Regulation of eicosanoid metabolism by aspirin

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References

  1. Awtry EH, Loscalzo J. Aspirin. Circulation. 2000 Mar 14;101(10):1206-18. doi: 10.1161/01.cir.101.10.1206. PMID: 10715270.
  2. Chiang N, Bermudez EA, Ridker PM, Hurwitz S, Serhan CN. Aspirin triggers antiinflammatory 15-epi-lipoxin A4 and inhibits thromboxane in a randomized human trial. Proc Natl Acad Sci U S A. 2004 Oct 19;101(42):15178-83. doi: 10.1073/pnas.0405445101. PMID: 15471991.
  3. Lucido MJ, Orlando BJ, Vecchio AJ, Malkowski MG. Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry. Biochemistry. 2016 Mar 1;55(8):1226-38. doi: 10.1021/acs.biochem.5b01378. PMID: 26859324.
  4. Ornelas A, Zacharias-Millward N, Menter DG, Davis JS, Lichtenberger L, Hawke D, Hawk E, Vilar E, Bhattacharya P, Millward S. Beyond COX-1: the effects of aspirin on platelet biology and potential mechanisms of chemoprevention. Cancer Metastasis Rev. 2017 Jun;36(2):289-303. doi: 10.1007/s10555-017-9675-z. PMID: 28762014.
  5. Rowlinson SW, Crews BC, Goodwin DC, Schneider C, Gierse JK, Marnett LJ. Spatial requirements for 15-(R)-hydroxy-5Z,8Z,11Z, 13E-eicosatetraenoic acid synthesis within the cyclooxygenase active site of murine COX-2. Why acetylated COX-1 does not synthesize 15-(R)-hete. J Biol Chem. 2000 Mar 3;275(9):6586-91. doi: 10.1074/jbc.275.9.6586. PMID: 10692466.

Contributors

Alexander Mazein1,2, Maria del Carmen Heredia3

Affiliations
  1. 1Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg
  2. 2Department of Cancer Research, Luxembourg Institute of Health, Strassen, Luxembourg
  3. 3University of Connecticut School of Medicine, Farmington, USA