Regulation of mevalonate synthesis

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Contributors

James Greene, Michael Blinov, Alexander Mazein

References

  1. Ching YP, Kobayashi T, Tamura S, Hardie DG. Specificity of different isoforms of protein phosphatase-2A and protein phosphatase-2C studied using site-directed mutagenesis of HMG-CoA reductase. FEBS Lett. 1997 Jul 14;411(2-3):265-8. doi: 10.1016/s0014-5793(97)00712-6. PMID: 9271218.
  2. Clarke PR, Hardie DG. Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver. EMBO J. 1990 Aug;9(8):2439-46. doi: 10.1002/j.1460-2075.1990.tb07420.x. PMID: 2369897.
  3. Goldstein JL, Brown MS. Regulation of the mevalonate pathway. Nature. 1990 Feb 1;343(6257):425-30. doi: 10.1038/343425a0. PMID: 1967820.
  4. Hawley SA, Pan DA, Mustard KJ, Ross L, Bain J, Edelman AM, Frenguelli BG, Hardie DG. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab. 2005 Jul;2(1):9-19. doi: 10.1016/j.cmet.2005.05.009. PMID: 16054095.
  5. Joseph BK, Liu HY, Francisco J, Pandya D, Donigan M, Gallo-Ebert C, Giordano C, Bata A, Nickels JT. Inhibition of AMP Kinase by the Protein Phosphatase 2A Heterotrimer, PP2APpp2r2d. J Biol Chem. 2015 Apr 24;290(17):10588-98. doi: 10.1074/jbc.M114.626259. PMID: 25694423.
  6. Miziorko HM. Enzymes of the mevalonate pathway of isoprenoid biosynthesis. Arch Biochem Biophys. 2011 Jan 15;505(2):131-43. doi: 10.1016/j.abb.2010.09.028. PMID: 20932952.
  7. Pappa E, Mazein A, Watterson S, Roy D, Ghazal P. Regulation of HMGCR in the mevalonte pathway. Figshare. 2012. doi: 10.6084/m9.figshare.105160.v2.
  8. Reactome: Cholesterol biosynthesis. Reactome:R-HSA-191273.
  9. Reactome: Phosphorylated AMPK binds AMP. Reactome:R-HSA-380930.
  10. Sharpe LJ, Brown AJ. Controlling cholesterol synthesis beyond 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR). J Biol Chem. 2013 Jun 28;288(26):18707-15. doi: 10.1074/jbc.R113.479808. PMID: 23696639.