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="0.0" horizontalTextPosition="center" iconTextGap="4" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="0.0" x="9.0" y="9.0">
            <y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
        </y:GenericNode>
      </data>
    </node>
    <node id="n21">
      <data key="d6">
        <y:GenericNode configuration="com.yworks.sbgn.Macromolecule">
          <y:Geometry height="40.0" width="80.0" x="-243.38994579450332" y="-879.2463575468996"/>
          <y:Fill color="#C2D4ED" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Arial" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="19.640625" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="56.9033203125" x="11.54833984375" y="10.1796875">PFKFB2<y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
          <y:NodeLabel alignment="center" autoSizePolicy="content" borderDistance="0.0" bottomInset="0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="18.0" horizontalTextPosition="center" iconData="4" iconTextGap="0" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="50.0" x="15.0" y="31.0">
            <y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.5" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
          <y:StyleProperties>
            <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radius" value="10"/>
          </y:StyleProperties>
        </y:GenericNode>
      </data>
    </node>
    <node id="n22">
      <data key="d6">
        <y:GenericNode configuration="com.yworks.sbgn.SimpleChemical">
          <y:Geometry height="32.0" width="60.0" x="-399.59088065005767" y="-1277.8977169914597"/>
          <y:Fill color="#E4EAC4" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="30.25" x="14.875" y="5.755859375">ATP<y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
        </y:GenericNode>
      </data>
    </node>
    <node id="n23">
      <data key="d6">
        <y:GenericNode configuration="com.yworks.sbgn.Process">
          <y:Geometry height="18.0" width="18.0" x="-295.4904132222805" y="-1270.8977169914597"/>
          <y:Fill color="#FFFFFF" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" bottomInset="0" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="0.0" horizontalTextPosition="center" iconTextGap="4" leftInset="0" modelName="custom" rightInset="0" textColor="#000000" topInset="0" verticalTextPosition="center" visible="true" width="0.0" x="9.0" y="9.0">
            <y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
        </y:GenericNode>
      </data>
    </node>
    <node id="n24">
      <data key="d6">
        <y:GenericNode configuration="com.yworks.sbgn.Macromolecule">
          <y:Geometry height="40.0" width="80.0" x="-326.4904132222805" y="-1366.4326844325103"/>
          <y:Fill color="#C2D4ED" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Arial" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="19.640625" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="42.896484375" x="18.5517578125" y="10.1796875">ADCY<y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
          <y:StyleProperties>
            <y:Property class="java.lang.Integer" name="com.yworks.sbgn.style.radius" value="10"/>
          </y:StyleProperties>
        </y:GenericNode>
      </data>
    </node>
    <node id="n25">
      <data key="d6">
        <y:GenericNode configuration="com.yworks.sbgn.SimpleChemical">
          <y:Geometry height="32.0" width="60.0" x="-293.3899457945033" y="-1215.8977169914597"/>
          <y:Fill color="#E4EAC4" transparent="false"/>
          <y:BorderStyle color="#000000" type="line" width="1.0"/>
          <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="14" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="20.48828125" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="23.5234375" x="18.23828125" y="5.755859375">PPi<y:LabelModel>
              <y:SmartNodeLabelModel distance="4.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
            </y:ModelParameter>
          </y:NodeLabel>
        </y:GenericNode>
      </data>
    </node>
    <edge id="e0" source="n4" target="n6">
      <data key="d10">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="delta"/>
          <y:EdgeLabel alignment="center" anchorX="-20.49820739601482" anchorY="24.13776120913758" backgroundColor="#FFFFFF" configuration="AutoFlippingLabel" distance="2.0" fontFamily="Dialog" fontSize="12" fontStyle="plain" height="18.1328125" horizontalTextPosition="center" iconTextGap="4" lineColor="#000000" modelName="custom" preferredPlacement="center_on_edge" ratio="0.5" textColor="#000000" upX="0.9998868666200132" upY="0.015041740617757912" verticalTextPosition="bottom" visible="true" width="11.587890625" x="-20.672509441103017" y="24.13776120913758">2<y:LabelModel>
              <y:RotatedSliderEdgeLabelModel angle="0.0" autoRotationEnabled="true" distance="2.0" distanceRelativeToEdge="true" mode="side_slider"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:RotatedSliderEdgeLabelModelParameter invertingSign="false" ratio="0.5" segment="1"/>
            </y:ModelParameter>
