Regulation of cholesterol metabolism via SREBP

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Tatiana Serebriyskaya, Valeriya Berzhitskaya, Maria Heredia Chavez (Annotation)


Cholesterol biosynthesis and uptake are tightly regulated at the transcriptional level through a negative feedback control. The transcription factor family known as sterol regulatory element-binding proteins (SREBPs) is in charge of this feedback control. In particular, SREBP2 is activated in a cholesterol-dependent manner, and hence is deeply involved in regulation of the expression of genes closely related to cholesterol metabolism.


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