Regulation of glutaminolysis via the NF-kB-PKCe axis in lung cancer cells

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Description

Glutaminase C (GAC) catalyses the conversion of glutamine to glutamate. Glutamate then enters the tricarboxylic acid cycle. High availability of glutamate is important for tumor cells to satisfy their increased need for energy and synthesis of macromolecules.

References

  1. Altman BJ, Stine ZE, Dang CV. From Krebs to clinic: glutamine metabolism to cancer therapy. Nat Rev Cancer. 2016 Oct;16(10):619-34. doi: 10.1038/nrc.2016.71. PMID: 27492215.
  2. Cassago A, Ferreira AP, Ferreira IM, Fornezari C, Gomes ER, Greene KS, Pereira HM, Garratt RC, Dias SM, Ambrosio AL. Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism. Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1092-7. doi: 10.1073/pnas.1112495109. PMID: 22228304.
  3. Han T, Zhan W, Gan M, Liu F, Yu B, Chin YE, Wang JB. Phosphorylation of glutaminase by PKCε is essential for its enzymatic activity and critically contributes to tumorigenesis. Cell Res. 2018 Jun;28(6):655-669. doi: 10.1038/s41422-018-0021-y. PMID: 29515166.
  4. Wang JB, Erickson JW, Fuji R, Ramachandran S, Gao P, Dinavahi R, Wilson KF, Ambrosio AL, Dias SM, Dang CV, Cerione RA. Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell. 2010 Sep 14;18(3):207-19. doi: 10.1016/j.ccr.2010.08.009. PMID: 20832749.

Contributors

Hanna Borlinghaus1, Falk Schreiber1,2, Maria del Carmen Heredia3

Affiliations
  1. 1University of Konstanz, Konstanz, Germany
  2. 2Faculty of Information Technology, Monash University, Clayton, Australia
  3. 3University of Connecticut School of Medicine, Farmington, USA