            <y:PreferredPlacementDescriptor angle="0.0" angleOffsetOnRightSide="0" angleReference="relative_to_edge_flow" angleRotationOnRightSide="co" distance="-1.0" placement="center" side="on_edge" sideReference="relative_to_edge_flow"/>
          </y:EdgeLabel>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e1" source="n5" target="n4">
      <data key="d10">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="none"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e2" source="n2" target="n5">
      <data key="d10">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="delta"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e3" source="n3" target="n2">
      <data key="d10">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="none"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e4" source="n4" target="n1">
      <data key="d10">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="0.0">
            <y:Point x="-84.04870136708445" y="-989.2463575468996"/>
          </y:Path>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="delta"/>
          <y:EdgeLabel alignment="center" configuration="AutoFlippingLabel" distance="2.0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="4.0" horizontalTextPosition="center" iconTextGap="4" modelName="custom" preferredPlacement="anywhere" ratio="0.5" textColor="#000000" verticalTextPosition="bottom" visible="true" width="4.0" x="6.389636174615248" y="42.95246835342698">
            <y:LabelModel>
              <y:SmartEdgeLabelModel autoRotationEnabled="false" defaultAngle="0.0" defaultDistance="10.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartEdgeLabelModelParameter angle="0.0" distance="27.806491915951693" distanceToCenter="false" position="right" ratio="0.18374655662855727" segment="-1"/>
            </y:ModelParameter>
            <y:PreferredPlacementDescriptor angle="0.0" angleOffsetOnRightSide="0" angleReference="absolute" angleRotationOnRightSide="co" distance="-1.0" frozen="true" placement="anywhere" side="anywhere" sideReference="relative_to_edge_flow"/>
          </y:EdgeLabel>
          <y:BendStyle smoothed="true"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e5" source="n0" target="n2">
      <data key="d10">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="0.0">
            <y:Point x="-84.04870136708445" y="-1261.8977169914597"/>
          </y:Path>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="none"/>
          <y:EdgeLabel alignment="center" backgroundColor="#FFFFFF" configuration="AutoFlippingLabel" distance="2.0" fontFamily="Dialog" fontSize="12" fontStyle="plain" height="18.1328125" horizontalTextPosition="center" iconTextGap="4" lineColor="#000000" modelName="custom" preferredPlacement="center_on_edge" ratio="0.5" textColor="#000000" verticalTextPosition="bottom" visible="true" width="11.587890625" x="31.201438049467015" y="1.9999880866653257">4<y:LabelModel>
              <y:RotatedSliderEdgeLabelModel angle="0.0" autoRotationEnabled="true" distance="2.0" distanceRelativeToEdge="true" mode="side_slider"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:RotatedSliderEdgeLabelModelParameter invertingSign="false" ratio="0.3333333333333333" segment="0"/>
            </y:ModelParameter>
            <y:PreferredPlacementDescriptor angle="0.0" angleOffsetOnRightSide="0" angleReference="relative_to_edge_flow" angleRotationOnRightSide="co" distance="-1.0" placement="center" side="on_edge" sideReference="relative_to_edge_flow"/>
          </y:EdgeLabel>
          <y:BendStyle smoothed="true"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e6" source="n10" target="n8">
      <data key="d10">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="delta"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e7" source="n10" target="n7">
      <data key="d10">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="delta"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e8" source="n9" target="n10">
      <data key="d10">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="-14.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="white_circle"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e9" source="n14" target="n12">
      <data key="d10">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="-14.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="white_circle"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e10" source="n13" target="n12">
      <data key="d10">
        <y:PolyLineEdge>
          <y:Path sx="-18.0" sy="0.0" tx="0.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="none"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e11" source="n12" target="n8">
      <data key="d10">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="-18.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="delta"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e12" source="n11" target="n13">
      <data key="d10">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="18.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="delta"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e13" source="n8" target="n11">
      <data key="d10">
        <y:PolyLineEdge>
          <y:Path sx="18.0" sy="0.0" tx="0.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="none"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e14" source="n15" target="n11">
