Reactome-Recon List 2

This list includes proteins that Recon2 lists as parts of enzyme complexes and that participate in signalling processes in Reactome pathways as reactants or products, directly or within a Reactome complex. Table 2a includes phosphorylation processes, while Tables 2b and 2c include other types of processes. The MRegAtlas column links a protein-process pair to the map that draws that process.

Downloads (all tables):   XLSX   CSV  

Table 2a. Signalling phosphorylation processes & Recon2 compounds-catalysers

UniProtHGNCReactome processesMRegAtlas
P11182DBTBCKDK phosphorylates BCKDHBCAA
P11182DBTPPM1K dephosphorylates p-BCKDHBCAA
P46976GYG1EPM2A dimer dephosphorylates phosphoglycogen-GYG1
P46976GYG1Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1
O15488GYG2EPM2A dimer dephosphorylates phosphoglycogen-GYG2
P13807GYS1EPM2A dimer dephosphorylates phosphoglycogen-GYG1
P13807GYS1Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1
P54840GYS2EPM2A dimer dephosphorylates phosphoglycogen-GYG2
P43034PAFAH1B1Plk1-mediated phosphorylation of Nlp
O00330PDHXPDK isozymes phosphorylate PDHC subunit E1PDH
O00330PDHXPDP1,2 dephosphorylate p-lipo-PDHPDH
P42336PIK3CABinding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
P42336PIK3CAPhosphorylated GAB1 recruits PI3K to MET
P42336PIK3CAPhosphorylated heterodimers of ERBB2 ECD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K
P42336PIK3CAPhosphorylated heterodimers of ERBB2 KD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K
P42336PIK3CAPhosphorylated heterodimers of ERBB2 KD mutants and ERBB3 bind PI3K
P42336PIK3CAPhosphorylated KIT mutants bind PI3K
P27986PIK3R1Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
P27986PIK3R1FLT3 fusions recruit PIK3R1 through phosphorylated GAB2
P27986PIK3R1FLT3 mutants recruit PIK3R1 through phosphorylated GAB2
P27986PIK3R1Phosphorylated GAB1 recruits PI3K to MET
P27986PIK3R1Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K
P27986PIK3R1Phosphorylated heterodimers of ERBB2 KD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K
P27986PIK3R1Phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 bind PI3K

Table 2b. Other signalling processes & Recon2 compounds-catalysers

UniProtHGNCReactome processesMRegAtlas
P09110ACAA1TYSND1 cleaves ACAA1
Q13085ACACAHLCS biotinylates ACACA:Mn2+
Q13085ACACATranscriptional activation of ACACA by ChREBP:MLX
O00763ACACBHLCS biotinylates ACACB
O00763ACACBTranscriptional activation of ACACB by ChREBP:MLX
Q15067ACOX1TYSND1 cleaves ACOX1
Q9BXJ7AMNapoA-I binds to CUBN:AMN
Q9BXJ7AMNCUBN:AMN binds CBLIF:RCbl
Q9BXJ7AMNCUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome
Q9UN42ATP1B4ATP1B4 binds SNW1
P51164ATP4BATP4A:ATP4B binds PPIs
Q9UI12ATP6V1HDegradation of CD4
Q9UI12ATP6V1HDegradation of CD8
Q9UI12ATP6V1HFormation of CD4:Nef:AP-2 Complex:v-ATPase Complex
Q9UI12ATP6V1HFormation of CD8:Nef:AP-2 Complex:v-ATPase Complex
Q9UI12ATP6V1HInternalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex
Q9UI12ATP6V1HInternalization of the CD8:Nef:AP-2 Complex:v-ATPase Complex
Q9UI12ATP6V1HPtpA binds ATP6V1H
P15291B4GALT1Association of ADAM and B4GALT1 With ZP3
P15291B4GALT1B4GALT1 binds LALBA
P27352CBLIFCBLIF binds RCbl
P27352CBLIFCUBN:AMN binds CBLIF:RCbl
P27352CBLIFCUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome
P20674COX5ACO binds to Cytochrome c oxidase
P20674COX5AMetallochaperone inserts Cu2+ into MT-CO1
P20674COX5AMT-CO1 and MT-CO2 complexes associate, installing heme moieties
P20674COX5AMT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex
P20674COX5ATIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC
P09669COX6CCO binds to Cytochrome c oxidase
