Regulation of mevalonate synthesis

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References

  1. Ching YP, Kobayashi T, Tamura S, Hardie DG. Specificity of different isoforms of protein phosphatase-2A and protein phosphatase-2C studied using site-directed mutagenesis of HMG-CoA reductase. FEBS Lett. 1997 Jul 14;411(2-3):265-8. doi: 10.1016/s0014-5793(97)00712-6. PMID: 9271218.
  2. Clarke PR, Hardie DG. Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver. EMBO J. 1990 Aug;9(8):2439-46. doi: 10.1002/j.1460-2075.1990.tb07420.x. PMID: 2369897.
  3. Goldstein JL, Brown MS. Regulation of the mevalonate pathway. Nature. 1990 Feb 1;343(6257):425-30. doi: 10.1038/343425a0. PMID: 1967820.
  4. Hawley SA, Pan DA, Mustard KJ, Ross L, Bain J, Edelman AM, Frenguelli BG, Hardie DG. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab. 2005 Jul;2(1):9-19. doi: 10.1016/j.cmet.2005.05.009. PMID: 16054095.
  5. Joseph BK, Liu HY, Francisco J, Pandya D, Donigan M, Gallo-Ebert C, Giordano C, Bata A, Nickels JT. Inhibition of AMP Kinase by the Protein Phosphatase 2A Heterotrimer, PP2APpp2r2d. J Biol Chem. 2015 Apr 24;290(17):10588-98. doi: 10.1074/jbc.M114.626259. PMID: 25694423.
  6. Miziorko HM. Enzymes of the mevalonate pathway of isoprenoid biosynthesis. Arch Biochem Biophys. 2011 Jan 15;505(2):131-43. doi: 10.1016/j.abb.2010.09.028. PMID: 20932952.
  7. Pappa E, Mazein A, Watterson S, Roy D, Ghazal P. Regulation of HMGCR in the mevalonate pathway. Figshare. 2012. doi: 10.6084/m9.figshare.105160.v2.
  8. Reactome: Cholesterol biosynthesis. Reactome:R-HSA-191273.
  9. Reactome: Phosphorylated AMPK binds AMP. Reactome:R-HSA-380930.
  10. Sharpe LJ, Brown AJ. Controlling cholesterol synthesis beyond 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR). J Biol Chem. 2013 Jun 28;288(26):18707-15. doi: 10.1074/jbc.R113.479808. PMID: 23696639.

Contributors

James Greene1, Michael L. Blinov1, Alexander Mazein2,3

Affiliations
  1. 1University of Connecticut School of Medicine, Farmington, USA
  2. 2Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg
  3. 3Department of Cancer Research, Luxembourg Institute of Health, Strassen, Luxembourg