      <data key="d10">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="14.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="white_circle"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e15" source="n17" target="n16">
      <data key="d10">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="-65.0" ty="-14.490171795320123"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="delta"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e16" source="n18" target="n8">
      <data key="d10">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="65.0" ty="11.075209096465699"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="delta"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e17" source="n8" target="n17">
      <data key="d10">
        <y:PolyLineEdge>
          <y:Path sx="60.78765463939162" sy="-14.490171795320123" tx="0.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="none"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e18" source="n16" target="n18">
      <data key="d10">
        <y:PolyLineEdge>
          <y:Path sx="-65.13952275658391" sy="11.075209096465699" tx="0.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="none"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e19" source="n20" target="n21">
      <data key="d10">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="delta"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e20" source="n21" target="n18">
      <data key="d10">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="14.0">
            <y:Point x="-479.4152823396744" y="-859.2463575468996"/>
          </y:Path>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="white_circle"/>
          <y:EdgeLabel alignment="center" configuration="AutoFlippingLabel" distance="2.0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="4.0" horizontalTextPosition="center" iconTextGap="4" modelName="custom" preferredPlacement="anywhere" ratio="0.5" textColor="#000000" verticalTextPosition="bottom" visible="true" width="4.0" x="-120.0172991256826" y="-32.00001965627462">
            <y:LabelModel>
              <y:SmartEdgeLabelModel autoRotationEnabled="false" defaultAngle="0.0" defaultDistance="10.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartEdgeLabelModelParameter angle="0.0" distance="30.0" distanceToCenter="true" position="right" ratio="0.5" segment="0"/>
            </y:ModelParameter>
            <y:PreferredPlacementDescriptor angle="0.0" angleOffsetOnRightSide="0" angleReference="absolute" angleRotationOnRightSide="co" distance="-1.0" frozen="true" placement="anywhere" side="anywhere" sideReference="relative_to_edge_flow"/>
          </y:EdgeLabel>
          <y:BendStyle smoothed="true"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e21" source="n19" target="n17">
      <data key="d10">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="-14.0">
            <y:Point x="-479.4152823396744" y="-989.2463575468996"/>
          </y:Path>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="white_circle"/>
          <y:EdgeLabel alignment="center" configuration="AutoFlippingLabel" distance="2.0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="4.0" horizontalTextPosition="center" iconTextGap="4" modelName="custom" preferredPlacement="anywhere" ratio="0.5" textColor="#000000" verticalTextPosition="bottom" visible="true" width="4.0" x="-120.0172991256826" y="-32.00001965627462">
            <y:LabelModel>
              <y:SmartEdgeLabelModel autoRotationEnabled="false" defaultAngle="0.0" defaultDistance="10.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartEdgeLabelModelParameter angle="0.0" distance="30.0" distanceToCenter="true" position="right" ratio="0.5" segment="0"/>
            </y:ModelParameter>
            <y:PreferredPlacementDescriptor angle="0.0" angleOffsetOnRightSide="0" angleReference="absolute" angleRotationOnRightSide="co" distance="-1.0" frozen="true" placement="anywhere" side="anywhere" sideReference="relative_to_edge_flow"/>
          </y:EdgeLabel>
          <y:BendStyle smoothed="true"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e22" source="n19" target="n20">
      <data key="d10">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="30.444447312894056" tx="0.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="none"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e23" source="n6" target="n20">
      <data key="d10">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="12.870726157191712" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="white_circle"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e24" source="n23" target="n0">
      <data key="d10">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="delta"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e25" source="n22" target="n23">
      <data key="d10">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="0.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="none"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e26" source="n24" target="n23">
      <data key="d10">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="-14.0"/>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="white_circle"/>
          <y:BendStyle smoothed="false"/>
