Reactome-Recon List 1

These tables contain proteins from the Human Metabolic Reconstruction Recon2 that match those in Reactome pathways and participate in signalling processes, the cases when a protein connected to a process via production or consumption arcs. Table 1a includes phosphorylation processes, while Tables 1b and 1c include other types of processes. The MRegAtlas column links a protein-process pair to the map that draws that process.

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Table 1a. Signalling phosphorylation processes & Recon2 catalysers

UniProt	HGNC	Reactome processes	MRegAtlas
O95477	ABCA1	PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer
P09917	ALOX5	ALOX5 is phosphorylated by MAPKAP2
Q9NYG5	ANAPC11	Free APC/C phosphorylated by Cyclin B:Cdc2
Q9NYG5	ANAPC11	Free APC/C phosphorylated by Plk1
Q9Y5P4	CERT1	CSNK1G2 phosphorylates p-CERT1-2
Q9Y5P4	CERT1	PPM1L dephosphorylates multiphospho-CERT1-2
Q9Y5P4	CERT1	PRKD1,2,3 phosphorylates CERT1-2
P11182	DBT	BCKDK phosphorylates BCKDH	BCAA
P11182	DBT	PPM1K dephosphorylates p-BCKDH	BCAA
P00533	EGFR	CBL binds and ubiquitinates phosphorylated Sprouty
P00533	EGFR	EGFR autophosphorylation	Inositol phosphate
P00533	EGFR	GRB2:GAB1 binds to phosphorylated EGFR
P00533	EGFR	Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor
P00533	EGFR	Phosphorylation of CBL (EGFR:CBL)
P00533	EGFR	Phosphorylation of CBL (EGFR:GRB2:CBL)
P00533	EGFR	Phosphorylation of EGFR by SRC kinase
P00533	EGFR	SHC1 binds to the phosphorylated EGF receptor:ligand complex
P48163	ME1	NEK1 phosphorylates ME1
P48163	ME1	PGAM5 dodecamer dephosphorylates p-S336-ME1
P29474	NOS3	p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179
P29474	NOS3	Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177	eNOS
P29474	NOS3	PKA phosphorylates NOS3 (eNOS) on serine-633
Q13370	PDE3B	p-T309,S474-AKT2:PIP3 phosphorylates PDE3B	cAMP
Q07343	PDE4B	PKA phosphorylates PDE4B
P16118	PFKFB1	PKA tetramer:cAMP phosphorylates PF2K-Pase
P16118	PFKFB1	PP2A complex dephosphorylates pPFKFB1
Q8NEB9	PIK3C3	ULK1 phosphorylates Beclin-1
P42336	PIK3CA	Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
P42336	PIK3CA	Phosphorylated GAB1 recruits PI3K to MET
P42336	PIK3CA	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K
P42336	PIK3CA	Phosphorylated heterodimers of ERBB2 KD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K
P42336	PIK3CA	Phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 bind PI3K
P42336	PIK3CA	Phosphorylated KIT mutants bind PI3K
O14986	PIP5K1B	Phosphorylated DVL recruits PIP5K1B to the plasma membrane
P47712	PLA2G4A	Phosphorylation of cPLA2 by ERK-2	Eicosanoids
P47712	PLA2G4A	Phosphorylation of cPLA2 by MAPK p38 alpha
P19174	PLCG1	Activated FGFR1 mutants and fusions phosphorylate PLCG1
P19174	PLCG1	Activated FGFR1 phosphorylates PLCG1
P19174	PLCG1	Activated FGFR2 mutants phosphorylate PLCG1
P19174	PLCG1	Activated FGFR2 phosphorylates PLCG1
P19174	PLCG1	Activated FGFR3 phosphorylates PLCG1
P19174	PLCG1	Activated FGFR3 point and translocation mutants phosphorylate PLCG1
P19174	PLCG1	Activated FGFR4 mutants phosphorylate PLCG1
P19174	PLCG1	Activated FGFR4 phosphorylates PLCG1
P19174	PLCG1	Active ALK phosphorylates PLCG1
P19174	PLCG1	ALK fusions phosphorylate PLCG1
P19174	PLCG1	Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant
P19174	PLCG1	Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants
P19174	PLCG1	EGFR activates PLC-gamma1 by phosphorylation
P19174	PLCG1	NTRK2 phosphorylates PLCG1
P19174	PLCG1	NTRK3 phosphorylates PLCG1
P19174	PLCG1	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind PLCG1
P19174	PLCG1	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1
P19174	PLCG1	Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind PLCG1
P19174	PLCG1	Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1
P19174	PLCG1	Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind PLCG1
P19174	PLCG1	Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1
P19174	PLCG1	Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant
P19174	PLCG1	Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants
P19174	PLCG1	Phosphorylation of PLCgamma by Netrin-1
P19174	PLCG1	Phosphorylation of PLCgamma by PDGFR
P19174	PLCG1	PLCG1 phosphorylation by p-EGFR:p-ERBB2
P19174	PLCG1	SFKs phosphorylate PLCG1
P19174	PLCG1	TrkA phosphorylates PLCG1
P16885	PLCG2	1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG
P16885	PLCG2	Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1
P16885	PLCG2	SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2
Q06830	PRDX1	CDK5:p25 phosphorylates PRDX1
P32119	PRDX2	CDK5:p25 phosphorylates PRDX2
P60484	PTEN	Casein kinase II phosphorylates PTEN
P60484	PTEN	FRK phosphorylates PTEN
Q15185	PTGES3	Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3
Q03393	PTS	PTPS is phosphorylated by cGMP-dependant protein kinase II
P11216	PYGB	glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP
P06737	PYGL	glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP	Glycogen
