Regulation of glycolysis, cardiac muscle

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Description

This diagram represents cardiac muscle. PFKFB2, PFKM and FBP2 reflect the cardiac/muscle context. FBP2 is used instead of the liver-associated FBP1. ADCY5 and ADCY6 represent major cardiac adenylyl cyclases. Other isoforms are relevant in other tissues, including ADCY9 in skeletal muscle. PKA has alternative catalytic (PRKACA/PRKACB) and regulatory (PRKAR1A/B, PRKAR2A/B) subunits. PRKACA and PRKAR2A are used here as a specific cardiac example.

References

  1. Deprez J, Vertommen D, Alessi DR, Hue L, Rider MH. Phosphorylation and activation of heart 6-phosphofructo-2-kinase by protein kinase B and other protein kinases of the insulin signaling cascades. J Biol Chem. 1997 Jul 11;272(28):17269-75. doi: 10.1074/jbc.272.28.17269. PMID: 9211863.
  2. MetaCore: Glycolysis and gluconeogenesis (short map). MetaCore:930.
  3. Reactome: DAG and IP3 signaling. Reactome:R-HSA-1489509.
  4. Reactome: Glucagon signaling in metabolic regulation. Reactome:R-HSA-163359.
  5. Rider MH, Bertrand L, Vertommen D, Michels PA, Rousseau GG, Hue L. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis. Biochem J. 2004 Aug 1;381(Pt 3):561-79. doi: 10.1042/BJ20040752. PMID: 15170386.
  6. Rider MH, van Damme J, Vertommen D, Michel A, Vandekerckhove J, Hue L. Evidence for new phosphorylation sites for protein kinase C and cyclic AMP-dependent protein kinase in bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. FEBS Lett. 1992 Sep 28;310(2):139-42. doi: 10.1016/0014-5793(92)81315-D. PMID: 1327869.

Contributors

Alexander Mazein1,2, Vasundra Touré3,4, Maria del Carmen Heredia5

Affiliations
  1. 1Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg
  2. 2Department of Cancer Research, Luxembourg Institute of Health, Strassen, Luxembourg
  3. 3Norwegian University of Science and Technology, Trondheim, Norway
  4. 4SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland
  5. 5University of Connecticut School of Medicine, Farmington, USA