Downloads:   GraphML   SBGN-ML   CellDesigner   MINERVA   Newt  

Contributors

Tatiana Serebriyskaya, Valeriya Berzhitskaya; John Albanese (annotation)

Description

Cyclic AMP (cAMP) is one of the key second messengers in the cell, and regulation of cAMP hydrolysis is an important mechanism of modulation of intracellular signals.

References

1. KEGG Pathway Maps: Insulin signaling pathway
2. Database dbPTM: PDE3B_HUMAN
3. Degerman E, Ahmad F, Chung YW, Guirguis E, Omar B, Stenson L, Manganiello V. From PDE3B to the regulation of energy homeostasis. Curr Opin Pharmacol. 2011 Dec;11(6):676-82. PMID: 22001403
4. Tsubai T, Noda Y, Ito K, Nakao M, Seino Y, Oiso Y4, Hamada Y. Insulin elevates leptin secretion and mRNA levels via cyclic AMP in 3T3-L1 adipocytes deprived of glucose. Heliyon. 2016 Nov 16;2(11):e00194. PMID: 27896318
5. DiPilato LM, Ahmad F, Harms M, Seale P, Manganiello V, Birnbaum MJ. The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin. Mol Cell Biol. 2015 Aug;35(16):2752-60. PMID: 26031333
6. Charles MS, Drunalini Perera PN, Doycheva DM, Tang J. Granulocyte-colony stimulating factor activates JAK2/PI3K/PDE3B pathway to inhibit corticosterone synthesis in a neonatal hypoxic-ischemic brain injury rat model. Exp Neurol. 2015 Oct;272:152-9. PMID: 25816736
7. Omar B, Zmuda-Trzebiatowska E, Manganiello V, Göransson O, Degerman E. Regulation of AMP-activated protein kinase by cAMP in adipocytes: roles for phosphodiesterases, protein kinase B, protein kinase A, Epac and lipolysis. Cell Signal. 2009 May;21(5):760-6. PMID: 19167487](https://www.ncbi.nlm.nih.gov/pubmed/19167487)
8. Vanhaesebroeck B, Alessi DR. The PI3K-PDK1 connection: more than just a road to PKB. Biochem J. 2000 Mar 15;346 Pt 3:561-76. PMID: 10698680
9. Degerman E, Landström TR, Wijkander J, Holst LS, Ahmad F, Belfrage P, Manganiello V. Phosphorylation and activation of hormone-sensitive adipocyte phosphodiesterase type 3B. Methods. 1998 Jan;14(1):43-53. PMID: 9500857