Regulation of acetyl-CoA synthesis

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Contributors

Adrien Rougny, John Albanese

Description

ATP citrate lyase (ACLY) catalyses the transformation of citrate, which is an intermediary product of the metabolism of carbohydrates, into acetyl-CoA. Acetyl-CoA plays a major role in the fatty acid synthesis pathways, but also in gene expression, through the acetylation of histones. Hence, ACLY (i) serves as a bridge between carbohydrate and fatty acid metabolism, and (ii) is a key player in the regulation of gene expression, in particular the one mediated by glucose availability.

References

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