P09669COX6CMetallochaperone inserts Cu2+ into MT-CO1
P09669COX6CMT-CO1 and MT-CO2 complexes associate, installing heme moieties
P09669COX6CMT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex
P09669COX6CTIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC
P24311COX7BCO binds to Cytochrome c oxidase
P24311COX7BMT-CO1 and MT-CO2 complexes associate, installing heme moieties
P24311COX7BMT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex
P15954COX7CCO binds to Cytochrome c oxidase
P15954COX7CMT-CO1 and MT-CO2 complexes associate, installing heme moieties
P15954COX7CMT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex
O00483COXFA4MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex
O60494CUBNapoA-I binds to CUBN:AMN
O60494CUBNCUBN binds GC:25(OH)D
O60494CUBNCUBN:AMN binds CBLIF:RCbl
O60494CUBNCUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome
O60494CUBNEndocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen
O60494CUBNLGMN hydrolyzes GC, releasing CUBN and 25(OH)D
O60494CUBNLRP2-mediated uptake of extracellular CUBN:GC:25(OH)D
P08574CYC1Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH
P11182DBTDLD dimer dehydrogenates dihydrolipoyl
P10515DLATDLAT trimer transfers acetyl to CoA
P10515DLATDLD dimer dehydrogenates dihydrolipoyl
P10515DLATLIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT
P10515DLATPDH E1 decarboxylates PYR, transferring acetyl to DLAT
P10515DLATSIRT4 cleaves lipoyl from DLAT
P36957DLSTDHTKD1 dimer decarboxylates 2-OA
P36957DLSTDLD dimer dehydrogenates dihydrolipoyl
P36957DLSTDLD dimer dehydrogenates dihydrolipoyl
P36957DLSTDLST transfers glutaryl to CoA
P36957DLSTDLST transfers succinyl to CoA
P36957DLSTOGDH dimer decarboxylates 2-OG
P13804ETFAETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2
P13804ETFAReducing equivalents from beta-oxidation of fatty acids transfer to ETF
P38117ETFBETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB
P38117ETFBETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2
P38117ETFBReducing equivalents from beta-oxidation of fatty acids transfer to ETF
P23434GCSHAMT transfers NH2CH2 from GCSH:SAMDLL to THF
P23434GCSHDLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate
P23434GCSHLIAS synthesizes lipoyl-GCSH
P23434GCSHLIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST
P23434GCSHLIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT
P23434GCSHLIPT2 transfers octanoyl group to GCSH
P23434GCSHPXLP-K754-GLDC dimer decarboxylates Gly
P46976GYG1Autoglucosylation of GYG1 complexed with GYS1-a
P46976GYG1Autoglucosylation of GYG1 complexed with GYS1-b
P46976GYG1EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG1 complex
P46976GYG1GAA hydrolyzes lysosomal glycogen
P46976GYG1GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a
P46976GYG1GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b
P46976GYG1glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]
P46976GYG1GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1
P46976GYG1GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1
P46976GYG1NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1
P46976GYG1poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]
P46976GYG1PPP1R3C binds to glycogen:GYG1:GYS1
O15488GYG2Autoglucosylation of GYG2 complexed with GYS2-a
O15488GYG2Autoglucosylation of GYG2 complexed with GYS2-b
O15488GYG2EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG2 complex
O15488GYG2GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a
O15488GYG2glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL]
O15488GYG2GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2
