Regulation of pyrimidine biosynthesis via MAPK signalling

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Hanna Borlinghaus, Falk Schreiber, John Albanese (annotation)


The activation of de novo pyrimidine biosynthesis is a requirement for cell proliferation in tumor tissues. The carbamoyl phosphate synthetase (CPSase) catalyses the rate-limiting step of the synthetic pathway. CPSase refers to one catalytic activity of the multifunctional protein CAD that catalyses the first three steps of the pathway.


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