P11217	PYGM	glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP	Glycogen
Q8N697	SLC15A4	Activated IKBKB phosphorylates IRF5
Q8N697	SLC15A4	TASL is phosphorylated
P35270	SPR	Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II

Table 1b. Other signalling processes & Recon2 catalysers

UniProt	HGNC	Reactome processes	MRegAtlas
O95477	ABCA1	4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane
O95477	ABCA1	4xPALM-C-p-2S-ABCA1 tetramer binds APOA1
O95477	ABCA1	ABCA1 mRNA is translated
O95477	ABCA1	NR1H2 binds ABCA1
O95477	ABCA1	ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer
P09110	ACAA1	TYSND1 cleaves ACAA1
O00763	ACACB	HLCS biotinylates ACACB
O00763	ACACB	Transcriptional activation of ACACB by ChREBP:MLX
Q9H845	ACAD9	COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex
Q9H845	ACAD9	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I
P12821	ACE	ACEIs bind ACE
Q9BYF1	ACE2	ACE2 is glycosylated to glycosylated-ACE2
Q9BYF1	ACE2	Cleavage of S protein into S1:S2
Q9BYF1	ACE2	Cleavage of S protein into S1:S2
Q9BYF1	ACE2	Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid
Q9BYF1	ACE2	Endocytosis of SARS-CoV-1 Virion
Q9BYF1	ACE2	Endocytosis of SARS-CoV-2 Virion
Q9BYF1	ACE2	FURIN Mediated SARS-CoV-2 Spike Protein Cleavage
Q9BYF1	ACE2	FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis
Q9BYF1	ACE2	glycosylated-ACE2 binds ACE2 inhibitors
Q9BYF1	ACE2	S1,S2 Dissociate from S1:ACE2:S2
Q9BYF1	ACE2	Spike glycoprotein of SARS coronavirus binds ACE2 on host cell
Q9BYF1	ACE2	Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell
Q9BYF1	ACE2	TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis
Q9BYF1	ACE2	TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis
Q9BYF1	ACE2	Viral Spike Binds to ACE2 on Uninfected Cell
P22303	ACHE	ACHEIs bind ACHE
P53396	ACLY	ACLY tetramer binds ETC-1002-CoA
P53396	ACLY	Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX
P21399	ACO1	ACO1 binds 4Fe-4S
Q99798	ACO2	Frataxin transfers Fe2+ to ACO2
Q99798	ACO2	ROS,RNS oxidize ACO2:4Fe-4S
Q15067	ACOX1	TYSND1 cleaves ACOX1
O60266	ADCY3	GNAL:GTP (G alpha-olf) binds ADCY3
Q99943	AGPAT1	Transcriptional activation of AGPAT1 by ChREBP:MLX
O00116	AGPS	TYSND1 cleaves AGPS
O43865	AHCYL1	AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it
Q9GZX7	AICDA	AICDA binds immunoglobulin gene variable region
Q9GZX7	AICDA	AICDA translocates from the cytosol to the nucleus
P13716	ALAD	ALAD binds to Pb2+
Q9NYG5	ANAPC11	Association of Cdh1 with the APC/C
Q9NYG5	ANAPC11	Binding of the MCC complex to the APC/C complex
Q9NYG5	ANAPC11	Degradation of multiubiquitinated Cdh1
Q9NYG5	ANAPC11	Dissociation of Cdc20 from APC/C complex
Q9NYG5	ANAPC11	Dissociation of phospho-Cdh1 from the APC/C complex
P15289	ARSA	M6PR transports activated ARSA to the lysosome
P23634	ATP2B4	ATP2B4 binds to NOS1, inhibiting it	nNOS
P15291	B4GALT1	Association of ADAM and B4GALT1 With ZP3
P15291	B4GALT1	B4GALT1 binds LALBA
P21964	COMT	COMT binds COMT Inhibitors
O00483	COXFA4	MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex
P31327	CPS1	SIRT5 deglutarylates CPS1	Urea cycle
P31327	CPS1	SIRT5 desuccinylates CPS1	Urea cycle
P08574	CYC1	Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH
P05108	CYP11A1	CYP11A1 cleaves 20a,22b-DHCHOL	Estradiol
P11511	CYP19A1	CYP19A1 binds Aromatase inhibitors
P08684	CYP3A4	CYP3A4 binds CYP3A4 inhibitors
P11182	DBT	DLD dimer dehydrogenates dihydrolipoyl
P00374	DHFR	DHFR dimer binds DHFR inhibitors
Q02127	DHODH	DHODH:FMN binds DHODH inhibitors
P10515	DLAT	DLAT trimer transfers acetyl to CoA
P10515	DLAT	DLD dimer dehydrogenates dihydrolipoyl
P10515	DLAT	LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT
P10515	DLAT	PDH E1 decarboxylates PYR, transferring acetyl to DLAT
P10515	DLAT	SIRT4 cleaves lipoyl from DLAT
P26358	DNMT1	AcK685 p-Y705, S727 STAT3 dimer and DNMT1 bind IL2RG gene
P26358	DNMT1	Nucleolar Remodelling Complex (NoRC) binds intergenic region of rDNA
P26358	DNMT1	STAT3, DNMT1 and HDAC1 bind PTPN6 gene
P26358	DNMT1	SUMOyation of DNMT1 with SUMO1
P26358	DNMT1	Translation of DNMT1 mRNA is repressed by miR-21
P26358	DNMT1	UHRF1:Chromatin binds DNMT1
Q9Y6K1	DNMT3A	CBX4 (Pc2) SUMOylates DNMT3A with SUMO1
Q9Y6K1	DNMT3A	DNMT3A binds Me2sR4-HIST1H4
Q9Y6K1	DNMT3A	DNMT3A:DNMT3L binds chromatin
Q9Y6K1	DNMT3A	PIWIL4:piRNA binds nascent LINE1 pre-RNA and recruits SPOCD1, C19ORF84, DNMT3A, DNMT3L, the NURD complex, and the BAF complex
Q9UBC3	DNMT3B	DNMT3B:DNMT3L binds chromatin
Q9UBC3	DNMT3B	Nucleolar Remodelling Complex (NoRC) binds intergenic region of rDNA
Q9UBC3	DNMT3B	SUMOylation of DNMT3B with SUMO1
Q16555	DPYSL2	Interaction of NUMB with L1
P00533	EGFR	AAMP binds EGFR
P00533	EGFR	Active PLC-gamma1 dissociates from EGFR
P00533	EGFR	Assembly of EGFR complex in clathrin-coated vesicles
P00533	EGFR	Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85
P00533	EGFR	Binding of CBL to EGFR
P00533	EGFR	CBL-mediated ubiquitination of CIN85