O15488GYG2GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2
O15488GYG2NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2
O15488GYG2poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL]
O15488GYG2PPP1R3C binds to glycogen:GYG2:GYS2
P13807GYS1Autoglucosylation of GYG1 complexed with GYS1-a
P13807GYS1Autoglucosylation of GYG1 complexed with GYS1-b
P13807GYS1EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG1 complex
P13807GYS1GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a
P13807GYS1GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b
P13807GYS1GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1
P13807GYS1GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1Glycogen
P13807GYS1NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1
P13807GYS1PPP1R3C binds to glycogen:GYG1:GYS1
P54840GYS2Autoglucosylation of GYG2 complexed with GYS2-a
P54840GYS2Autoglucosylation of GYG2 complexed with GYS2-b
P54840GYS2EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG2 complex
P54840GYS2GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a
P54840GYS2GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2
P54840GYS2GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2Glycogen
P54840GYS2NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2
P54840GYS2PPP1R3C binds to glycogen:GYG2:GYS2
Q9UBK5HCSTNKG2D homodimer interacting with ligands
P51659HSD17B4TYSND1 cleaves HSD17B4
P00709LALBAB4GALT1 binds LALBA
P00338LDHACTLH E3 ligase ubiquitinates LDHA
Q96RQ3MCCC1HLCS biotinylates 6xMCCC1:6xMCCC2
Q9HCC0MCCC2HLCS biotinylates 6xMCCC1:6xMCCC2
P00414MT-CO3MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex
P00156MT-CYBIntermediate 0 binds heme and UQCC3
P00156MT-CYBMT-CYB is translated
P03891MT-ND2COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex
P03897MT-ND3COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex
P03905MT-ND4MT-ND4 is translated
P03905MT-ND4ND4, ND5 bind the 550kDa complex to form the 815kDa complex
P03905MT-ND4Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex
P03915MT-ND5ND4, ND5 bind the 550kDa complex to form the 815kDa complex
P03915MT-ND5Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex
O15239NDUFA1Intermediate 1 binds HP subcomplex to form Intermediate 2
Q86Y39NDUFA11Intermediate 1 binds HP subcomplex to form Intermediate 2
Q9UI09NDUFA12NDUF subunits bind to form the FP subcomplex
Q9UI09NDUFA12Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex
Q9P0J0NDUFA13HTRA2 binds NDUFA13 (GRIM-19)
Q9P0J0NDUFA13HTRA2 degrades NDUFA13 (GRIM-19)
Q9P0J0NDUFA13Intermediate 1 binds HP subcomplex to form Intermediate 2
O43678NDUFA2Intermediate 1 binds HP subcomplex to form Intermediate 2
O95167NDUFA3Intermediate 1 binds HP subcomplex to form Intermediate 2
Q16718NDUFA5Intermediate 1 binds HP subcomplex to form Intermediate 2
P56556NDUFA6Intermediate 1 binds HP subcomplex to form Intermediate 2
P51970NDUFA8Intermediate 1 binds HP subcomplex to form Intermediate 2
Q16795NDUFA9NDUF subunits bind to form the IP subcomplex
O14561NDUFAB1Intermediate 1 binds HP subcomplex to form Intermediate 2
O14561NDUFAB1LIPT2 transfers octanoyl group to GCSH
O14561NDUFAB1MCAT transfers Mal from Mal-CoA to NDUFAB1
O14561NDUFAB1MTRFR:MTRES1:39S ribosomal subunit:mRNA:peptidyl-tRNA:MALSU1:MIEF1:NDUFAB1 dissociates
O14561NDUFAB1Stalled 55S mitochondrial ribosome is dissociated to yield 28S subunit and 39S subunit:mRNA:peptidyl-tRNA:tRNA
O75438NDUFB1Intermediate 1 binds HP subcomplex to form Intermediate 2
O96000NDUFB10Intermediate 1 binds HP subcomplex to form Intermediate 2
O43676NDUFB3Intermediate 1 binds HP subcomplex to form Intermediate 2
O95168NDUFB4Intermediate 1 binds HP subcomplex to form Intermediate 2
