Reactome-Recon List 1

These tables contain proteins from the Human Metabolic Reconstruction Recon2 that match those in Reactome pathways and participate in signalling processes, the cases when a protein connected to a process via production or consumption arcs. Table 1a includes phosphorylation processes, while Tables 1b and 1c include other types of processes.

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Table 1a. Signalling phosphorylation processes & Recon2 catalysers

UniProtHGNCReactome processesMRegAtlas
Q9NYG5ANAPC11Phosphorylation of Cdh1 by Cyclin A:Cdk2
P32119PRDX2CDK5:p25 phosphorylates PRDX2
P06737PYGLglycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADPGlycogen
P09917ALOX5ALOX5 is phosphorylated by MAPKAP2
P29474NOS3AKT1 phosphorylates eNOSeNOS
P11217PYGMglycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADPGlycogen
P19174PLCG1Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants
Q06830PRDX1CDK5:p25 phosphorylates PRDX1
P11216PYGBglycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP
P15328FOLR1CSNK1D phosphorylates SEC23
Q03393PTSPTPS is phosphorylated by cGMP-dependant protein kinase II
P16885PLCG2Phosphorylation and activation of PLCG
P14672SLC2A4GLUT4 vesicle fuses with the plasma membrane
P35270SPRSepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase IIeNOS
Q9NY65TUBA8Phosphorylation of cohesin by PLK1 at centromeres
P00533EGFRPhosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutantsInositol phosphate
Q16555DPYSL2Phosphorylation of CRMPs by Cdk5
P09622DLDBCKDK phosphorylates BCKDH
P47712PLA2G4APhosphorylation of cPLA2 by ERK-2Eicosanoids