P00533	EGFR	EGFR binds EGF ligand	Inositol phosphate
P00533	EGFR	EGFR binds EPS15, EPN1, EPS15L1
P00533	EGFR	EGFR dimerization	Inositol phosphate
P00533	EGFR	EGFR non-clathrin mediated endocytosis
P00533	EGFR	EGFRvIII mutant binds chaperone proteins HSP90 and CDC37
P00533	EGFR	ERBB2 ECD mutants heterodimerize with EGFR
P00533	EGFR	ERBB4 forms heterodimers with EGFR
P00533	EGFR	FAM83B, (FAM83A, FAM83D) bind EGFR
P00533	EGFR	GRB2:SOS1 complex binds to EGF:EGFR complex
P00533	EGFR	HBEGF-bound EGFR forms a heterodimer with GPNMB
P00533	EGFR	Inactivation of over-expressed wild type EGFR by Cetuximab recombinant antibody
P00533	EGFR	L1-EGFR trans-heterodimerization
P00533	EGFR	Ligand-independent dimerization of EGFRvIII mutant
P00533	EGFR	Localization of CBL:GRB2 to the membrane
P00533	EGFR	Phospholipase C-gamma1 binds to the activated EGF receptor
P00533	EGFR	PTK2 binds activated EGFR
P00533	EGFR	Ubiquitination of stimulated EGFR (CBL)
P00533	EGFR	Ubiquitination of stimulated EGFR (CBL:GRB2)
Q9H9B1	EHMT1	Cdh1:APC/C complex binds EHMT1:EHMT2
Q9H9B1	EHMT1	EHMT1:EHMT2 complex binds E2F6.com-1 core
Q96KQ7	EHMT2	Cdh1:APC/C complex binds EHMT1:EHMT2
Q96KQ7	EHMT2	EHMT1:EHMT2 complex binds E2F6.com-1 core
Q96KQ7	EHMT2	Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene
P07148	FABP1	FABP1 transports fatty acids into the nucleus
P07148	FABP1	Fatty acid ligands activate PPARA
P49327	FASN	Formation of fatty acid synthase (FAS) dimer
P49327	FASN	NS3 binds FASN dimer
P49327	FASN	OLAH hydrolyzes decanoyl-FASN dimer to DECA and FASN dimer
P49327	FASN	Phosphopantetheine conjugation of the ACP domain of FAS
P49327	FASN	Transcriptional activation of FASN monomer gene by ChREBP:MLX
P35557	GCK	cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP)
P35557	GCK	glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex
P35557	GCK	NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein
P35557	GCK	NPC exports GCK1 from nucleus
P35557	GCK	NPC transports GCK1:GCKR from cytosol to nucleoplasm
P35557	GCK	nucleoplasmic GCK1:GCKR complex => glucokinase (GCK1) + glucokinase regulatory protein (GCKR)
P35754	GLRX	glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized)
P35754	GLRX	RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)
P35754	GLRX	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)
Q9UI32	GLS2	TP53 stimulates GLS2 transcription
P25092	GUCY2C	GUCY2C trimer binds GUCA2A,B
P25092	GUCY2C	GUCY2C trimer binds sta1
P09601	HMOX1	HM13 cleaves HMOX1 dimer
P09601	HMOX1	HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane
P09601	HMOX1	HMOX1 gene produces HMOX1 dimer
P09601	HMOX1	HMOX1 translocates from the cytosol to the nucleoplasm
P51659	HSD17B4	TYSND1 cleaves HSD17B4
P48735	IDH2	ACAT1 tetramer acetylates IDH2 dimer
P48735	IDH2	SIRT3 deacetylates AcK-IDH2 dimer
Q13123	IK	Formation of the Spliceosomal B complex
Q13123	IK	Formation of the Spliceosomal Bact complex
Q13123	IK	Formation of the Spliceosomal Pre-B complex
Q92835	INPP5D	Interaction of PECAM-1 and SHIP
Q92835	INPP5D	PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated
Q9NRR6	INPP5E	ARL13B binds INPP5E
Q9NRR6	INPP5E	INPP5E translocates to the primary cilium
Q9NRR6	INPP5E	PDE6D binds INPP5E
Q9NRR6	INPP5E	PDE6D dissociates from ARL13B:INPP5E
O15357	INPPL1	PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated
P48200	IREB2	SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2
Q8NEZ4	KMT2C	Formation of the MLL3 complex
Q8NEZ4	KMT2C	PAXIP1:PAGR1 complex, NCOA6 and KDM6A bind MLL3 complex
Q9NQR1	KMT5A	TWIST1 recruits SETD8 to CDH1 gene promoter
Q9NQR1	KMT5A	ZEB1 recruits SETD8 to CDH1 gene promoter
P04180	LCAT	LCAT + discoidal HDL <=> LCAT:discoidal HDL complex
P04180	LCAT	LCAT + spherical HDL <=> LCAT:spherical HDL complex
P04180	LCAT	LCAT:discoidal HDL complex <=> LCAT + discoidal HDL
P04180	LCAT	LCAT:spherical HDL complex <=> LCAT + spherical HDL
P00338	LDHA	CTLH E3 ligase ubiquitinates LDHA
P11150	LIPC	LIPC dimer binds heparin
P11150	LIPC	LMF1,2 bind LIPC dimer
P11150	LIPC	LMF1,2 transport LIPC dimer from ER lumen to extracellular region
P06858	LPL	HSPG binds LPL dimer
P06858	LPL	PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer
P06858	LPL	PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer
P21397	MAOA	MAOA inhibitors bind MAOA:FAD
P27338	MAOB	MAOB inhibitors bind MAOB:FAD
Q96RQ3	MCCC1	HLCS biotinylates 6xMCCC1:6xMCCC2
Q9HCC0	MCCC2	HLCS biotinylates 6xMCCC1:6xMCCC2
P48163	ME1	ME1 tetramerizes
Q5JRA6	MIA3	MIA2 and MIA3 dissociate from procollagen VII vesicle
Q5JRA6	MIA3	MIA2 and MIA3 load procollagen VII into COPII vesicles
Q5JRA6	MIA3	MIA3 binds procollagen VII
P25325	MPST	MPST and TXN2 enable the synthesis of disulfanide from CysS248-MPST
P25325	MPST	MPST transfers sulfur atom from 3MPYR to form CysS248-MPST
Q13614	MTMR2	MTMR12 binds MTMR2
Q13614	MTMR2	MTMR2 binds MTMR10
Q13614	MTMR2	MTMR2 binds SBF2
Q13614	MTMR2	MTMR2 dimerizes
Q13614	MTMR2	SBF1 binds MTMR2
Q9Y217	MTMR6	MTMR6 binds MTMR9
P42285	MTREX	Formation of the Spliceosomal B complex