O43674NDUFB5Intermediate 1 binds HP subcomplex to form Intermediate 2
O95139NDUFB6COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex
O95139NDUFB6The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex
P17568NDUFB7Intermediate 1 binds HP subcomplex to form Intermediate 2
O95169NDUFB8Intermediate 1 binds HP subcomplex to form Intermediate 2
Q9Y6M9NDUFB9Intermediate 1 binds HP subcomplex to form Intermediate 2
O43677NDUFC1Intermediate 1 binds HP subcomplex to form Intermediate 2
O95298NDUFC2Intermediate 1 binds HP subcomplex to form Intermediate 2
P28331NDUFS1NDUF subunits bind to form the FP subcomplex
O75489NDUFS3IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1
O75489NDUFS3NDUF subunits bind to form the IP subcomplex
O43181NDUFS4NDUF subunits bind to form the FP subcomplex
O43181NDUFS4Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex
O43920NDUFS5Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex
O43920NDUFS5The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I
O75380NDUFS6NDUF subunits bind to form the FP subcomplex
O75380NDUFS6Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex
O75251NDUFS7NDUF subunits bind to form the IP subcomplex
O00217NDUFS8NDUF subunits bind to form the IP subcomplex
P49821NDUFV1NDUF subunits bind to form the FP subcomplex
P49821NDUFV1NUBPL transfers 4Fe-4S to NDUFV1, V2
P19404NDUFV2NDUF subunits bind to form the FP subcomplex
P19404NDUFV2NUBPL transfers 4Fe-4S to NDUFV1, V2
P56181NDUFV3NDUF subunits bind to form the FP subcomplex
P56181NDUFV3Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex
P46459NSFATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane
P46459NSFATP hydrolysis by NSF disassembles the cis-SNARE at the TGN
P46459NSFcis-Golgi cis-SNARE binds NSF and SNAPs
P46459NSFcis-SNARE binds SNAPs and NSF hexamer at the TGN
P46459NSFNSF and SNAPs bind cis-SNARE at the ER membrane
P46459NSFNSF and SNAPs bind cis-SNARE complex
P46459NSFNSF and SNAPs bind the cis-SNARE at the Golgi
P46459NSFNSF ATPase activity dissociates cis-SNARE
P46459NSFNSF ATPase activity dissociates cis-SNARE at the ER
P46459NSFNSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN
P46459NSFSNAPs and NSF hexamer bind cis-SNARE at the TGN
P07237P4HBAutoproteolytic cleavage of Hh precursors
P07237P4HBERO1B oxidizes P4HB
P07237P4HBGPX7,8 catalyze peroxidation of P4HB (PDI)
P07237P4HBMTTP binds lomitapide
P07237P4HBP4HB binds Collagen chains
P07237P4HBP4HB forms mixed disulphides with Hh precursors
P07237P4HBP4HB mediates disulfide bond formation in Proinsulin
P07237P4HBP4HB:4-Hyp collagen propeptides dissociates
P07237P4HBProlyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines
P43034PAFAH1B1C2CD3 binds the mother centriole
P43034PAFAH1B1CDC42:GTP recruits DIAPH2-2 to kinetochores
P43034PAFAH1B1Dissociation of Phospho-Nlp from the centrosome
P43034PAFAH1B1Kinetochore capture of astral microtubules
P43034PAFAH1B1Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2
P43034PAFAH1B1Loss of C-Nap-1 from centrosomes
P43034PAFAH1B1Mad1 binds kinetochore
P43034PAFAH1B1RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex
P43034PAFAH1B1Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
P43034PAFAH1B1Recruitment of CDK11p58 to the centrosomes
P43034PAFAH1B1Recruitment of Plk1 to centrosomes
P16499PDE6AG alpha t2 binds and activates PDE6
P16499PDE6AGNAT1-GTP binds PDE6 and activates it
P16499PDE6AGNAT1-GTP hydrolyses its bound GTP to GDP
P35913PDE6BG alpha t2 binds and activates PDE6
P35913PDE6BGNAT1-GTP binds PDE6 and activates it
P35913PDE6BGNAT1-GTP hydrolyses its bound GTP to GDP
O43924PDE6DARL13B binds INPP5E