Table 1b. Other signalling processes & Recon2 catalysers

UniProtHGNCReactome processesMRegAtlas
P11926ODC1Antizyme OAZ binds to Ornithine decarboxylase
Q5FWF5ESCO1Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2
P08559PDHA1PDK-catalyzed phosphorylation (inactivation) of PDC E1 alpha subunit
P06737PYGLpoly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL]Glycogen
P06858LPLchylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols
P19174PLCG1PLCG1 binds to ligand-responsive p-6Y-EGFR mutants
Q5VV43KIAA0319F- and N- BAR domain proteins bind the clathrin-coated pit
P15328FOLR1Vesicle budding
P25092GUCY2CGUCY2C trimer binds GUCA2A,B
Q9Y4K0LOXL2Elastin cross-linking by lysyl oxidase
Q9Y6K1DNMT3APRC2 recruits DNA methyltransferases
P30048PRDX3PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O
Q05329GAD2Release of GABA at the synapse
Q96RQ3MCCC1HLCS biotinylates MCCC1:MCCC2
P16066NPR1NPPA(124-151) binds NPR1
P20594NPR2NPR2 binds NPPC
P15291B4GALT1Association of ADAM and B4GALT1 With ZP3
Q16795NDUFA9Intermediate 1 binds HP subcomplex to form Intermediate 2
Q16555DPYSL2Interaction of NUMB with L1
P47712PLA2G4APhospho-cPLA2 translocates to membranes when intracellular calcium levels increaseEicosanoids
P06865HEXAHexosaminidase A cleaves GalNAc from GM2 to form GM3
P32019INPP5BGAPs inactivate Rho GTPase:GTP by hydrolysisInositol phosphate
Q8TC12RDH11RDH10,11 oxidise 11cROL to 11cRAL
P11217PYGMpoly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]Glycogen
O75610LEFTY1LEFTY binds NODAL
Q9UBC3DNMT3BPRC2 recruits DNA methyltransferases
O75452RDH16RDH5 oxidises 11cROL to 11cRAL
P11216PYGBPGYB b dimer:AMP complex <=> PGYB dimer, b form + 2 AMP
Q9NQR1KMT5ASETD8 monomethylates histone H4
P17516AKR1C4AKRs reduce RBP2:atRAL to RBP2:atROL
P11498PCHLCS biotinylates PC:Mn2+
O75251NDUFS7NUBPL transfers 4Fe-4S to Complex I subunits
Q9BYF1ACE2ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)
Q08828ADCY1G alpha (s) activates adenylate cyclaseGlycolysis
Glycogen
Estradiol
O60331PIP5K1CInhibition of integrin activation by sequestering PIP5KIgamma
Q9NY59SMPD3TNF-alpha:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3
P08574CYC1Electron transfer from ubiquinol to cytochrome c of complex III
P47985UQCRFS1Electron transfer from ubiquinol to cytochrome c of complex III
P00533EGFRF- and N- BAR domain proteins bind the clathrin-coated pitInositol phosphate
P07686HEXBHexosaminidase A cleaves GalNAc from GM2 to form GM3
P47989XDHBTN1A1 binds xanthine oxidoreductase (XDH)
P09622DLDPDK-catalyzed phosphorylation (inactivation) of PDC E1 alpha subunit
Q92835INPP5DInteraction of PECAM-1 and SHIPInositol phosphate
P29474NOS3The cofactor BH4 is required for electron transfer in the eNOS catalytic cycleeNOS
P31350RRM2RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)
P35354PTGS2PTGS2 dimer binds celecoxibEicosanoids
Aspirin
O00443PIK3C2Atrans-Golgi Network Coat Assembly
O95299NDUFA10Intermediate 1 binds HP subcomplex to form Intermediate 2
P19634SLC9A1HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+
Q9NY65TUBA8ERGIC-to-Golgi vesicles bind dynein:dynactin
P04180LCATLCAT + discoidal HDL <=> LCAT:discoidal HDL complex
Q96KQ7EHMT2Cdh1:APC/C ubiquitinates EHMT1 and EHMT2
O60266ADCY3G alpha (s) activates adenylate cyclaseGlycolysis
Glycogen
Estradiol
P31040SDHATransfer of electrons through the succinate dehydrogenase complex
P00441SOD1CCS transfers Cu to SOD1
P26358DNMT1PRC2 recruits DNA methyltransferases
O43463SUV39H1eNoSC deacetylates histone H3
O95622ADCY5G alpha (s) activates adenylate cyclaseGlycolysis
Glycogen
Estradiol
Q9NYG5ANAPC11Cdh1:APC/C ubiquitinates EHMT1 and EHMT2
P32119PRDX2PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O
P51970NDUFA8Intermediate 1 binds HP subcomplex to form Intermediate 2
P78356PIP4K2BPIN1 binds phosphorylated PIP4K2B
O43306ADCY6G alpha (s) activates adenylate cyclaseGlycolysis
Glycogen
Estradiol
Q06830PRDX1PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O
O43865AHCYL1AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it
P16885PLCG2Recruitment of PLCgamma to membrane
P15289ARSAActive ARSA translocates to the lysosome
P08195SLC3A2Basigin binds CD98 complex
P25874UCP1FA anion flip-flops to the opposite surface

Table 1c. Expression signalling processes & Recon2 catalysers

UniProtHGNCReactome processesMRegAtlas
O95477ABCA1Expression of ABCA1
Q16790CA9Expression of Carbonic Anhydrase IX (CA9)
Q9H5J4ELOVL6Expression of ELOVL6
P54868HMGCS2Expression of HMGCS2Mevalonate
P04179SOD2SOD2 (MnSOD) gene expression
Q16881TXNRD1Expression of TXNRD1
Q06520SULT2A1Expression of SULT2A1
O00763ACACBExpression of Acetyl CoA Carboxylase 2 (ACACB, ACC2)Acyl-carnitine
P35558PCK1Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C)
P11310ACADMExpression of ACADM
P14672SLC2A4Expression of GLUT4
P21439ABCB4Expression of ABCB4
O14773TPP1Expression of TPP1
P0DMM9SULT1A3Expression of SULT1A3
P49748ACADVLExpression of ACADVL