        </y:PolyLineEdge>
      </data>
    </edge>
    <edge id="e27" source="n23" target="n25">
      <data key="d10">
        <y:PolyLineEdge>
          <y:Path sx="0.0" sy="0.0" tx="0.0" ty="0.0">
            <y:Point x="-263.3899457945033" y="-1261.8977169914597"/>
          </y:Path>
          <y:LineStyle color="#000000" type="line" width="1.0"/>
          <y:Arrows source="none" target="delta"/>
          <y:EdgeLabel alignment="center" configuration="AutoFlippingLabel" distance="2.0" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" hasText="false" height="4.0" horizontalTextPosition="center" iconTextGap="4" modelName="custom" preferredPlacement="anywhere" ratio="0.5" textColor="#000000" verticalTextPosition="bottom" visible="true" width="4.0" x="5.071722347076843" y="27.999988086665326">
            <y:LabelModel>
              <y:SmartEdgeLabelModel autoRotationEnabled="false" defaultAngle="0.0" defaultDistance="10.0"/>
            </y:LabelModel>
            <y:ModelParameter>
              <y:SmartEdgeLabelModelParameter angle="0.0" distance="30.0" distanceToCenter="true" position="right" ratio="0.5" segment="0"/>
            </y:ModelParameter>
            <y:PreferredPlacementDescriptor angle="0.0" angleOffsetOnRightSide="0" angleReference="absolute" angleRotationOnRightSide="co" distance="-1.0" frozen="true" placement="anywhere" side="anywhere" sideReference="relative_to_edge_flow"/>
          </y:EdgeLabel>
          <y:BendStyle smoothed="true"/>
        </y:PolyLineEdge>
      </data>
    </edge>
  </graph>
  <data key="d7">
    <y:Resources>
      <y:Resource id="1">
        <yed:NodeRealizerIcon>
          <y:GenericNode configuration="com.yworks.sbgn.StateVariable">
            <y:Geometry height="18.0" width="40.0" x="0.0" y="0.0"/>
            <y:Fill color="#FFFFFF" transparent="false"/>
            <y:BorderStyle color="#000000" type="line" width="1.0"/>
            <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="10" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="15.77734375" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="30.162109375" x="4.9189453125" y="1.111328125">cAMP<y:LabelModel>
                <y:SmartNodeLabelModel distance="4.0"/>
              </y:LabelModel>
              <y:ModelParameter>
                <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
              </y:ModelParameter>
            </y:NodeLabel>
          </y:GenericNode>
        </yed:NodeRealizerIcon>
      </y:Resource>
      <y:Resource id="2">
        <yed:NodeRealizerIcon>
          <y:GenericNode configuration="com.yworks.sbgn.StateVariable">
            <y:Geometry height="18.0" width="40.0" x="0.0" y="0.0"/>
            <y:Fill color="#FFFFFF" transparent="false"/>
            <y:BorderStyle color="#000000" type="line" width="1.0"/>
            <y:NodeLabel alignment="center" autoSizePolicy="content" fontFamily="Dialog" fontSize="10" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="15.77734375" horizontalTextPosition="center" iconTextGap="4" modelName="custom" textColor="#000000" verticalTextPosition="center" visible="true" width="30.162109375" x="4.9189453125" y="1.111328125">cAMP<y:LabelModel>
                <y:SmartNodeLabelModel distance="4.0"/>
              </y:LabelModel>
              <y:ModelParameter>
                <y:SmartNodeLabelModelParameter labelRatioX="0.0" labelRatioY="0.0" nodeRatioX="0.0" nodeRatioY="0.0" offsetX="0.0" offsetY="0.0" upX="0.0" upY="-1.0"/>
              </y:ModelParameter>
            </y:NodeLabel>
          </y:GenericNode>
        </yed:NodeRealizerIcon>
      </y:Resource>
      <y:Resource id="3">
        <yed:NodeRealizerIcon>
          <y:GenericNode configuration="com.yworks.sbgn.StateVariable">
            <y:Geometry height="18.0" width="50.0" x="0.0" y="0.0"/>
            <y:Fill color="#FFFFFF" transparent="false"/>
            <y:BorderStyle color="#000000" type="line" width="1.0"/>
            <y:NodeLabel alignment="right" autoSizePolicy="content" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="18.1328125" horizontalTextPosition="center" iconTextGap="4" modelName="internal" modelPosition="r" textColor="#000000" verticalTextPosition="center" visible="true" width="35.939453125" x="10.060546875" y="-0.06640625">@S36</y:NodeLabel>
          </y:GenericNode>
        </yed:NodeRealizerIcon>
      </y:Resource>
      <y:Resource id="4">
        <yed:NodeRealizerIcon>
          <y:GenericNode configuration="com.yworks.sbgn.StateVariable">
            <y:Geometry height="18.0" width="50.0" x="0.0" y="0.0"/>
            <y:Fill color="#FFFFFF" transparent="false"/>
            <y:BorderStyle color="#000000" type="line" width="1.0"/>
            <y:NodeLabel alignment="right" autoSizePolicy="content" fontFamily="Dialog" fontSize="12" fontStyle="plain" hasBackgroundColor="false" hasLineColor="false" height="18.1328125" horizontalTextPosition="center" iconTextGap="4" modelName="internal" modelPosition="r" textColor="#000000" verticalTextPosition="center" visible="true" width="42.572265625" x="3.427734375" y="-0.06640625">P@S36</y:NodeLabel>
          </y:GenericNode>
        </yed:NodeRealizerIcon>
      </y:Resource>
    </y:Resources>
  </data>
</graphml>
