Regulation of glutaminolysis via the NF-kB-PKCe axis in lung cancer cells

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Contributors

Hanna Borlinghaus, Falk Schreiber, Maria Heredia Chavez

Description

Glutaminase C (GAC) catalyses the conversion of glutamine to glutamate. Glutamate then enters the tricarboxylic cycle. High availability of glutamate is important for tumor cells to satisfy their increased need for energy and synthesis of macromolecules.

References

  1. Han T, Zhan W, Gan M, Liu F, Yu B, Chin YE, Wang JB. Phosphorylation of glutaminase by PKCε is essential for its enzymatic activity and critically contributes to tumorigenesis. Cell Res. 2018 Jun;28(6):655-669. doi: 10.1038/s41422-018-0021-y. PMID: 29515166.
  2. Ryu JM, Lee SH, Seong JK, Han HJ. Glutamine contributes to maintenance of mouse embryonic stem cell self-renewal through PKC-dependent downregulation of HDAC1 and DNMT1/3a. Cell Cycle. 2015;14(20):3292-305. doi: 10.1080/15384101.2015.1087620. PMID: 26375799.