Regulation of glycogen metabolism, muscle

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Regulation of glycogen metabolism, liver

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Contributors

Vasundra Touré, Luiz Ladeira, Tatiana Serebriyskaya, Valeriya Berzhitskaya, Alexander Mazein, John Albanese

Description

Intracellular glycogen stores are used to maintain blood-glucose homeostasis during fasting and as a source of energy for muscle contraction, as well as used to support a broad range of cellular activities in most tissues. Glycogen phosphorylases (liver, muscle and brain forms, PYGL, PYGM and PYGB) catalyse the breakdown of glycogen to glucose-1-phosphate for glycolysis to support these cellular requirements.

References

  1. Reactome: Glycogen metabolism. Id: R-HSA-8982491. Release 84. Accessed 15 May 2023
  2. Reactome: Glucagon signalling in metabolic regulation. Integration of energy metabolism. Id: R-HSA-163685. Release 84. Accessed 15 May 2023
  3. KEGG: Glucagon signaling pathway. Id: hsa04922. Accessed 15 May 2023
  4. MetaCore: Glycogen metabolism. Id: 919. Accessed 15 May 2023
  5. Adeva-Andany MM, González-Lucán M, Donapetry-García C, Fernández-Fernández C, Ameneiros-Rodríguez E. Glycogen metabolism in humans. BBA Clin. 2016 Feb 27;5:85-100. Review. PMID: 27051594
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  7. Brushia RJ, Walsh DA. Phosphorylase kinase: the complexity of its regulation is reflected in the complexity of its structure. Front Biosci. 1999 Sep 15;4:D618-41. PMID: 10487978
  8. Newgard CB, Hwang PK, Fletterick RJ. The family of glycogen phosphorylases: structure and function. Crit Rev Biochem Mol Biol. 1989;24(1):69-99. PMID: 2667896