Regulation of nitric oxide production - eNOS pathway

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References

  1. Busconi L, Michel T. Endothelial nitric oxide synthase. N-terminal myristoylation determines subcellular localization. J Biol Chem. 1993 Apr 25;268(12):8410-3. doi: 10.1016/S0021-9258(18)52889-1. PMID: 7682550.
  2. Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature. 1999 Jun 10;399(6736):601-5. doi: 10.1038/21224. PMID: 10376603.
  3. Förstermann U, Sessa WC. Nitric oxide synthases: regulation and function. Eur Heart J. 2012 Apr;33(7):829-37, 837a-837d. doi: 10.1093/eurheartj/ehr304. PMID: 21890489.
  4. García-Cardeña G, Fan R, Shah V, Sorrentino R, Cirino G, Papapetropoulos A, Sessa WC. Dynamic activation of endothelial nitric oxide synthase by Hsp90. Nature. 1998 Apr 23;392(6678):821-4. doi: 10.1038/33934. PMID: 9580552.
  5. Icking A, Matt S, Opitz N, Wiesenthal A, Müller-Esterl W, Schilling K. NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS. J Cell Sci. 2005 Nov 1;118(Pt 21):5059-69. doi: 10.1242/jcs.02620. PMID: 16234328.
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  7. Liu J, García-Cardeña G, Sessa WC. Biosynthesis and palmitoylation of endothelial nitric oxide synthase: mutagenesis of palmitoylation sites, cysteines-15 and/or -26, argues against depalmitoylation-induced translocation of the enzyme. Biochemistry. 1995 Sep 26;34(38):12333-40. doi: 10.1021/bi00038a029. PMID: 7547976.
  8. Liu X, El-Mahdy MA, Boslett J, Varadharaj S, Hemann C, Abdelghany TM, Ismail RS, Little SC, Zhou D, Thuy LT, Kawada N, Zweier JL. Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall. Nat Commun. 2017 Apr 10;8:14807. doi: 10.1038/ncomms14807. PMID: 28393874.
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  10. Reactome: Metabolism of nitric oxide: NOS3 activation and regulation. Reactome:R-HSA-202131.

Contributors

Olga Ivanova1,2,3, John Albanese4

Affiliations
  1. 1Vrije Universiteit Amsterdam, Amsterdam, Netherlands
  2. 2Institute for Computational Biomedicine, Heidelberg University Hospital and Heidelberg University, Faculty of Medicine, Heidelberg, Germany
  3. 3Respiratory Medicine, Academic Medical Center, Amsterdam, Netherlands
  4. 4University of Connecticut School of Medicine, Farmington, USA