P42285	MTREX	Formation of the Spliceosomal B* complex
P42285	MTREX	Formation of the Spliceosomal Bact complex
P42285	MTREX	Formation of the Spliceosomal C complex containing intron lariat
P42285	MTREX	Formation of the Spliceosomal C* complex
P42285	MTREX	Formation of the Spliceosomal P complex and exon ligation
P42285	MTREX	Formation of the Spliceosomal Pre-B complex
P42285	MTREX	MPHOSPH8 of the HUSH complex bound to retroelement chromatin binds ZCCHC8 of the NEXT complex
P42285	MTREX	RNA exosome in PAXT:PAPOLG:TENT4A,B:ZC3H3:CBCA:polyadenylated m7GpppN-RNA:PABPN1 hydrolyzes RNA
P42285	MTREX	The PAXT connection (ZFC3H1:MTREX, ZFC3H1:MTR4), RBM26, RBM27, PAPOLG, YTHDC1, and YTHDC2 bind CBCA:polyadenylated m7GpppN-RNA:PABPN1
Q13564	NAE1	NEDD8 covalently binds catalytic cysteine of UBA3:NAE1
Q13564	NAE1	NEDD8-UBA3:NAE1 binds a second NEDD8
Q13564	NAE1	Transfer of NEDD8 to AcM-UBE2F
Q13564	NAE1	Transfer of NEDD8 to AcM-UBE2M
O15239	NDUFA1	Intermediate 1 binds HP subcomplex to form Intermediate 2
Q86Y39	NDUFA11	Intermediate 1 binds HP subcomplex to form Intermediate 2
Q9UI09	NDUFA12	NDUF subunits bind to form the FP subcomplex
Q9UI09	NDUFA12	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex
Q9P0J0	NDUFA13	HTRA2 binds NDUFA13 (GRIM-19)
Q9P0J0	NDUFA13	HTRA2 degrades NDUFA13 (GRIM-19)
Q9P0J0	NDUFA13	Intermediate 1 binds HP subcomplex to form Intermediate 2
O43678	NDUFA2	Intermediate 1 binds HP subcomplex to form Intermediate 2
O95167	NDUFA3	Intermediate 1 binds HP subcomplex to form Intermediate 2
Q16718	NDUFA5	Intermediate 1 binds HP subcomplex to form Intermediate 2
P56556	NDUFA6	Intermediate 1 binds HP subcomplex to form Intermediate 2
O95182	NDUFA7	Intermediate 1 binds HP subcomplex to form Intermediate 2
P51970	NDUFA8	Intermediate 1 binds HP subcomplex to form Intermediate 2
Q16795	NDUFA9	NDUF subunits bind to form the IP subcomplex
O14561	NDUFAB1	Intermediate 1 binds HP subcomplex to form Intermediate 2
O14561	NDUFAB1	LIPT2 transfers octanoyl group to GCSH
O14561	NDUFAB1	MCAT transfers Mal from Mal-CoA to NDUFAB1
O14561	NDUFAB1	MTRFR:MTRES1:39S ribosomal subunit:mRNA:peptidyl-tRNA:MALSU1:MIEF1:NDUFAB1 dissociates
O14561	NDUFAB1	Stalled 55S mitochondrial ribosome is dissociated to yield 28S subunit and 39S subunit:mRNA:peptidyl-tRNA:tRNA
O75438	NDUFB1	Intermediate 1 binds HP subcomplex to form Intermediate 2
O96000	NDUFB10	Intermediate 1 binds HP subcomplex to form Intermediate 2
Q9NX14	NDUFB11	Intermediate 1 binds HP subcomplex to form Intermediate 2
O95178	NDUFB2	Intermediate 1 binds HP subcomplex to form Intermediate 2
O43676	NDUFB3	Intermediate 1 binds HP subcomplex to form Intermediate 2
O95168	NDUFB4	Intermediate 1 binds HP subcomplex to form Intermediate 2
O43674	NDUFB5	Intermediate 1 binds HP subcomplex to form Intermediate 2
O95139	NDUFB6	COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex
O95139	NDUFB6	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex
P17568	NDUFB7	Intermediate 1 binds HP subcomplex to form Intermediate 2
O95169	NDUFB8	Intermediate 1 binds HP subcomplex to form Intermediate 2
Q9Y6M9	NDUFB9	Intermediate 1 binds HP subcomplex to form Intermediate 2
O43677	NDUFC1	Intermediate 1 binds HP subcomplex to form Intermediate 2
O95298	NDUFC2	Intermediate 1 binds HP subcomplex to form Intermediate 2
P28331	NDUFS1	NDUF subunits bind to form the FP subcomplex
O75489	NDUFS3	IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1
O75489	NDUFS3	NDUF subunits bind to form the IP subcomplex
O43181	NDUFS4	NDUF subunits bind to form the FP subcomplex
O43181	NDUFS4	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex
O43920	NDUFS5	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex
O43920	NDUFS5	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I
O75380	NDUFS6	NDUF subunits bind to form the FP subcomplex
O75380	NDUFS6	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex
O75251	NDUFS7	NDUF subunits bind to form the IP subcomplex
O00217	NDUFS8	NDUF subunits bind to form the IP subcomplex
P49821	NDUFV1	NDUF subunits bind to form the FP subcomplex
P49821	NDUFV1	NUBPL transfers 4Fe-4S to NDUFV1, V2
P19404	NDUFV2	NDUF subunits bind to form the FP subcomplex
P19404	NDUFV2	NUBPL transfers 4Fe-4S to NDUFV1, V2
P56181	NDUFV3	NDUF subunits bind to form the FP subcomplex
P56181	NDUFV3	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex
Q9Y5B8	NME7	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
P29475	NOS1	ATP2B4 binds to NOS1, inhibiting it	nNOS
P35228	NOS2	NOS2 gene produces NOS2 protein	iNOS
P29474	NOS3	depalmitoylated eNOS translocates from plasma membrane
P29474	NOS3	Depalmitoylation of eNOS
P29474	NOS3	eNOS associates with Caveolin-1
P29474	NOS3	eNOS binds NOSIP
P29474	NOS3	eNOS translocation from Golgi to Caveolae
P29474	NOS3	N-myristoylation of eNOS
P29474	NOS3	Palmitoylation of eNOS
P16066	NPR1	NPPA(124-151) binds NPR1
P20594	NPR2	NPR2 binds NPPC
P11926	ODC1	Antizyme OAZ binds to Ornithine decarboxylase
