Regulation of mevalonate synthesis

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James Greene, Michael Blinov, Alexander Mazein


  1. Miziorko, H. M. (2011). Enzymes of the mevalonate pathway of isoprenoid biosynthesis. Archives of biochemistry and biophysics, 505(2), 131-143.
  2. Goldstein, J. L., and Brown, S. B. (1990) Regulation of the mevalonate pathway. Nature 343, 425−430
  3. Reactome Pathways
  4. Clarke, P. R., & Hardie, D. G. (1990). Regulation of HMG‐CoA reductase: identification of the site phosphorylated by the AMP‐activated protein kinase in vitro and in intact rat liver. The EMBO journal, 9(8), 2439-2446.
  5. Sharpe, L. J., & Brown, A. J. (2013). Controlling cholesterol synthesis beyond 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR). Journal of Biological Chemistry, 288(26), 18707-18715.
  6. Joseph, B. K., Liu, H. Y., Francisco, J., Pandya, D., Donigan, M., Gallo-Ebert, C., … & Nickels, J. T. (2015). Inhibition of AMP kinase by the protein phosphatase 2A heterotrimer, PP2APpp2r2d. Journal of Biological Chemistry, 290(17), 10588-10598.
  7. Pang Ching, Y., Kobayashi, T., Tamura, S., & Grahame Hardie, D. (1997). Specificity of different isoforms of protein phosphatase‐2A and protein phosphatase‐2C studied using site‐directed mutagenesis of HMG‐CoA reductase. FEBS letters, 411(2-3), 265-268.
  8. Hawley, S. A., Pan, D. A., Mustard, K. J., Ross, L., Bain, J., Edelman, A. M., … & Hardie, D. G. (2005). Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase. Cell metabolism, 2(1), 9-19.
  9. Reactome Pathways
  10. Figshare: Pappa et al., 2012, Regulation of HMGCR in the mevalonte pathway,