Regulation of triacylglycerol hydrolysis

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Description

Hormone-sensitive lipase (HSL) is a major enzyme involved in triacylglycerol lipolysis, and its activity is controlled by phosphorylation in response to adrenergic and intracellular effectors in skeletal muscle and adipose tissue. Lipolysis is the hydrolysis of triacylglycerol to release fatty acids and glycerol as energy substrates. Fatty acids derived from adipose tissue are an important energy source for use by other organs, such as liver, skeletal muscle, kidney and myocardium.

References

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Contributors

Tatiana Serebriyskaya1, Valeriya Berzhitskaya1, John Albanese2

Affiliations
  1. 1Systems Biology and Translational Medicine, EPAM Systems, Inc., Newtown, USA
  2. 2University of Connecticut School of Medicine, Farmington, USA