P11926	ODC1	NQO1 interaction with ODC
P11926	ODC1	ODC dimerizes
P00480	OTC	OTC precursor is targeted to the mitochondrial matrix and processed
P11498	PC	HLCS biotinylates PC:Mn2+
Q14432	PDE3A	PDE3A inhibitors bind PDE3A
P27815	PDE4A	PDE4A binds PDE4A inhibitors
Q08499	PDE4D	p-S715-PDE4D5 binds p-S26-ANXA2:integrin alpha5:integrin beta1:fibronectin (p-S26-ANXA2:ITGA5:ITGB1:fibronectin)
O76074	PDE5A	PDE5A dimer binds PDE5A inhibitors
P00558	PGK1	EsxA binds PGK1
O14832	PHYH	TYSND1 cleaves PHYH
Q9UBF8	PI4KB	PI4KB binds to ARF1/3:GTP at the Golgi membrane
O00443	PIK3C2A	Clathrin recruits PIK3C2A
O00443	PIK3C2A	F- and N- BAR domain proteins bind the clathrin-coated pit
Q8NEB9	PIK3C3	AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex
Q8NEB9	PIK3C3	Beclin-1 complex translocates to the ER
Q8NEB9	PIK3C3	BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2
Q8NEB9	PIK3C3	NS1 binds Beclin-1
Q8NEB9	PIK3C3	Rab5-mediated recruitment of class III PI3K to TLR9
Q8NEB9	PIK3C3	SARS-CoV-2 8:class I MHC binds BECN1
Q8NEB9	PIK3C3	The phagophore extends from the PIP3-enriched structure
P42336	PIK3CA	Activated cytosolic FGFR1 fusions bind PIK3CA
P42336	PIK3CA	Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
P42336	PIK3CA	Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
P42336	PIK3CA	Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
P42336	PIK3CA	Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
P42336	PIK3CA	Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
P42336	PIK3CA	Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
P42336	PIK3CA	Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
P42336	PIK3CA	Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
P42336	PIK3CA	Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
P42336	PIK3CA	Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
P42336	PIK3CA	Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
P42336	PIK3CA	Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
P42336	PIK3CA	Activated NTRK2 recruits PI3K
P42336	PIK3CA	Activated NTRK3 binds PI3K
P42336	PIK3CA	Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
P42336	PIK3CA	Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
P42336	PIK3CA	ALK mutants bind PI3KCA
P42336	PIK3CA	BCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA
P42336	PIK3CA	Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
P42336	PIK3CA	Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants
P42336	PIK3CA	Binding of PI3K to complex of GRB2:GAB1 and p-EGFRvIII
P42336	PIK3CA	Binding of PI3K to ERBB2:p-ERBB3 heterodimer
P42336	PIK3CA	Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
P42336	PIK3CA	Direct recruitment of PI3K to p-KIT
P42336	PIK3CA	FLT3 fusions recruit PIK3CA through PIK3R1
P42336	PIK3CA	FLT3 mutants recruit PIK3CA through PIK3R1
P42336	PIK3CA	G alpha (q) inhibits PI3K alpha
P42336	PIK3CA	Indirect recruitment of PI3K to KIT via p(Y)-GAB2
P42336	PIK3CA	PI3K binds membrane-associated estrogen receptors
P42336	PIK3CA	PI3K binds to EGF:EGFR:GRB2:GAB1	Inositol phosphate
P42336	PIK3CA	RAC1,RAC2,RHOG activate PI3K
P42338	PIK3CB	GPVI stimulates PI3K beta, gamma
P48736	PIK3CG	Gbeta:gamma recruits PI3K gamma
P48736	PIK3CG	GPVI stimulates PI3K beta, gamma
O60331	PIP5K1C	CDH1 binds to PIP5K1C
O60331	PIP5K1C	Inhibition of integrin activation by sequestering PIP5KIgamma
P30613	PKLR	HNF1A-dependent synthesis of the L isoform of PKLR protein
P30613	PKLR	SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to PKL
P30613	PKLR	Transcriptional activation of PKLR gene by ChREBP:MLX
P14618	PKM	CTLH E3 ligase ubiquitinates PKM-1
P14618	PKM	PKM and TGIF2 bind CDH1 gene promoter
P14555	PLA2G2A	PLA2G2A binds bacterial phospholipids
P47712	PLA2G4A	Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase
Q00722	PLCB2	GNB1,3:GNG13 binds PLCB2:Ca2+
P19174	PLCG1	2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1
P19174	PLCG1	Activated FGFR1 binds PLCG1
P19174	PLCG1	Activated FGFR1 mutants and fusions bind PLCG1
P19174	PLCG1	Activated FGFR2 binds PLCG1
P19174	PLCG1	Activated FGFR2 mutants bind PLCG1
P19174	PLCG1	Activated FGFR3 binds PLCG1
P19174	PLCG1	Activated FGFR3 point and translocation mutants bind PLCG1
P19174	PLCG1	Activated FGFR4 binds PLCG1
P19174	PLCG1	Activated FGFR4 mutants bind PLCG1
P19174	PLCG1	Activated NTRK3 binds PLCG1
P19174	PLCG1	Activated PCLG1 dissociates from NTRK2
P19174	PLCG1	Activated PCLG1 dissociates from NTRK3
P19174	PLCG1	Activated PLC gamma dissociates from the PDGF receptor
P19174	PLCG1	Active ALK binds PLCG1
P19174	PLCG1	Active PLC-gamma1 dissociates from EGFR
P19174	PLCG1	Active PLCG1 dissociates from TrkA receptor
P19174	PLCG1	ALK fusion proteins bind PLCG1
P19174	PLCG1	Binding of PLCG1 to active TrkA receptor
P19174	PLCG1	Disassociation of PLC-gamma1 from LAT
P19174	PLCG1	Disassociation of PLC-gamma1 from SLP-76
P19174	PLCG1	Interaction of PECAM-1 and PLC gamma1
P19174	PLCG1	p-4Y- PLCG1 dissociates from activated FGFR1 mutants and fusions