O43924PDE6DARL2:GTP bind PDE6D on KRAS4B
O43924PDE6DDeltarasin binds PDE6D
O43924PDE6DINPP5E translocates to the primary cilium
O43924PDE6DKRAS4B recycles to the plasma membrane
O43924PDE6DPDE6D binds INPP5E
O43924PDE6DPDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+
O43924PDE6DPDE6D dissociates from ARL13B:INPP5E
P18545PDE6GG alpha t2 binds and activates PDE6
P18545PDE6GGNAT1-GTP binds PDE6 and activates it
P18545PDE6GGNAT1-GTP hydrolyses its bound GTP to GDP
P42336PIK3CAActivated cytosolic FGFR1 fusions bind PIK3CA
P42336PIK3CAActivated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
P42336PIK3CAActivated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
P42336PIK3CAActivated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
P42336PIK3CAActivated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
P42336PIK3CAActivated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
P42336PIK3CAActivated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
P42336PIK3CAActivated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
P42336PIK3CAActivated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
P42336PIK3CAActivated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
P42336PIK3CAActivated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
P42336PIK3CAActivated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
P42336PIK3CAActivated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
P42336PIK3CAActivated NTRK2 recruits PI3K
P42336PIK3CAActivated NTRK3 binds PI3K
P42336PIK3CAActive FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
P42336PIK3CAActive FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
P42336PIK3CAALK mutants bind PI3KCA
P42336PIK3CABCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA
P42336PIK3CABinding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
P42336PIK3CABinding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants
P42336PIK3CABinding of PI3K to complex of GRB2:GAB1 and p-EGFRvIII
P42336PIK3CABinding of PI3K to ERBB2:p-ERBB3 heterodimer
P42336PIK3CABinding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
P42336PIK3CADirect recruitment of PI3K to p-KIT
P42336PIK3CAFLT3 fusions recruit PIK3CA through PIK3R1
P42336PIK3CAFLT3 mutants recruit PIK3CA through PIK3R1
P42336PIK3CAG alpha (q) inhibits PI3K alpha
P42336PIK3CAIndirect recruitment of PI3K to KIT via p(Y)-GAB2
P42336PIK3CAPI3K binds membrane-associated estrogen receptors
P42336PIK3CAPI3K binds to EGF:EGFR:GRB2:GAB1Inositol phosphate
P42336PIK3CARAC1,RAC2,RHOG activate PI3K
P42338PIK3CBGPVI stimulates PI3K beta, gamma
O00329PIK3CDp-CD19:VAV binds PI3K and GRB2
O00329PIK3CDp-PIK3AP1 (p-BCAP) binds PIK3CD:PIK3R1 (PI3K delta)
P48736PIK3CGGbeta:gamma recruits PI3K gamma
P48736PIK3CGGPVI stimulates PI3K beta, gamma
P27986PIK3R1Activated cytosolic FGFR1 fusions bind PIK3CA
P27986PIK3R1Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
P27986PIK3R1Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1
P27986PIK3R1Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
P27986PIK3R1Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
P27986PIK3R1Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
P27986PIK3R1Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
P27986PIK3R1Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
P27986PIK3R1Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1
P27986PIK3R1Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
P27986PIK3R1Activated FGFR4 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
P27986PIK3R1Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1
P27986PIK3R1Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
P27986PIK3R1Activated NTRK2 recruits PI3K
