Regulation of acetyl-CoA synthesis

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Description

ATP citrate lyase (ACLY) catalyses the transformation of citrate, which is an intermediary product of the metabolism of carbohydrates, into acetyl-CoA. Acetyl-CoA plays a major role in the fatty acid synthesis pathways, but also in gene expression, through the acetylation of histones. ACLY therefore (i) serves as a bridge between carbohydrate and fatty acid metabolism, and (ii) is a key player in the regulation of gene expression, in particular the one mediated by glucose availability.

References

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Contributors

Adrien Rougny1,2,3, John Albanese4

Affiliations
  1. 1Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg
  2. 2Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan
  3. 3Computational Bio Big Data Open Innovation Laboratory, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan
  4. 4University of Connecticut School of Medicine, Farmington, USA