P19174	PLCG1	p-4Y-PLCG1 dissociates from activated FGFR1
P19174	PLCG1	p-4Y-PLCG1 dissociates from activated FGFR2
P19174	PLCG1	p-4Y-PLCG1 dissociates from activated FGFR2 mutants
P19174	PLCG1	p-4Y-PLCG1 dissociates from activated FGFR3
P19174	PLCG1	p-4Y-PLCG1 dissociates from activated FGFR3 point and translocation mutants
P19174	PLCG1	p-4Y-PLCG1 dissociates from activated FGFR4
P19174	PLCG1	p-4Y-PLCG1 dissociates from activated FGFR4 mutants
P19174	PLCG1	p-6Y-VEGFR2 binds PLCG1
P19174	PLCG1	p-Y817 of p-5Y-NTRK2 recruits PLCG1
P19174	PLCG1	Phospholipase C-gamma1 binds to the activated EGF receptor
P19174	PLCG1	PLC-gamma 1 binds to p-EGFRvIII mutant
P19174	PLCG1	PLC-gamma binds to the active receptor
P19174	PLCG1	PLCG1 binds to ligand-responsive p-6Y-EGFR mutants
P19174	PLCG1	PLCG1 binds to p-ERBB2:p-EGFR
P19174	PLCG1	PLCG1 disassociates from VEGFR2 and translocate to PM
P19174	PLCG1	Recruitment of PLC-gamma1 to LAT
P19174	PLCG1	Recruitment of PLC-gamma1 to SLP-76
P19174	PLCG1	Translocation of PLC-gamma1 to PIP2
P16885	PLCG2	p-DAPP1 (p-BAM32) binds PLCG2
P16885	PLCG2	p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane
P16885	PLCG2	PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated
P16885	PLCG2	PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G
P16885	PLCG2	PLCG2 translocates from cytosol to plasma membrane
P16885	PLCG2	SLP-76 stimulates PLC gamma 2
O60568	PLOD3	PLOD3 binds Lysyl hydroxylated collagen propeptides
O60568	PLOD3	PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides dissociates
O60568	PLOD3	PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides dissociates
Q06203	PPAT	Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer
Q06203	PPAT	Formation of phosphoribosyl pyrophosphate amidotransferase tetramer
Q06830	PRDX1	PRDX1 overoxidizes
Q06830	PRDX1	SESN1,2,3 bind overoxidized PRDX1
Q06830	PRDX1	SRXN1 reduces hyperoxidized PRDX1 dimer
P60484	PTEN	Deubiquitinated PTEN translocates to the cytosol
P60484	PTEN	MKRN1 polyubiquitinates PTEN
P60484	PTEN	Monoubiquitinated PTEN translocates to the nucleus
P60484	PTEN	NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
P60484	PTEN	OTUD3 deubiquitinates PTEN
P60484	PTEN	PTEN binds FRK
P60484	PTEN	PTEN mRNA translation is inhibited by miR-137
P60484	PTEN	PTEN mRNA translation is negatively regulated by microRNAs
P60484	PTEN	PTEN mRNA translation negatively regulated by microRNAs
P60484	PTEN	PTEN undergoes monoubiquitination
P60484	PTEN	RNF146 polyubiquitinates PARylated PTEN
P60484	PTEN	TNKS and TNKS2 PARylate PTEN
P60484	PTEN	TRIM27 binds PTEN
P60484	PTEN	TRIM27 polyubiquitinates PTEN
P60484	PTEN	USP7 deubiquitinates monoubiquitinated PTEN
Q15185	PTGES3	AHR:2xHSP90:AIP:PTGES3 binds TCDD
Q15185	PTGES3	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates
Q15185	PTGES3	Androgens binds AR (in the HSP90 chaperone complex)
Q15185	PTGES3	AR binds AR agonists
Q15185	PTGES3	AR binds AR antagonists
Q15185	PTGES3	Dissociation of cytosolic HSF1:HSP90 complex
Q15185	PTGES3	Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates
Q15185	PTGES3	Dissociation of HSF1:HSP90 complex in the nucleus
Q15185	PTGES3	ESR1 binds ESR1 agonists
Q15185	PTGES3	ESR1 binds ESR1 antagonists
Q15185	PTGES3	ESTG binds ESR1:chaperone complex
Q15185	PTGES3	ESTG binds ESR2:chaperone complex
Q15185	PTGES3	FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein
Q15185	PTGES3	HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus
Q15185	PTGES3	HSP90:FKBP4:PTGES3 binds HSF1 trimer
Q15185	PTGES3	NR3C1 binds NR3C1 agonists
Q15185	PTGES3	NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex)
Q15185	PTGES3	NR3C2 binds fludrocortisone
Q15185	PTGES3	NR3C2 binds NR3C2 antagonists
Q15185	PTGES3	NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex)
Q15185	PTGES3	p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein
Q15185	PTGES3	p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein
Q15185	PTGES3	P4 bind PGR (in the HSP90 chaperone complex)
Q15185	PTGES3	PGR binds PGR agonists
Q15185	PTGES3	PGR binds PGR antagonists
Q15185	PTGES3	Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG
P23219	PTGS1	ASA- acetylates PTGS1	Aspirin
P23219	PTGS1	PTGS1 dimer binds PTGS1 Inhibitors
P23219	PTGS1	PTGS1,2 dimers bind PTGS Inhibitors
P35354	PTGS2	ASA- acetylates PTGS2	Aspirin
P35354	PTGS2	PTGS1,2 dimers bind PTGS Inhibitors
P35354	PTGS2	PTGS2 dimer binds PTGS inhibitors
P35354	PTGS2	PTGS2 dimer binds PTGS2 inhibitors
P11216	PYGB	PYGB b dimer:AMP complex => PGYB dimer, b form + 2 AMP
P11216	PYGB	PYGB dimer, b form + 2 AMP => PYGB b dimer:AMP complex
P11217	PYGM	PYGM b dimer:AMP complex => PYGM dimer, b form + 2 AMP
P11217	PYGM	PYGM dimer, b form + 2 AMP => PYGM b dimer:AMP complex
P50914	RPL14	12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA
P50914	RPL14	Dissociation of L13a from the 60s ribosomal subunit
P50914	RPL14	Release of 40S and 60S subunits from the 80S ribosome
P50914	RPL14	The 60S subunit joins the translation initiation complex