P27986PIK3R1Activated NTRK3 binds PI3K
P27986PIK3R1Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
P27986PIK3R1Active FLT3:GRB2:p-Y-GAB2 binds PIK3R1
P27986PIK3R1Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
P27986PIK3R1Active FLT3:p-Y-GRB10 binds PIK3R1
P27986PIK3R1ALK mutants bind PI3KCA
P27986PIK3R1ALK mutants bind PI3KR1
P27986PIK3R1BCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA
P27986PIK3R1BCR-FGFR1:GRB2:p-GAB2 binds PIK3R1
P27986PIK3R1Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
P27986PIK3R1Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants
P27986PIK3R1Binding of PI3K to complex of GRB2:GAB1 and p-EGFRvIII
P27986PIK3R1Binding of PI3K to ERBB2:p-ERBB3 heterodimer
P27986PIK3R1Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
P27986PIK3R1Binding of PIK3 regulatory alpha subunit to GRB2:GAB1Inositol phosphate
P27986PIK3R1Cytosolic FGFR1 fusion proteins bind PIK3R1
P27986PIK3R1FLT3 fusions recruit PIK3CA through PIK3R1
P27986PIK3R1FLT3 mutants recruit PIK3CA through PIK3R1
P27986PIK3R1GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K
P27986PIK3R1p-CD19:VAV binds PI3K and GRB2
P27986PIK3R1p-PIK3AP1 (p-BCAP) binds PIK3CD:PIK3R1 (PI3K delta)
P27986PIK3R1PI3K binds to EGF:EGFR:GRB2:GAB1Inositol phosphate
P31040SDHAFAD attaches to SDHA
P31040SDHASDHA binds to SDHB
P31040SDHASDHA:SDHB binds to SDHC:SDHD
P31040SDHASDHAF4 binds to FAD-SDHA
P21912SDHBSDHA binds to SDHB
P21912SDHBTransfer of Fe-S clusters to SDHB
Q99643SDHCSDHA:SDHB binds to SDHC:SDHD
O14521SDHDSDHA:SDHB binds to SDHC:SDHD
Q9UDW1UQCR10Late core complex dimer binds UQCR10, UQCR11, UQCRFS1.
O14957UQCR11Late core complex dimer binds UQCR10, UQCR11, UQCRFS1.
P14927UQCRBIntermediate I binds second heme, UQCRB, UQCRQ
P14927UQCRBIntermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH
P14927UQCRBLate core complex dimerizes
P31930UQCRC1Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH
P31930UQCRC1Late core complex dimerizes
P22695UQCRC2Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH
P22695UQCRC2Late core complex dimerizes
P47985UQCRFS12Fe-2S is inserted in UQCRFS1
P47985UQCRFS1apo-UQCRFS1 binds LYRM7
P47985UQCRFS1Late core complex dimer binds UQCR10, UQCR11, UQCRFS1.
O14949UQCRQIntermediate I binds second heme, UQCRB, UQCRQ
O14949UQCRQIntermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH
O14949UQCRQLate core complex dimerizes

Table 2c. Gene expression signalling processes & Recon2 compounds-catalysers

UniProtHGNCReactome processesMRegAtlas
Q13085ACACAExpression of Acetyl CoA Carboxylase 1 (ACACA, ACC1)
O00763ACACBExpression of Acetyl CoA Carboxylase 2 (ACACB, ACC2)
P11310ACADMExpression of ACADM
P49748ACADVLExpression of ACADVL
Q15067ACOX1Expression of ACOX1
P06576ATP5F1BExpression of ATP5B
Q99437ATP6V0BMITF-M-dependent ATP6V0B gene expression
P27449ATP6V0CMITF-M-dependent ATP6V0C gene expression
P61421ATP6V0D1Expression of ATP6VOD1
P61421ATP6V0D1MITF-M-dependent ATP6V0D1 gene expression
O15342ATP6V0E1MITF-M-dependent ATP6V0E1 gene expression
P38606ATP6V1AMITF-M-dependent ATP6V1A gene expression
P21281ATP6V1B2MITF-M-dependent ATP6V1B2 gene expression
P21283ATP6V1C1MITF-M-dependent ATP6V1C1 gene expression
P36543ATP6V1E1MITF-M-dependent ATP6V1E1 gene expression
O75348ATP6V1G1MITF-M-dependent ATP6V1G1gene expression
Q9UI12ATP6V1HMITF-M-dependent ATP6V1H gene expression
P24310COX7A1COX7A1 gene expression is stimulated by EBF2
P48506GCLCAcK-NFE2L2-dependent GCLC gene expression
P48507GCLMAcK-NFE2L2-dependent GCLM gene expression
P31350RRM2RRM2 gene expression is stimulated by E2F1 and inhibited by E2F6
Q9UPY5SLC7A11AcK-NFE2L2-dependent SLC7A11 expression