Regulation of cholesterol metabolism via SREBP

Downloads:   GraphML   SBGN-ML   CellDesigner   MINERVA   Newt  

Contributors

Tatiana Serebriyskaya, Valeriya Berzhitskaya, Maria Heredia Chavez (Annotation)

Description

Cholesterol biosynthesis and uptake are tightly regulated at the transcriptional level through a negative feedback control. The transcription factor family known as sterol regulatory element-binding proteins (SREBPs) is in charge of this feedback control. In particular, SREBP2 is activated in a cholesterol-dependent manner, and hence is deeply involved in regulation of the expression of genes closely related to cholesterol metabolism.

References

  1. Mazein A, Watterson S, Gibbs H, Hsieh W, Abdullah M Ba, Blanc M, Griffiths WJ, Freeman TC, Ghazal P. Regulation and feedback of cholesterol metabolism. 2011. doi:10.1038/npre.2011.6315.1
  2. Shimano H, Sato R. SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology. Nat Rev Endocrinol. 2017 Dec;13(12):710-730. doi:10.1038/nrendo.2017.91. Epub 2017 Aug 29. Review. PMID: 28849786
  3. Sato R. Arch Biochem Biophys. Sterol metabolism and SREBP activation.2010 Sep 15;501(2):177-81. PMID: 20541520
  4. Bengoechea-Alonso MT, Ericsson J. SREBP in signal transduction: cholesterol metabolism and beyond.Curr Opin Cell Biol. 2007 Apr;19(2):215-22. PMID: 17303406
  5. Lee SJ, Sekimoto T, Yamashita E, Nagoshi E, Nakagawa A, Imamoto N, Yoshimura M, Sakai H, Chong KT, Tsukihara T, Yoneda Y. The structure of importin-beta bound to SREBP-2: nuclear import of a transcription factor. Science. 2003 Nov 28;302(5650):1571-5. PMID: 14645851