P50914	RPL14	VCP hexamer extracts K48 polyubiquitinated alanine-tailed nascent peptide from VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:K48polyUb-nascent peptide
Q7LG56	RRM2B	TP53 stimulates transcription of RRM2B gene
P22307	SCP2	TYSND1 cleaves SCP2
P31040	SDHA	FAD attaches to SDHA
P31040	SDHA	SDHA binds to SDHB
P31040	SDHA	SDHA:SDHB binds to SDHC:SDHD
P31040	SDHA	SDHAF4 binds to FAD-SDHA
P21912	SDHB	SDHA binds to SDHB
P21912	SDHB	Transfer of Fe-S clusters to SDHB
Q99643	SDHC	SDHA:SDHB binds to SDHC:SDHD
O14521	SDHD	SDHA:SDHB binds to SDHC:SDHD
Q15047	SETDB1	ATF7IP binds SETDB1
Q15047	SETDB1	ATF7IP:SETDB1 binds SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin
Q15047	SETDB1	me3-K16-ATF7IP:SETDB1 and MORC2 bind MPHOSPH8 (MPP8) in HUSH complex:L1 RNA
Q15047	SETDB1	me3-K16-ATF7IP:SETDB1 and MORC2 bind MPHOSPH8 (MPP8) in HUSH complex:L1HS,L1PA2,3 heterochromatin
P55017	SLC12A3	SLC12A3 binds SLC12A3 inhibitors
Q8N697	SLC15A4	SLC15A4 binds TASL
Q8N697	SLC15A4	TASL recruits IRF5
Q9P2U7	SLC17A7	Glutamate synaptic vesicle docking and priming
Q9P2U7	SLC17A7	L-Glutamate loading of synaptic vesicle
Q9P2U7	SLC17A7	Release of L-Glutamate at the synapse
Q05940	SLC18A2	Dopamine synaptic vesicle docking and priming
Q05940	SLC18A2	Noradrenalin synaptic vesicle docking and priming
Q05940	SLC18A2	Release of docked dopamine loaded synaptic vesicle
Q05940	SLC18A2	Release of docked serotonin loaded synaptic vesicle
Q05940	SLC18A2	Release of noradrenaline at the synapse
Q05940	SLC18A2	Serotonin loaded synaptic vesicle docking and priming
Q16572	SLC18A3	Acetylcholine synaptic vesicle docking and priming
Q16572	SLC18A3	Loading of acetylcholine in synaptic vesicles
Q16572	SLC18A3	Release of acetylcholine at the synapse
P12235	SLC25A4	ARL2:GTP:ARL2BP binds SLC25A4
P12236	SLC25A6	PB1-F2 binds to the mitochondrial adenine nucleotide translocator 3 ANT3, inducing apoptosis
P11166	SLC2A1	GLUT1 tetramer binds 4xATP
P11166	SLC2A1	GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP
P11168	SLC2A2	HNF1A-dependent synthesis of GLUT2 protein
P14672	SLC2A4	SLC2A4 (GLUT4) vesicle fuses with the plasma membrane
Q9H598	SLC32A1	GABA loaded synaptic vesicle Docking and Priming
Q9H598	SLC32A1	Release of GABA at the synapse
P31639	SLC5A2	SLC5A2 binds gliflozins
Q01959	SLC6A3	SLC6A3 binds DRIs
P31645	SLC6A4	SLC6A4 binds TCAs and SSRIs
P19634	SLC9A1	HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+
P00441	SOD1	SOD1:Zn2+ apoenzyme binds CCS:Cu1+ (mitochondrial)
P00441	SOD1	SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+
P08294	SOD3	ATP7A transfers Cu from ATOX1 to SOD3
Q9NRA0	SPHK2	SPHK2 binds SPHK2 inhibitors
P31213	SRD5A2	SRD5A2 binds SRD5A2 inhibitors
O43463	SUV39H1	Formation of energy-dependent Nucleolar Silencing Complex (eNoSC)
Q9UDW1	UQCR10	Late core complex dimer binds UQCR10, UQCR11, UQCRFS1.
O14957	UQCR11	Late core complex dimer binds UQCR10, UQCR11, UQCRFS1.
P14927	UQCRB	Intermediate I binds second heme, UQCRB, UQCRQ
P14927	UQCRB	Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH
P14927	UQCRB	Late core complex dimerizes
P31930	UQCRC1	Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH
P31930	UQCRC1	Late core complex dimerizes
P22695	UQCRC2	Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH
P22695	UQCRC2	Late core complex dimerizes
P47985	UQCRFS1	2Fe-2S is inserted in UQCRFS1
P47985	UQCRFS1	apo-UQCRFS1 binds LYRM7
P47985	UQCRFS1	Late core complex dimer binds UQCR10, UQCR11, UQCRFS1.
O14949	UQCRQ	Intermediate I binds second heme, UQCRB, UQCRQ
O14949	UQCRQ	Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH
O14949	UQCRQ	Late core complex dimerizes
P47989	XDH	BTN1A1 binds xanthine oxidoreductase (XDH)

Table 1c. Gene expression signalling processes & Recon2 catalysers

UniProt	HGNC	Reactome processes	MRegAtlas
O95477	ABCA1	Expression of ABCA1
P21439	ABCB4	Expression of ABCB4
P33527	ABCC1	NFE2L2 dependent ABCC1 expression
O15438	ABCC3	NFE2L2 dependent ABCC3 expression
O00763	ACACB	Expression of Acetyl CoA Carboxylase 2 (ACACB, ACC2)
P11310	ACADM	Expression of ACADM
P49748	ACADVL	Expression of ACADVL
Q15067	ACOX1	Expression of ACOX1
P33121	ACSL1	ACSL1 gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex
P33121	ACSL1	Expression of ACSL1
Q9H6R3	ACSS3	ACSS3 gene expression is stimulated by PPARG2:RXRA:MLL4(MLL3)-ASCOM complex
O15120	AGPAT2	AGPAT2 gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex
Q9GZX7	AICDA	BATF, CEBPA, HOXC4, RELA:NFKB1, NFKB2:RELB, TCF3:E2F2, PAX5, IRF8, STAT6 positively regulate expression of AICDA
P13196	ALAS1	Expression of ALAS1
P05089	ARG1	ARG1 gene expression
Q13510	ASAH1	MITF-M-dependent ASAH1 expression
P08243	ASNS	Expression of ASNS (Asparagine Synthetase)
P00915	CA1	Expression of Carbonic anhydrase 1
Q16790	CA9	Expression of Carbonic Anhydrase IX (CA9)
P04040	CAT	CAT gene expression is stimulated by FOXO3,FOXO6,(FOXO1)
P04040	CAT	CAT gene expression is stimulated by Foxo6
P04040	CAT	FOXO3 activates expression of CAT
P31327	CPS1	CPS1 gene expression
