Regulation of cholesterol metabolism via SREBP

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Description

Cholesterol biosynthesis and uptake are tightly regulated at the transcriptional level through negative feedback. The transcription factor family known as sterol regulatory element-binding proteins (SREBPs) is in charge of this feedback control. In particular, SREBP2 is activated in a cholesterol-dependent manner, and hence is deeply involved in regulation of the expression of genes closely related to cholesterol metabolism.

References

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Contributors

Tatiana Serebriyskaya1, Valeriya Berzhitskaya1, Maria del Carmen Heredia2

Affiliations
  1. 1Systems Biology and Translational Medicine, EPAM Systems, Inc., Newtown, USA
  2. 2University of Connecticut School of Medicine, Farmington, USA