P50416	CPT1A	Expression of Carnitine O-palmitoyltransferase 1 CPT1A
P23786	CPT2	Expression of CPT2
P04798	CYP1A1	Expression of CYP1A1
Q02928	CYP4A11	Expression of CYP4A11
Q16850	CYP51A1	CYP51A1 gene expression
Q16850	CYP51A1	Expression of Lanosterol Demethylase (CYP51A1)
P22680	CYP7A1	Expression of CYP7A1
P40126	DCT	MITF-M-dependent DCT gene expression
Q96PD7	DGAT2	DGAT2 gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex
Q9UBM7	DHCR7	Expression of 7-Dehydrocholesterol Reductase (DHCR7)
P00374	DHFR	DHFR gene expression is stimulated by E2F1
P00533	EGFR	EGFR gene expression is stimulated by TFAP2C
Q9NYP7	ELOVL5	ELOVL5 gene expression is stimulated by PPARG2:RXRA:MLL4(MLL3)-ASCOM complex
Q9H5J4	ELOVL6	Expression of ELOVL6
Q92935	EXTL1	Expression of EXTL1
Q9UBQ6	EXTL2	Expression of EXTL2
O43909	EXTL3	Expression of EXTL3
P07148	FABP1	Expression of FABP1
O60427	FADS1	Expression of FADS1
P49327	FASN	Expression of FASN regulated by NR1H2 or NR1H3
P49327	FASN	Expression of Fatty Acid Synthase (FASN)
P09467	FBP1	TCF19:NuRD represses FBP1 gene expression
P37268	FDFT1	Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase)
P14324	FDPS	Expression of Farnesyl Diphosphate Synthase (FDPS)
P35575	G6PC1	G6PC gene expression is stimulated by FOXO1,FOXO3,FOXO4,FOXO6
P35575	G6PC1	TCF19:NuRD represses G6PC gene expression
Q99259	GAD1	GAD1 gene expression is stimulated by MECP2
Q05329	GAD2	GAD2 gene expression is stimulated by MECP2
Q14353	GAMT	GAMT gene expression is stimulated by MECP2
P35557	GCK	GCK gene expression is inhibited by FOXO1, SIN3A and HDACs
Q06210	GFPT1	Expression of GFPT1
O95749	GGPS1	Expression of Geranylgeranyl Pyrophosphate Synthase (GGPS1)
P36959	GMPR	MITF-M-dependent GMPR expression
Q9HCL2	GPAM	Expression of Glycerol-3-phosphate Acyltransferase (GPAM, GPAT)
Q9HCL2	GPAM	GPAM gene expression is stimulated by PPARG2:RXRA:MLL4,(MLL3)-ASCOM complex
Q9HCL2	GPAM	GPAM gene expression is stimulated by RUNX1 and ESR1
P00390	GSR	NFE2L2-dependent GSR gene expression
P04035	HMGCR	Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR)
P04035	HMGCR	HMGCR gene expression
Q01581	HMGCS1	Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1)
P54868	HMGCS2	Expression of HMGCS2
P09601	HMOX1	Expression of HMOX1
P09601	HMOX1	NFE2L2-dependent HMOX1 gene expression
O75874	IDH1	NFE2L2-dependent IDH1 gene expression
Q13907	IDI1	Expression of Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)
P06858	LPL	Expression of Lipoprotein lipase (LPL)
P06858	LPL	LPL gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex
P48449	LSS	Expression of Lanosterol Synthase (LSS)
P21397	MAOA	Expression of MAOA
P48163	ME1	Expression of ME1
Q99685	MGLL	MGLL gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex
Q13126	MTAP	Expression of S-methyl-5'-thioadenosine phosphorylase
P53602	MVD	Expression of Diphosphomevalonate Decarboxylase (MVD)
Q03426	MVK	Expression of Mevalonate Kinase (MVK)
P00480	OTC	OTC gene expression
P35558	PCK1	Expression of PCK1 regulated by NR1H3
P35558	PCK1	Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C)
P35558	PCK1	PCK1 gene expression is stimulated by FOXO1:PPARGC1A
P35558	PCK1	TCF19:NuRD represses PCK1 gene expression
P52209	PGD	NFE2L2-dependent PGD gene expression
Q15126	PMVK	Expression of Phosphomevalonate Kinase (PMVK)
Q06830	PRDX1	NFE2L2-dependent PRDX1 gene expression
P41222	PTGDS	Expression of PTGDS in testis differentiation
P35354	PTGS2	Expression of PTGS2
P31350	RRM2	RRM2 gene expression is stimulated by E2F1 and inhibited by E2F6
O75845	SC5D	Expression of Lathosterol Oxidase (SC5D, SC5DL)
O00767	SCD	Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD)
O00767	SCD	Expression of SCD regulated by NR1H2 or NR1H3
O00767	SCD	SCD gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex
Q86SK9	SCD5	SCD5 gene expression
Q6PCB7	SLC27A1	Expression of FATP1 (SLC27A1)
P11169	SLC2A3	SLC2A3 gene expression is stimulated by MECP2:CREB1 complex
P14672	SLC2A4	Expression of GLUT4
P00441	SOD1	Expression of SOD1
P04179	SOD2	Expression of superoxide dismutase 2
P04179	SOD2	FOXO3 activates expression of SOD2
P04179	SOD2	SOD2 (MnSOD) gene expression
P04179	SOD2	SOD2 gene expression is stimulated by FOXO4, FOXO3 and FOXO1
P08294	SOD3	NFE2L2 dependent SOD3 expression
P0DMM9	SULT1A3	Expression of SULT1A3
Q06520	SULT2A1	Expression of SULT2A1
P37837	TALDO1	Expression of transaldolase 1
P37837	TALDO1	NFE2L2-dependent TALDO1 gene expression
P04183	TK1	TK1 gene expression is stimulated by E2F1
P29401	TKT	NFE2L2-dependent TKT gene expression
O76062	TM7SF2	Expression of TM7SF2
P17752	TPH1	TPH1 gene expression
O14773	TPP1	Expression of TPP1
Q16881	TXNRD1	AcK-NFE2L2-dependent TXNRD1 gene expression
Q16881	TXNRD1	Expression of TXNRD1
P04818	TYMS	TYMS gene expression
P14679	TYR	MITF-M-dependent TYR gene expression
P17643	TYRP1	MITF-M-dependent TYRP1 gene expression
P25874	UCP1	UCP1 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD
P35503	UGT1A3	Expression of UGT1A3
O60656	UGT1A9	Expression of UGT1A9